Immune-featured decidual stromal cells: pregnancy's multitasking superstars
Trends Immunol. 2023 Oct 13:S1471-4906(23)00205-3. doi: 10.1016/j.it.2023.09.009. Online ahead of print.ABSTRACTPregnancy poses an immunological challenge, since the mother's immune system must adapt to tolerate the developing embryo until birth. The mechanisms governing this maternal-fetal dialogue have traditionally centered on the immune system. Yang et al. propose a new concept: immune-featured decidual stromal cells (DSCs), which emerge as pivotal players in mammalian maternal-fetal crosstalk.PMID:37867112 | DOI:10.1016/j.it.2023.09.009 (Source: Trends in Immunology)
Source: Trends in Immunology - October 22, 2023 Category: Allergy & Immunology Authors: Nardhy Gomez-Lopez Source Type: research
Towards decoding the space-time continuum of pregnancy
Trends Immunol. 2023 Oct 12:S1471-4906(23)00207-7. doi: 10.1016/j.it.2023.09.011. Online ahead of print.ABSTRACTPregnancy is likely nature's most elaborate model of dynamic adaptations occurring over a distinct period of time at specific sites of the maternal body. Spatially-resolved transcriptomic analyses now enable the comprehensive decoding of these dynamic adaptations during the early onset stages of mammalian pregnancies and throughout fetal development.PMID:37867113 | DOI:10.1016/j.it.2023.09.011 (Source: Trends in Immunology)
Source: Trends in Immunology - October 22, 2023 Category: Allergy & Immunology Authors: Kristin Thiele Petra Clara Arck Source Type: research
Immune-featured decidual stromal cells: pregnancy's multitasking superstars
Trends Immunol. 2023 Oct 13:S1471-4906(23)00205-3. doi: 10.1016/j.it.2023.09.009. Online ahead of print.ABSTRACTPregnancy poses an immunological challenge, since the mother's immune system must adapt to tolerate the developing embryo until birth. The mechanisms governing this maternal-fetal dialogue have traditionally centered on the immune system. Yang et al. propose a new concept: immune-featured decidual stromal cells (DSCs), which emerge as pivotal players in mammalian maternal-fetal crosstalk.PMID:37867112 | DOI:10.1016/j.it.2023.09.009 (Source: Trends in Immunology)
Source: Trends in Immunology - October 22, 2023 Category: Allergy & Immunology Authors: Nardhy Gomez-Lopez Source Type: research
Towards decoding the space-time continuum of pregnancy
Trends Immunol. 2023 Oct 12:S1471-4906(23)00207-7. doi: 10.1016/j.it.2023.09.011. Online ahead of print.ABSTRACTPregnancy is likely nature's most elaborate model of dynamic adaptations occurring over a distinct period of time at specific sites of the maternal body. Spatially-resolved transcriptomic analyses now enable the comprehensive decoding of these dynamic adaptations during the early onset stages of mammalian pregnancies and throughout fetal development.PMID:37867113 | DOI:10.1016/j.it.2023.09.011 (Source: Trends in Immunology)
Source: Trends in Immunology - October 22, 2023 Category: Allergy & Immunology Authors: Kristin Thiele Petra Clara Arck Source Type: research
Mind the GAP: RASA2 and RASA3 GTPase-activating proteins as gatekeepers of T cell activation and adhesion
Trends Immunol. 2023 Oct 17:S1471-4906(23)00194-1. doi: 10.1016/j.it.2023.09.002. Online ahead of print.ABSTRACTFollowing stimulation, the T cell receptor (TCR) and its coreceptors integrate multiple intracellular signals to initiate T cell proliferation, migration, gene expression, and metabolism. Among these signaling molecules are the small GTPases RAS and RAP1, which induce MAPK pathways and cellular adhesion to activate downstream effector functions. Although many studies have helped to elucidate the signaling intermediates that mediate T cell activation, the molecules and pathways that keep naive T cells in check are...
