RNA circuits and RNA-binding proteins in T cells

Trends Immunol. 2023 Aug 18:S1471-4906(23)00153-9. doi: 10.1016/j.it.2023.07.006. Online ahead of print.ABSTRACTRNA is integral to the regulatory circuits that control cell identity and behavior. Cis-regulatory elements in mRNAs interact with RNA-binding proteins (RBPs) that can alter RNA sequence, stability, and translation into protein. Similarly, long noncoding RNAs (lncRNAs) scaffold ribonucleoprotein complexes that mediate transcriptional and post-transcriptional regulation of gene expression. Indeed, cell programming is fundamental to multicellular life and, in this era of cellular therapies, it is of particular interest in T cells. Here, we review key concepts and recent advances in our understanding of the RNA circuits and RBPs that govern mammalian T cell differentiation and immune function.PMID:37599172 | DOI:10.1016/j.it.2023.07.006

Source: Trends in Immunology - August 20, 2023 Category: Allergy & Immunology Authors: Wandi S Zhu Benjamin D Wheeler K Mark Ansel Source Type: research