Take a walk on the KRAB side
Trends Genet. 2023 Sep 14:S0168-9525(23)00185-3. doi: 10.1016/j.tig.2023.08.003. Online ahead of print.ABSTRACTCanonical Krüppel-associated box (KRAB)-containing zinc finger proteins (KZFPs) act as major repressors of transposable elements (TEs) via the KRAB-mediated recruitment of the heterochromatin scaffold KRAB-associated protein (KAP)1. KZFP genes emerged some 420 million years ago in the last common ancestor of coelacanth, lungfish, and tetrapods, and dramatically expanded to give rise to lineage-specific repertoires in contemporary species paralleling their TE load and turnover. However, the KRAB domain displays se...
Source: Trends in Genetics : TIG - September 16, 2023 Category: Genetics & Stem Cells Authors: Olga Rosspopoff Didier Trono Source Type: research
Take a walk on the KRAB side
Trends Genet. 2023 Sep 14:S0168-9525(23)00185-3. doi: 10.1016/j.tig.2023.08.003. Online ahead of print.ABSTRACTCanonical Krüppel-associated box (KRAB)-containing zinc finger proteins (KZFPs) act as major repressors of transposable elements (TEs) via the KRAB-mediated recruitment of the heterochromatin scaffold KRAB-associated protein (KAP)1. KZFP genes emerged some 420 million years ago in the last common ancestor of coelacanth, lungfish, and tetrapods, and dramatically expanded to give rise to lineage-specific repertoires in contemporary species paralleling their TE load and turnover. However, the KRAB domain displays se...
Source: Trends in Genetics : TIG - September 16, 2023 Category: Genetics & Stem Cells Authors: Olga Rosspopoff Didier Trono Source Type: research
The evolution of aging and lifespan
Trends Genet. 2023 Sep 14:S0168-9525(23)00186-5. doi: 10.1016/j.tig.2023.08.005. Online ahead of print.ABSTRACTAging is a nearly inescapable trait among organisms yet lifespan varies tremendously across different species and spans several orders of magnitude in vertebrates alone. This vast phenotypic diversity is driven by distinct evolutionary trajectories and tradeoffs that are reflected in patterns of diversification and constraint in organismal genomes. Age-specific impacts of selection also shape allele frequencies in populations, thus impacting disease susceptibility and environment-specific mortality risk. Further, ...
Source: Trends in Genetics : TIG - September 15, 2023 Category: Genetics & Stem Cells Authors: Stacy Li Juan Manuel Vazquez Peter H Sudmant Source Type: research
Whole-genome doubling in tissues and tumors
Trends Genet. 2023 Sep 13:S0168-9525(23)00187-7. doi: 10.1016/j.tig.2023.08.004. Online ahead of print.ABSTRACTThe overwhelming majority of proliferating somatic human cells are diploid, and this genomic state is typically maintained across successive cell divisions. However, failures in cell division can induce a whole-genome doubling (WGD) event, in which diploid cells transition to a tetraploid state. While some WGDs are developmentally programmed to produce nonproliferative tetraploid cells with specific cellular functions, unscheduled WGDs can be catastrophic: erroneously arising tetraploid cells are ill-equipped to c...
