B cell phylogenetics in the single cell era
Trends Immunol. 2023 Dec 27:S1471-4906(23)00258-2. doi: 10.1016/j.it.2023.11.004. Online ahead of print.ABSTRACTThe widespread availability of single-cell RNA sequencing (scRNA-seq) has led to the development of new methods for understanding immune responses. Single-cell transcriptome data can now be paired with B cell receptor (BCR) sequences. However, RNA from BCRs cannot be analyzed like most other genes because BCRs are genetically diverse within individuals. In humans, BCRs are shaped through recombination followed by mutation and selection for antigen binding. As these processes co-occur with cell division, B cells c...
Source: Trends in Immunology - December 27, 2023 Category: Allergy & Immunology Authors: Kenneth B Hoehn Steven H Kleinstein Source Type: research
B cell phylogenetics in the single cell era
Trends Immunol. 2023 Dec 27:S1471-4906(23)00258-2. doi: 10.1016/j.it.2023.11.004. Online ahead of print.ABSTRACTThe widespread availability of single-cell RNA sequencing (scRNA-seq) has led to the development of new methods for understanding immune responses. Single-cell transcriptome data can now be paired with B cell receptor (BCR) sequences. However, RNA from BCRs cannot be analyzed like most other genes because BCRs are genetically diverse within individuals. In humans, BCRs are shaped through recombination followed by mutation and selection for antigen binding. As these processes co-occur with cell division, B cells c...
Source: Trends in Immunology - December 27, 2023 Category: Allergy & Immunology Authors: Kenneth B Hoehn Steven H Kleinstein Source Type: research
B cell phylogenetics in the single cell era
Trends Immunol. 2023 Dec 27:S1471-4906(23)00258-2. doi: 10.1016/j.it.2023.11.004. Online ahead of print.ABSTRACTThe widespread availability of single-cell RNA sequencing (scRNA-seq) has led to the development of new methods for understanding immune responses. Single-cell transcriptome data can now be paired with B cell receptor (BCR) sequences. However, RNA from BCRs cannot be analyzed like most other genes because BCRs are genetically diverse within individuals. In humans, BCRs are shaped through recombination followed by mutation and selection for antigen binding. As these processes co-occur with cell division, B cells c...
Source: Trends in Immunology - December 27, 2023 Category: Allergy & Immunology Authors: Kenneth B Hoehn Steven H Kleinstein Source Type: research
B cell phylogenetics in the single cell era
Trends Immunol. 2023 Dec 27:S1471-4906(23)00258-2. doi: 10.1016/j.it.2023.11.004. Online ahead of print.ABSTRACTThe widespread availability of single-cell RNA sequencing (scRNA-seq) has led to the development of new methods for understanding immune responses. Single-cell transcriptome data can now be paired with B cell receptor (BCR) sequences. However, RNA from BCRs cannot be analyzed like most other genes because BCRs are genetically diverse within individuals. In humans, BCRs are shaped through recombination followed by mutation and selection for antigen binding. As these processes co-occur with cell division, B cells c...
Source: Trends in Immunology - December 27, 2023 Category: Allergy & Immunology Authors: Kenneth B Hoehn Steven H Kleinstein Source Type: research
B cell phylogenetics in the single cell era
Trends Immunol. 2023 Dec 27:S1471-4906(23)00258-2. doi: 10.1016/j.it.2023.11.004. Online ahead of print.ABSTRACTThe widespread availability of single-cell RNA sequencing (scRNA-seq) has led to the development of new methods for understanding immune responses. Single-cell transcriptome data can now be paired with B cell receptor (BCR) sequences. However, RNA from BCRs cannot be analyzed like most other genes because BCRs are genetically diverse within individuals. In humans, BCRs are shaped through recombination followed by mutation and selection for antigen binding. As these processes co-occur with cell division, B cells c...
