Do antigen-presenting CD1a, CD1b, CD1c, and CD1d molecules bind different self-lipids?

Trends Immunol. 2023 Oct;44(10):757-759. doi: 10.1016/j.it.2023.08.010. Epub 2023 Sep 18.ABSTRACTHumans express four different lipid antigen-presenting molecules, CD1a, CD1b, CD1c, and CD1d, that are differentially expressed on antigen-presenting cells and which recycle through different endosomal compartments. Huang et al. now answer the question on whether the four CD1 isoforms selectively bind certain lipids.PMID:37730500 | DOI:10.1016/j.it.2023.08.010

Source: Trends in Immunology - September 20, 2023 Category: Allergy & Immunology Authors: Ildiko Van Rhijn Source Type: research