From genome size to trait evolution during angiosperm radiation
Trends Genet. 2023 Aug 14:S0168-9525(23)00164-6. doi: 10.1016/j.tig.2023.07.006. Online ahead of print.ABSTRACTAngiosperm diversity arises from trait flexibility and repeated evolutionary radiations, but the role of genomic characters in these radiations remains unclear. In this opinion article, we discuss how genome size can influence angiosperm diversification via its intricate link with cell size, tissue packing, and physiological processes which, in turn, influence the macroevolution of functional traits. We propose that integrating genome size, functional traits, and phylogenetic data across a wide range of lineages a...
Source: Trends in Genetics : TIG - August 15, 2023 Category: Genetics & Stem Cells Authors: Sreetama Bhadra Ilia J Leitch Renske E Onstein Source Type: research
From genome size to trait evolution during angiosperm radiation
Trends Genet. 2023 Aug 14:S0168-9525(23)00164-6. doi: 10.1016/j.tig.2023.07.006. Online ahead of print.ABSTRACTAngiosperm diversity arises from trait flexibility and repeated evolutionary radiations, but the role of genomic characters in these radiations remains unclear. In this opinion article, we discuss how genome size can influence angiosperm diversification via its intricate link with cell size, tissue packing, and physiological processes which, in turn, influence the macroevolution of functional traits. We propose that integrating genome size, functional traits, and phylogenetic data across a wide range of lineages a...
Source: Trends in Genetics : TIG - August 15, 2023 Category: Genetics & Stem Cells Authors: Sreetama Bhadra Ilia J Leitch Renske E Onstein Source Type: research
From genome size to trait evolution during angiosperm radiation
Trends Genet. 2023 Aug 14:S0168-9525(23)00164-6. doi: 10.1016/j.tig.2023.07.006. Online ahead of print.ABSTRACTAngiosperm diversity arises from trait flexibility and repeated evolutionary radiations, but the role of genomic characters in these radiations remains unclear. In this opinion article, we discuss how genome size can influence angiosperm diversification via its intricate link with cell size, tissue packing, and physiological processes which, in turn, influence the macroevolution of functional traits. We propose that integrating genome size, functional traits, and phylogenetic data across a wide range of lineages a...
Source: Trends in Genetics : TIG - August 15, 2023 Category: Genetics & Stem Cells Authors: Sreetama Bhadra Ilia J Leitch Renske E Onstein Source Type: research
Hitting the brakes on transcription to extend lifespan
Trends Genet. 2023 Aug 11:S0168-9525(23)00165-8. doi: 10.1016/j.tig.2023.07.007. Online ahead of print.ABSTRACTIn aged animals from worms to humans, transcriptional elongation rates are faster, leading to changes in transcript quality and alternative splicing. Recent work by Debès et al. shows how interventions that slow elongation rates, such as mutating RNA polymerase II (Pol II) or increasing nucleosome density to impose transcriptional 'traffic', delay senescence and promote longevity.PMID:37574379 | DOI:10.1016/j.tig.2023.07.007 (Source: Trends in Genetics : TIG)
Source: Trends in Genetics : TIG - August 13, 2023 Category: Genetics & Stem Cells Authors: Kristopher Burkewitz Source Type: research
Hitting the brakes on transcription to extend lifespan
Trends Genet. 2023 Aug 11:S0168-9525(23)00165-8. doi: 10.1016/j.tig.2023.07.007. Online ahead of print.ABSTRACTIn aged animals from worms to humans, transcriptional elongation rates are faster, leading to changes in transcript quality and alternative splicing. Recent work by Debès et al. shows how interventions that slow elongation rates, such as mutating RNA polymerase II (Pol II) or increasing nucleosome density to impose transcriptional 'traffic', delay senescence and promote longevity.PMID:37574379 | DOI:10.1016/j.tig.2023.07.007 (Source: Trends in Genetics : TIG)
