Over but not gone: lingering epigenetic effects of COVID-19
Trends Immunol. 2023 Sep 11:S1471-4906(23)00180-1. doi: 10.1016/j.it.2023.08.012. Online ahead of print.ABSTRACT'Long COVID' affects nearly one in five adults who have had coronavirus disease 2019 (COVID-19), yet the mechanisms underlying this disorder remain poorly understood. In a new study, Cheong et al. show that the epigenetic and transcriptional state of myeloid immune cells and their progenitors are durably altered in patients following severe COVID-19.PMID:37704548 | DOI:10.1016/j.it.2023.08.012 (Source: Trends in Immunology)
Source: Trends in Immunology - September 13, 2023 Category: Allergy & Immunology Authors: Brandon T Tran Ruoqiong Cao Katherine Y King Source Type: research
Klebsiella pneumoniae: adaptive immune landscapes and vaccine horizons
Trends Immunol. 2023 Sep 11:S1471-4906(23)00159-X. doi: 10.1016/j.it.2023.08.005. Online ahead of print.ABSTRACTKlebsiella pneumoniae is among the most common antibiotic-resistant pathogens causing nosocomial infections. Additionally, it is a leading cause of neonatal sepsis and childhood mortality across the globe. Despite its clinical importance, we are only beginning to understand how the mammalian adaptive immune system responds to this pathogen. Further, many studies investigating potential K. pneumoniae vaccine candidates or alternative therapies have been launched in recent years. Here, we review the current state o...
Source: Trends in Immunology - September 13, 2023 Category: Allergy & Immunology Authors: Paeton L Wantuch David A Rosen Source Type: research
HLA alleles: important pieces to the COVID-19 puzzle
Trends Immunol. 2023 Sep 9:S1471-4906(23)00179-5. doi: 10.1016/j.it.2023.08.011. Online ahead of print.ABSTRACTResearch on human leukocyte antigen (HLA) molecules in coronavirus disease 2019 (COVID-19) raised high expectations but has yielded limited results. Augusto et al.'s recent study in Nature unveils a strong association of HLA-B*15:01 with asymptomatic COVID-19, representing an important contribution to genetics in COVID-19.PMID:37690961 | DOI:10.1016/j.it.2023.08.011 (Source: Trends in Immunology)
Source: Trends in Immunology - September 10, 2023 Category: Allergy & Immunology Authors: Patricia Castro-Santos Ángel Carracedo Roberto D íaz-Peña Source Type: research
Systems immunology of regulatory T cells: can one circuit explain it all?
Trends Immunol. 2023 Sep 8:S1471-4906(23)00161-8. doi: 10.1016/j.it.2023.08.007. Online ahead of print.ABSTRACTRegulatory T (Treg) cells play vital roles in immune homeostasis and response, including discrimination between self- and non-self-antigens, containment of immunopathology, and inflammation resolution. These diverse functions are orchestrated by cellular circuits involving Tregs and other cell types across space and time. Despite dramatic progress in our understanding of Treg biology, a quantitative framework capturing how Treg-containing circuits give rise to these diverse functions is lacking. Here, we propose t...
Source: Trends in Immunology - September 10, 2023 Category: Allergy & Immunology Authors: Shubham Tripathi John S Tsang Kyemyung Park Source Type: research
HLA alleles: important pieces to the COVID-19 puzzle
Trends Immunol. 2023 Sep 9:S1471-4906(23)00179-5. doi: 10.1016/j.it.2023.08.011. Online ahead of print.ABSTRACTResearch on human leukocyte antigen (HLA) molecules in coronavirus disease 2019 (COVID-19) raised high expectations but has yielded limited results. Augusto et al.'s recent study in Nature unveils a strong association of HLA-B*15:01 with asymptomatic COVID-19, representing an important contribution to genetics in COVID-19.PMID:37690961 | DOI:10.1016/j.it.2023.08.011 (Source: Trends in Immunology)
Source: Trends in Immunology - September 10, 2023 Category: Allergy & Immunology Authors: Patricia Castro-Santos Ángel Carracedo Roberto D íaz-Peña Source Type: research
Systems immunology of regulatory T cells: can one circuit explain it all?