Source: Trends in Immunology - December 27, 2023 Category: Allergy & Immunology Authors: Kenneth B Hoehn Steven H Kleinstein Source Type: research
B cell phylogenetics in the single cell era
Trends Immunol. 2023 Dec 27:S1471-4906(23)00258-2. doi: 10.1016/j.it.2023.11.004. Online ahead of print.ABSTRACTThe widespread availability of single-cell RNA sequencing (scRNA-seq) has led to the development of new methods for understanding immune responses. Single-cell transcriptome data can now be paired with B cell receptor (BCR) sequences. However, RNA from BCRs cannot be analyzed like most other genes because BCRs are genetically diverse within individuals. In humans, BCRs are shaped through recombination followed by mutation and selection for antigen binding. As these processes co-occur with cell division, B cells c...
Source: Trends in Immunology - December 27, 2023 Category: Allergy & Immunology Authors: Kenneth B Hoehn Steven H Kleinstein Source Type: research
Double-take: SARS-CoV-2 has evolved to evade human innate immunity, twice
Trends Immunol. 2023 Dec 23:S1471-4906(23)00261-2. doi: 10.1016/j.it.2023.12.001. Online ahead of print.ABSTRACTSequential replacement of the dominant SARS-CoV-2 virus by new variants has been a striking feature of the COVID-19 pandemic. In two recent articles, Bouhaddou et al. and Kehrer et al. demonstrate that, like the original virus, the SARS-CoV-2 omicron strain has progressively evolved to evade host innate immune defenses.PMID:38143224 | DOI:10.1016/j.it.2023.12.001 (Source: Trends in Immunology)
Source: Trends in Immunology - December 24, 2023 Category: Allergy & Immunology Authors: Ellen F Foxman Source Type: research
Double-take: SARS-CoV-2 has evolved to evade human innate immunity, twice
Trends Immunol. 2023 Dec 23:S1471-4906(23)00261-2. doi: 10.1016/j.it.2023.12.001. Online ahead of print.ABSTRACTSequential replacement of the dominant SARS-CoV-2 virus by new variants has been a striking feature of the COVID-19 pandemic. In two recent articles, Bouhaddou et al. and Kehrer et al. demonstrate that, like the original virus, the SARS-CoV-2 omicron strain has progressively evolved to evade host innate immune defenses.PMID:38143224 | DOI:10.1016/j.it.2023.12.001 (Source: Trends in Immunology)
Source: Trends in Immunology - December 24, 2023 Category: Allergy & Immunology Authors: Ellen F Foxman Source Type: research
Double-take: SARS-CoV-2 has evolved to evade human innate immunity, twice
Trends Immunol. 2023 Dec 23:S1471-4906(23)00261-2. doi: 10.1016/j.it.2023.12.001. Online ahead of print.ABSTRACTSequential replacement of the dominant SARS-CoV-2 virus by new variants has been a striking feature of the COVID-19 pandemic. In two recent articles, Bouhaddou et al. and Kehrer et al. demonstrate that, like the original virus, the SARS-CoV-2 omicron strain has progressively evolved to evade host innate immune defenses.PMID:38143224 | DOI:10.1016/j.it.2023.12.001 (Source: Trends in Immunology)
Source: Trends in Immunology - December 24, 2023 Category: Allergy & Immunology Authors: Ellen F Foxman Source Type: research
The potential of mRNA vaccines in cancer nanomedicine and immunotherapy
Trends Immunol. 2023 Dec 22:S1471-4906(23)00257-0. doi: 10.1016/j.it.2023.11.003. Online ahead of print.ABSTRACTOwing to their outstanding performance against COVID-19, mRNA vaccines have brought great hope for combating various incurable diseases, including cancer. Differences in the encoded proteins result in different molecular and cellular mechanisms of mRNA vaccines. With the rapid development of nanotechnology and molecular medicine, personalized antigen-encoding mRNA vaccines that enhance antigen presentation can trigger effective immune responses and prevent off-target toxicities. Herein, we review new insights int...