Source: Trends in Immunology - October 20, 2023 Category: Allergy & Immunology Authors: Kristoffer H Johansen Dominic P Golec Klaus Okkenhaug Pamela L Schwartzberg Source Type: research
Mind the GAP: RASA2 and RASA3 GTPase-activating proteins as gatekeepers of T cell activation and adhesion
Trends Immunol. 2023 Oct 17:S1471-4906(23)00194-1. doi: 10.1016/j.it.2023.09.002. Online ahead of print.ABSTRACTFollowing stimulation, the T cell receptor (TCR) and its coreceptors integrate multiple intracellular signals to initiate T cell proliferation, migration, gene expression, and metabolism. Among these signaling molecules are the small GTPases RAS and RAP1, which induce MAPK pathways and cellular adhesion to activate downstream effector functions. Although many studies have helped to elucidate the signaling intermediates that mediate T cell activation, the molecules and pathways that keep naive T cells in check are...
Source: Trends in Immunology - October 20, 2023 Category: Allergy & Immunology Authors: Kristoffer H Johansen Dominic P Golec Klaus Okkenhaug Pamela L Schwartzberg Source Type: research
Mind the GAP: RASA2 and RASA3 GTPase-activating proteins as gatekeepers of T cell activation and adhesion
Trends Immunol. 2023 Oct 17:S1471-4906(23)00194-1. doi: 10.1016/j.it.2023.09.002. Online ahead of print.ABSTRACTFollowing stimulation, the T cell receptor (TCR) and its coreceptors integrate multiple intracellular signals to initiate T cell proliferation, migration, gene expression, and metabolism. Among these signaling molecules are the small GTPases RAS and RAP1, which induce MAPK pathways and cellular adhesion to activate downstream effector functions. Although many studies have helped to elucidate the signaling intermediates that mediate T cell activation, the molecules and pathways that keep naive T cells in check are...
Source: Trends in Immunology - October 20, 2023 Category: Allergy & Immunology Authors: Kristoffer H Johansen Dominic P Golec Klaus Okkenhaug Pamela L Schwartzberg Source Type: research
On developmental programming of the immune system
Trends Immunol. 2023 Oct 16:S1471-4906(23)00196-5. doi: 10.1016/j.it.2023.09.004. Online ahead of print.ABSTRACTEarly-life environmental exposures play a significant role in shaping long-lasting immune phenotypes and disease susceptibility. Nevertheless, comprehensive understanding of the developmental programming of immunity is limited. We propose that the vertebrate immune system contains durable programmable components established through early environmental interactions and maintained in a stable and homeostatic manner. Some immune components, such as immunological memory, are intrinsically programmable. Others are inf...
Source: Trends in Immunology - October 18, 2023 Category: Allergy & Immunology Authors: Jun Young Hong Ruslan Medzhitov Source Type: research
On developmental programming of the immune system
Trends Immunol. 2023 Oct 16:S1471-4906(23)00196-5. doi: 10.1016/j.it.2023.09.004. Online ahead of print.ABSTRACTEarly-life environmental exposures play a significant role in shaping long-lasting immune phenotypes and disease susceptibility. Nevertheless, comprehensive understanding of the developmental programming of immunity is limited. We propose that the vertebrate immune system contains durable programmable components established through early environmental interactions and maintained in a stable and homeostatic manner. Some immune components, such as immunological memory, are intrinsically programmable. Others are inf...