Trends Immunol. 2023 Sep 8:S1471-4906(23)00161-8. doi: 10.1016/j.it.2023.08.007. Online ahead of print.ABSTRACTRegulatory T (Treg) cells play vital roles in immune homeostasis and response, including discrimination between self- and non-self-antigens, containment of immunopathology, and inflammation resolution. These diverse functions are orchestrated by cellular circuits involving Tregs and other cell types across space and time. Despite dramatic progress in our understanding of Treg biology, a quantitative framework capturing how Treg-containing circuits give rise to these diverse functions is lacking. Here, we propose t...
Source: Trends in Immunology - September 10, 2023 Category: Allergy & Immunology Authors: Shubham Tripathi John S Tsang Kyemyung Park Source Type: research
HLA alleles: important pieces to the COVID-19 puzzle
Trends Immunol. 2023 Sep 9:S1471-4906(23)00179-5. doi: 10.1016/j.it.2023.08.011. Online ahead of print.ABSTRACTResearch on human leukocyte antigen (HLA) molecules in coronavirus disease 2019 (COVID-19) raised high expectations but has yielded limited results. Augusto et al.'s recent study in Nature unveils a strong association of HLA-B*15:01 with asymptomatic COVID-19, representing an important contribution to genetics in COVID-19.PMID:37690961 | DOI:10.1016/j.it.2023.08.011 (Source: Trends in Immunology)
Source: Trends in Immunology - September 10, 2023 Category: Allergy & Immunology Authors: Patricia Castro-Santos Ángel Carracedo Roberto D íaz-Peña Source Type: research
Systems immunology of regulatory T cells: can one circuit explain it all?
Trends Immunol. 2023 Sep 8:S1471-4906(23)00161-8. doi: 10.1016/j.it.2023.08.007. Online ahead of print.ABSTRACTRegulatory T (Treg) cells play vital roles in immune homeostasis and response, including discrimination between self- and non-self-antigens, containment of immunopathology, and inflammation resolution. These diverse functions are orchestrated by cellular circuits involving Tregs and other cell types across space and time. Despite dramatic progress in our understanding of Treg biology, a quantitative framework capturing how Treg-containing circuits give rise to these diverse functions is lacking. Here, we propose t...
Source: Trends in Immunology - September 10, 2023 Category: Allergy & Immunology Authors: Shubham Tripathi John S Tsang Kyemyung Park Source Type: research
Carbohydrates as putative pattern recognition receptor agonists in vaccine development
Trends Immunol. 2023 Sep 6:S1471-4906(23)00160-6. doi: 10.1016/j.it.2023.08.006. Online ahead of print.ABSTRACTAdjuvants are essential components of modern vaccines. One general mechanism underlying their immunostimulatory functions is the activation of pattern recognition receptors (PRRs) of innate immune cells. Carbohydrates - as essential signaling molecules on microbial surfaces - are potent PRR agonists and candidate materials for adjuvant design. Here, we summarize the latest trends in developing carbohydrate-containing adjuvants, with fresh opinions on how the physicochemical characteristics of the glycans (e.g., mo...
Source: Trends in Immunology - September 8, 2023 Category: Allergy & Immunology Authors: Ruoyu Mu Lei Dong Chunming Wang Source Type: research
Carbohydrates as putative pattern recognition receptor agonists in vaccine development
Trends Immunol. 2023 Sep 6:S1471-4906(23)00160-6. doi: 10.1016/j.it.2023.08.006. Online ahead of print.ABSTRACTAdjuvants are essential components of modern vaccines. One general mechanism underlying their immunostimulatory functions is the activation of pattern recognition receptors (PRRs) of innate immune cells. Carbohydrates - as essential signaling molecules on microbial surfaces - are potent PRR agonists and candidate materials for adjuvant design. Here, we summarize the latest trends in developing carbohydrate-containing adjuvants, with fresh opinions on how the physicochemical characteristics of the glycans (e.g., mo...