Source: Trends in Genetics : TIG - August 13, 2023 Category: Genetics & Stem Cells Authors: Kristopher Burkewitz Source Type: research
Reference genome facilitates trait development for faba beans
Trends Genet. 2023 Aug 8:S0168-9525(23)00161-0. doi: 10.1016/j.tig.2023.07.003. Online ahead of print.ABSTRACTReference genomes facilitate trait improvement by aiding in the elucidation of causal genetic elements. Thanks to the recent release of a reference sequence for the faba bean, breeders and geneticists are poised to accelerate precision breeding and genetic improvement of this important crop.PMID:37563056 | DOI:10.1016/j.tig.2023.07.003 (Source: Trends in Genetics : TIG)
Source: Trends in Genetics : TIG - August 10, 2023 Category: Genetics & Stem Cells Authors: Aasim Majeed Ling Kui Yang Dong Jian Chen Source Type: research
Reference genome facilitates trait development for faba beans
Trends Genet. 2023 Aug 8:S0168-9525(23)00161-0. doi: 10.1016/j.tig.2023.07.003. Online ahead of print.ABSTRACTReference genomes facilitate trait improvement by aiding in the elucidation of causal genetic elements. Thanks to the recent release of a reference sequence for the faba bean, breeders and geneticists are poised to accelerate precision breeding and genetic improvement of this important crop.PMID:37563056 | DOI:10.1016/j.tig.2023.07.003 (Source: Trends in Genetics : TIG)
Source: Trends in Genetics : TIG - August 10, 2023 Category: Genetics & Stem Cells Authors: Aasim Majeed Ling Kui Yang Dong Jian Chen Source Type: research
Reference genome facilitates trait development for faba beans
Trends Genet. 2023 Aug 8:S0168-9525(23)00161-0. doi: 10.1016/j.tig.2023.07.003. Online ahead of print.ABSTRACTReference genomes facilitate trait improvement by aiding in the elucidation of causal genetic elements. Thanks to the recent release of a reference sequence for the faba bean, breeders and geneticists are poised to accelerate precision breeding and genetic improvement of this important crop.PMID:37563056 | DOI:10.1016/j.tig.2023.07.003 (Source: Trends in Genetics : TIG)
Source: Trends in Genetics : TIG - August 10, 2023 Category: Genetics & Stem Cells Authors: Aasim Majeed Ling Kui Yang Dong Jian Chen Source Type: research
Genetic distance informs polygenic score predictive accuracy
Trends Genet. 2023 Jul 29:S0168-9525(23)00160-9. doi: 10.1016/j.tig.2023.07.002. Online ahead of print.ABSTRACTPolygenic scores (PGSs) aggregate the effects of variants across the genome to estimate genetic liability, but have lower performance in external study populations. A new study by Ding et al. has applied a novel framework to estimate the individual-level predictive accuracy of PGSs, and demonstrates that performance reduction occurs linearly with genetic distance.PMID:37524625 | DOI:10.1016/j.tig.2023.07.002 (Source: Trends in Genetics : TIG)
Source: Trends in Genetics : TIG - July 31, 2023 Category: Genetics & Stem Cells Authors: Genevieve L Wojcik Source Type: research
Genetic distance informs polygenic score predictive accuracy
Trends Genet. 2023 Jul 29:S0168-9525(23)00160-9. doi: 10.1016/j.tig.2023.07.002. Online ahead of print.ABSTRACTPolygenic scores (PGSs) aggregate the effects of variants across the genome to estimate genetic liability, but have lower performance in external study populations. A new study by Ding et al. has applied a novel framework to estimate the individual-level predictive accuracy of PGSs, and demonstrates that performance reduction occurs linearly with genetic distance.PMID:37524625 | DOI:10.1016/j.tig.2023.07.002 (Source: Trends in Genetics : TIG)