Source: Trends in Immunology - December 23, 2023 Category: Allergy & Immunology Authors: Shulin Pan Rangrang Fan Bo Han Aiping Tong Gang Guo Source Type: research
The potential of mRNA vaccines in cancer nanomedicine and immunotherapy
Trends Immunol. 2023 Dec 22:S1471-4906(23)00257-0. doi: 10.1016/j.it.2023.11.003. Online ahead of print.ABSTRACTOwing to their outstanding performance against COVID-19, mRNA vaccines have brought great hope for combating various incurable diseases, including cancer. Differences in the encoded proteins result in different molecular and cellular mechanisms of mRNA vaccines. With the rapid development of nanotechnology and molecular medicine, personalized antigen-encoding mRNA vaccines that enhance antigen presentation can trigger effective immune responses and prevent off-target toxicities. Herein, we review new insights int...
Source: Trends in Immunology - December 23, 2023 Category: Allergy & Immunology Authors: Shulin Pan Rangrang Fan Bo Han Aiping Tong Gang Guo Source Type: research
The many ways in which alphaviruses bind to cells
Trends Immunol. 2023 Dec 22:S1471-4906(23)00260-0. doi: 10.1016/j.it.2023.11.006. Online ahead of print.ABSTRACTOnly a subset of viruses can productively infect many different host species. Some arthropod-transmitted viruses, such as alphaviruses, can infect invertebrate and vertebrate species including insects, reptiles, birds, and mammals. This broad tropism may be explained by their ability to engage receptors that are conserved across vertebrate and invertebrate classes. Through several genome-wide loss-of-function screens, new alphavirus receptors have been identified, some of which bind to multiple related viruses in...
Source: Trends in Immunology - December 22, 2023 Category: Allergy & Immunology Authors: Saravanan Raju Lucas J Adams Michael S Diamond Source Type: research
Modeling human immune responses to vaccination in vitro
Trends Immunol. 2023 Dec 21:S1471-4906(23)00256-9. doi: 10.1016/j.it.2023.11.002. Online ahead of print.ABSTRACTThe human immune system is a complex network of coordinated components that are crucial for health and disease. Animal models, commonly used to study immunomodulatory agents, are limited by species-specific differences, low throughput, and ethical concerns. In contrast, in vitro modeling of human immune responses can enable species- and population-specific mechanistic studies and translational development within the same study participant. Translational accuracy of in vitro models is enhanced by accounting for ge...
Source: Trends in Immunology - December 22, 2023 Category: Allergy & Immunology Authors: Elena Morrocchi Simon van Haren Paolo Palma Ofer Levy Source Type: research
Chimeric antigen receptor T < sub > reg < /sub > therapy in transplantation
Trends Immunol. 2023 Dec 19:S1471-4906(23)00259-4. doi: 10.1016/j.it.2023.11.005. Online ahead of print.ABSTRACTIn the quest for more precise and effective organ transplantation therapies, chimeric antigen receptor (CAR) regulatory T cell (Treg) therapies represent a potential cutting-edge advance. This review comprehensively analyses CAR Tregs and how they may address important drawbacks of polyclonal Tregs and conventional immunosuppressants. We examine a growing body of preclinical findings of CAR Treg therapy in transplantation, discuss CAR Treg design specifics, and explore established and attractive new targets in tr...
Source: Trends in Immunology - December 20, 2023 Category: Allergy & Immunology Authors: Siawosh K Eskandari Andrea Daccache Jamil R Azzi Source Type: research
Chimeric antigen receptor T < sub > reg < /sub > therapy in transplantation
Trends Immunol. 2023 Dec 19:S1471-4906(23)00259-4. doi: 10.1016/j.it.2023.11.005. Online ahead of print.ABSTRACTIn the quest for more precise and effective organ transplantation therapies, chimeric antigen receptor (CAR) regulatory T cell (Treg) therapies represent a potential cutting-edge advance. This review comprehensively analyses CAR Tregs and how they may address important drawbacks of polyclonal Tregs and conventional immunosuppressants. We examine a growing body of preclinical findings of CAR Treg therapy in transplantation, discuss CAR Treg design specifics, and explore established and attractive new targets in tr...
Source: Trends in Immunology - December 20, 2023 Category: Allergy & Immunology Authors: Siawosh K Eskandari Andrea Daccache Jamil R Azzi Source Type: research
