cGAS-like receptors: back to the future

Trends Immunol. 2023 Sep 11:S1471-4906(23)00177-1. doi: 10.1016/j.it.2023.08.009. Online ahead of print.ABSTRACTRecent studies have characterized ancient forms of cyclic GMP-AMP (cGAMP) synthase (cGAS)-like receptors (cGLRs) in bacterial and Drosophila immunity. Using bioinformatics and biochemical screening, Li et al. recently constructed and characterized >3000 cGLRs to reveal conserved mechanisms of nucleic acid sensing across animal immunity.PMID:37718174 | DOI:10.1016/j.it.2023.08.009
Source: Trends in Immunology - Category: Allergy & Immunology Authors: Source Type: research