Source: Trends in Genetics : TIG - July 31, 2023 Category: Genetics & Stem Cells Authors: Genevieve L Wojcik Source Type: research
Genetic distance informs polygenic score predictive accuracy
Trends Genet. 2023 Jul 29:S0168-9525(23)00160-9. doi: 10.1016/j.tig.2023.07.002. Online ahead of print.ABSTRACTPolygenic scores (PGSs) aggregate the effects of variants across the genome to estimate genetic liability, but have lower performance in external study populations. A new study by Ding et al. has applied a novel framework to estimate the individual-level predictive accuracy of PGSs, and demonstrates that performance reduction occurs linearly with genetic distance.PMID:37524625 | DOI:10.1016/j.tig.2023.07.002 (Source: Trends in Genetics : TIG)
Source: Trends in Genetics : TIG - July 31, 2023 Category: Genetics & Stem Cells Authors: Genevieve L Wojcik Source Type: research
Genetic distance informs polygenic score predictive accuracy
Trends Genet. 2023 Jul 29:S0168-9525(23)00160-9. doi: 10.1016/j.tig.2023.07.002. Online ahead of print.ABSTRACTPolygenic scores (PGSs) aggregate the effects of variants across the genome to estimate genetic liability, but have lower performance in external study populations. A new study by Ding et al. has applied a novel framework to estimate the individual-level predictive accuracy of PGSs, and demonstrates that performance reduction occurs linearly with genetic distance.PMID:37524625 | DOI:10.1016/j.tig.2023.07.002 (Source: Trends in Genetics : TIG)
Source: Trends in Genetics : TIG - July 31, 2023 Category: Genetics & Stem Cells Authors: Genevieve L Wojcik Source Type: research
Genetic distance informs polygenic score predictive accuracy
Trends Genet. 2023 Jul 29:S0168-9525(23)00160-9. doi: 10.1016/j.tig.2023.07.002. Online ahead of print.ABSTRACTPolygenic scores (PGSs) aggregate the effects of variants across the genome to estimate genetic liability, but have lower performance in external study populations. A new study by Ding et al. has applied a novel framework to estimate the individual-level predictive accuracy of PGSs, and demonstrates that performance reduction occurs linearly with genetic distance.PMID:37524625 | DOI:10.1016/j.tig.2023.07.002 (Source: Trends in Genetics : TIG)
Source: Trends in Genetics : TIG - July 31, 2023 Category: Genetics & Stem Cells Authors: Genevieve L Wojcik Source Type: research
Genetic distance informs polygenic score predictive accuracy
Trends Genet. 2023 Jul 29:S0168-9525(23)00160-9. doi: 10.1016/j.tig.2023.07.002. Online ahead of print.ABSTRACTPolygenic scores (PGSs) aggregate the effects of variants across the genome to estimate genetic liability, but have lower performance in external study populations. A new study by Ding et al. has applied a novel framework to estimate the individual-level predictive accuracy of PGSs, and demonstrates that performance reduction occurs linearly with genetic distance.PMID:37524625 | DOI:10.1016/j.tig.2023.07.002 (Source: Trends in Genetics : TIG)
Source: Trends in Genetics : TIG - July 31, 2023 Category: Genetics & Stem Cells Authors: Genevieve L Wojcik Source Type: research
Genetic distance informs polygenic score predictive accuracy
Trends Genet. 2023 Jul 29:S0168-9525(23)00160-9. doi: 10.1016/j.tig.2023.07.002. Online ahead of print.ABSTRACTPolygenic scores (PGSs) aggregate the effects of variants across the genome to estimate genetic liability, but have lower performance in external study populations. A new study by Ding et al. has applied a novel framework to estimate the individual-level predictive accuracy of PGSs, and demonstrates that performance reduction occurs linearly with genetic distance.PMID:37524625 | DOI:10.1016/j.tig.2023.07.002 (Source: Trends in Genetics : TIG)
Source: Trends in Genetics : TIG - July 31, 2023 Category: Genetics & Stem Cells Authors: Genevieve L Wojcik Source Type: research
