CAR T cells ignite antitumor immunity

Trends Immunol. 2023 Aug 29:S1471-4906(23)00156-4. doi: 10.1016/j.it.2023.08.002. Online ahead of print.ABSTRACTBroadening immune responses through antigen spreading remains the 'Holy Grail' of cancer immunotherapy. A study by Ma and colleagues reveals that vaccine boosting of chimeric antigen receptor (CAR)-T cells in mice promotes endogenous immunity and elicits antigen spread to eliminate antigenically heterogenous solid tumors through a mechanism crucially dependent on interferon (IFN)γ.PMID:37652814 | DOI:10.1016/j.it.2023.08.002

Source: Trends in Immunology - August 31, 2023 Category: Allergy & Immunology Authors: Darya Alizadeh Christine E Brown Source Type: research