Source: Trends in Immunology - October 18, 2023 Category: Allergy & Immunology Authors: Jun Young Hong Ruslan Medzhitov Source Type: research
Human macrophages choreograph tissue development
Trends Immunol. 2023 Oct 11:S1471-4906(23)00206-5. doi: 10.1016/j.it.2023.09.010. Online ahead of print.ABSTRACTYolk sac-derived macrophages have been described to promote organogenesis and tissue function in animal models, but the relevance of these studies for humans has been debated. Wang et al. reveal that human macrophage development follows similar developmental trajectories with functionally distinct macrophage populations across tissues as observed in mice.PMID:37833121 | DOI:10.1016/j.it.2023.09.010 (Source: Trends in Immunology)
Source: Trends in Immunology - October 13, 2023 Category: Allergy & Immunology Authors: Elvira Mass Source Type: research
Human macrophages choreograph tissue development
Trends Immunol. 2023 Oct 11:S1471-4906(23)00206-5. doi: 10.1016/j.it.2023.09.010. Online ahead of print.ABSTRACTYolk sac-derived macrophages have been described to promote organogenesis and tissue function in animal models, but the relevance of these studies for humans has been debated. Wang et al. reveal that human macrophage development follows similar developmental trajectories with functionally distinct macrophage populations across tissues as observed in mice.PMID:37833121 | DOI:10.1016/j.it.2023.09.010 (Source: Trends in Immunology)
Source: Trends in Immunology - October 13, 2023 Category: Allergy & Immunology Authors: Elvira Mass Source Type: research
Human macrophages choreograph tissue development
Trends Immunol. 2023 Oct 11:S1471-4906(23)00206-5. doi: 10.1016/j.it.2023.09.010. Online ahead of print.ABSTRACTYolk sac-derived macrophages have been described to promote organogenesis and tissue function in animal models, but the relevance of these studies for humans has been debated. Wang et al. reveal that human macrophage development follows similar developmental trajectories with functionally distinct macrophage populations across tissues as observed in mice.PMID:37833121 | DOI:10.1016/j.it.2023.09.010 (Source: Trends in Immunology)
Source: Trends in Immunology - October 13, 2023 Category: Allergy & Immunology Authors: Elvira Mass Source Type: research
Human macrophages choreograph tissue development
Trends Immunol. 2023 Oct 11:S1471-4906(23)00206-5. doi: 10.1016/j.it.2023.09.010. Online ahead of print.ABSTRACTYolk sac-derived macrophages have been described to promote organogenesis and tissue function in animal models, but the relevance of these studies for humans has been debated. Wang et al. reveal that human macrophage development follows similar developmental trajectories with functionally distinct macrophage populations across tissues as observed in mice.PMID:37833121 | DOI:10.1016/j.it.2023.09.010 (Source: Trends in Immunology)
Source: Trends in Immunology - October 13, 2023 Category: Allergy & Immunology Authors: Elvira Mass Source Type: research
IL-2-driven CD8 < sup > + < /sup > T cell phenotypes: implications for immunotherapy
Trends Immunol. 2023 Oct 10:S1471-4906(23)00195-3. doi: 10.1016/j.it.2023.09.003. Online ahead of print.ABSTRACTThe therapeutic potential of interleukin (IL)-2 in cancer treatment has been known for decades, yet its widespread adoption in clinical practice remains limited. Recently, chimeric proteins of an anti-PD-1 antibody and suboptimal IL-2 variants were shown to stimulate potent antitumor and antiviral immunity by inducing unique effector CD8+ T cells in mice. A similar subset of cytotoxic T cells is induced by depletion of regulatory T cells (Tregs), suggesting IL-2 sequestration as a major mechanism through which re...
Source: Trends in Immunology - October 12, 2023 Category: Allergy & Immunology Authors: Veronika Niederlova Oksana Tsyklauri Marek Kovar Ondrej Stepanek Source Type: research
IL-2-driven CD8 < sup > + < /sup > T cell phenotypes: implications for immunotherapy
Trends Immunol. 2023 Oct 10:S1471-4906(23)00195-3. doi: 10.1016/j.it.2023.09.003. Online ahead of print.ABSTRACTThe therapeutic potential of interleukin (IL)-2 in cancer treatment has been known for decades, yet its widespread adoption in clinical practice remains limited. Recently, chimeric proteins of an anti-PD-1 antibody and suboptimal IL-2 variants were shown to stimulate potent antitumor and antiviral immunity by inducing unique effector CD8+ T cells in mice. A similar subset of cytotoxic T cells is induced by depletion of regulatory T cells (Tregs), suggesting IL-2 sequestration as a major mechanism through which re...
Source: Trends in Immunology - October 12, 2023 Category: Allergy & Immunology Authors: Veronika Niederlova Oksana Tsyklauri Marek Kovar Ondrej Stepanek Source Type: research
