Hitting the brakes on transcription to extend lifespan

Trends Genet. 2023 Aug 11:S0168-9525(23)00165-8. doi: 10.1016/j.tig.2023.07.007. Online ahead of print.ABSTRACTIn aged animals from worms to humans, transcriptional elongation rates are faster, leading to changes in transcript quality and alternative splicing. Recent work by Debès et al. shows how interventions that slow elongation rates, such as mutating RNA polymerase II (Pol II) or increasing nucleosome density to impose transcriptional 'traffic', delay senescence and promote longevity.PMID:37574379 | DOI:10.1016/j.tig.2023.07.007

Source: Trends in Genetics : TIG - August 13, 2023 Category: Genetics & Stem Cells Authors: Kristopher Burkewitz Source Type: research