Source: Trends in Immunology - September 8, 2023 Category: Allergy & Immunology Authors: Ruoyu Mu Lei Dong Chunming Wang Source Type: research
CAR T cells ignite antitumor immunity
Trends Immunol. 2023 Aug 29:S1471-4906(23)00156-4. doi: 10.1016/j.it.2023.08.002. Online ahead of print.ABSTRACTBroadening immune responses through antigen spreading remains the 'Holy Grail' of cancer immunotherapy. A study by Ma and colleagues reveals that vaccine boosting of chimeric antigen receptor (CAR)-T cells in mice promotes endogenous immunity and elicits antigen spread to eliminate antigenically heterogenous solid tumors through a mechanism crucially dependent on interferon (IFN)γ.PMID:37652814 | DOI:10.1016/j.it.2023.08.002 (Source: Trends in Immunology)
Source: Trends in Immunology - August 31, 2023 Category: Allergy & Immunology Authors: Darya Alizadeh Christine E Brown Source Type: research
CAR T cells ignite antitumor immunity
Trends Immunol. 2023 Aug 29:S1471-4906(23)00156-4. doi: 10.1016/j.it.2023.08.002. Online ahead of print.ABSTRACTBroadening immune responses through antigen spreading remains the 'Holy Grail' of cancer immunotherapy. A study by Ma and colleagues reveals that vaccine boosting of chimeric antigen receptor (CAR)-T cells in mice promotes endogenous immunity and elicits antigen spread to eliminate antigenically heterogenous solid tumors through a mechanism crucially dependent on interferon (IFN)γ.PMID:37652814 | DOI:10.1016/j.it.2023.08.002 (Source: Trends in Immunology)
Source: Trends in Immunology - August 31, 2023 Category: Allergy & Immunology Authors: Darya Alizadeh Christine E Brown Source Type: research
CAR T cells ignite antitumor immunity
Trends Immunol. 2023 Aug 29:S1471-4906(23)00156-4. doi: 10.1016/j.it.2023.08.002. Online ahead of print.ABSTRACTBroadening immune responses through antigen spreading remains the 'Holy Grail' of cancer immunotherapy. A study by Ma and colleagues reveals that vaccine boosting of chimeric antigen receptor (CAR)-T cells in mice promotes endogenous immunity and elicits antigen spread to eliminate antigenically heterogenous solid tumors through a mechanism crucially dependent on interferon (IFN)γ.PMID:37652814 | DOI:10.1016/j.it.2023.08.002 (Source: Trends in Immunology)
Source: Trends in Immunology - August 31, 2023 Category: Allergy & Immunology Authors: Darya Alizadeh Christine E Brown Source Type: research
CAR T cells ignite antitumor immunity
Trends Immunol. 2023 Aug 29:S1471-4906(23)00156-4. doi: 10.1016/j.it.2023.08.002. Online ahead of print.ABSTRACTBroadening immune responses through antigen spreading remains the 'Holy Grail' of cancer immunotherapy. A study by Ma and colleagues reveals that vaccine boosting of chimeric antigen receptor (CAR)-T cells in mice promotes endogenous immunity and elicits antigen spread to eliminate antigenically heterogenous solid tumors through a mechanism crucially dependent on interferon (IFN)γ.PMID:37652814 | DOI:10.1016/j.it.2023.08.002 (Source: Trends in Immunology)
Source: Trends in Immunology - August 31, 2023 Category: Allergy & Immunology Authors: Darya Alizadeh Christine E Brown Source Type: research
CAR T cells ignite antitumor immunity
Trends Immunol. 2023 Aug 29:S1471-4906(23)00156-4. doi: 10.1016/j.it.2023.08.002. Online ahead of print.ABSTRACTBroadening immune responses through antigen spreading remains the 'Holy Grail' of cancer immunotherapy. A study by Ma and colleagues reveals that vaccine boosting of chimeric antigen receptor (CAR)-T cells in mice promotes endogenous immunity and elicits antigen spread to eliminate antigenically heterogenous solid tumors through a mechanism crucially dependent on interferon (IFN)γ.PMID:37652814 | DOI:10.1016/j.it.2023.08.002 (Source: Trends in Immunology)
Source: Trends in Immunology - August 31, 2023 Category: Allergy & Immunology Authors: Darya Alizadeh Christine E Brown Source Type: research