Source: Trends in Genetics : TIG - September 15, 2023 Category: Genetics & Stem Cells Authors: Marc A Vittoria Ryan J Quinton Neil J Ganem Source Type: research
The African Society of Human Genetics successfully launches global data science workshops
We describe the first African genomics data science workshop, implemented by the African Society of Human Genetics (AfSHG) and international partners, providing a framework for future workshops.PMID:37714735 | DOI:10.1016/j.tig.2023.06.004 (Source: Trends in Genetics : TIG)
Source: Trends in Genetics : TIG - September 15, 2023 Category: Genetics & Stem Cells Authors: Victoria Nembaware Declan Bennett Emile R Chimusa Tinashe Chikowore Richard Daodu Valential Ngo Bitoungui Scott M Williams Segun Fatumo Sandra Healy Cathal Seoighe Ambroise Wonkam African Society of Human Genetics Source Type: research
The evolution of aging and lifespan
Trends Genet. 2023 Sep 14:S0168-9525(23)00186-5. doi: 10.1016/j.tig.2023.08.005. Online ahead of print.ABSTRACTAging is a nearly inescapable trait among organisms yet lifespan varies tremendously across different species and spans several orders of magnitude in vertebrates alone. This vast phenotypic diversity is driven by distinct evolutionary trajectories and tradeoffs that are reflected in patterns of diversification and constraint in organismal genomes. Age-specific impacts of selection also shape allele frequencies in populations, thus impacting disease susceptibility and environment-specific mortality risk. Further, ...
Source: Trends in Genetics : TIG - September 15, 2023 Category: Genetics & Stem Cells Authors: Stacy Li Juan Manuel Vazquez Peter H Sudmant Source Type: research
Whole-genome doubling in tissues and tumors
Trends Genet. 2023 Sep 13:S0168-9525(23)00187-7. doi: 10.1016/j.tig.2023.08.004. Online ahead of print.ABSTRACTThe overwhelming majority of proliferating somatic human cells are diploid, and this genomic state is typically maintained across successive cell divisions. However, failures in cell division can induce a whole-genome doubling (WGD) event, in which diploid cells transition to a tetraploid state. While some WGDs are developmentally programmed to produce nonproliferative tetraploid cells with specific cellular functions, unscheduled WGDs can be catastrophic: erroneously arising tetraploid cells are ill-equipped to c...
Source: Trends in Genetics : TIG - September 15, 2023 Category: Genetics & Stem Cells Authors: Marc A Vittoria Ryan J Quinton Neil J Ganem Source Type: research
The African Society of Human Genetics successfully launches global data science workshops
We describe the first African genomics data science workshop, implemented by the African Society of Human Genetics (AfSHG) and international partners, providing a framework for future workshops.PMID:37714735 | DOI:10.1016/j.tig.2023.06.004 (Source: Trends in Genetics : TIG)
Source: Trends in Genetics : TIG - September 15, 2023 Category: Genetics & Stem Cells Authors: Victoria Nembaware Declan Bennett Emile R Chimusa Tinashe Chikowore Richard Daodu Valential Ngo Bitoungui Scott M Williams Segun Fatumo Sandra Healy Cathal Seoighe Ambroise Wonkam African Society of Human Genetics Source Type: research
The searchable chromosome
Trends Genet. 2023 Sep 8:S0168-9525(23)00188-9. doi: 10.1016/j.tig.2023.08.006. Online ahead of print.ABSTRACTTo date, genome structure and dynamics have been studied mostly independently; their interplay is a notable blind spot of the field. Brückner, Chen, et al. recently demonstrated an integrated experimental approach sensitive to both, uncovering a striking robustness of enhancer-promoter search times (dynamics) to changes in genomic separation (structure).PMID:37690888 | DOI:10.1016/j.tig.2023.08.006 (Source: Trends in Genetics : TIG)
Source: Trends in Genetics : TIG - September 10, 2023 Category: Genetics & Stem Cells Authors: Simon Grosse-Holz Source Type: research
The searchable chromosome
Trends Genet. 2023 Sep 8:S0168-9525(23)00188-9. doi: 10.1016/j.tig.2023.08.006. Online ahead of print.ABSTRACTTo date, genome structure and dynamics have been studied mostly independently; their interplay is a notable blind spot of the field. Brückner, Chen, et al. recently demonstrated an integrated experimental approach sensitive to both, uncovering a striking robustness of enhancer-promoter search times (dynamics) to changes in genomic separation (structure).PMID:37690888 | DOI:10.1016/j.tig.2023.08.006 (Source: Trends in Genetics : TIG)
Source: Trends in Genetics : TIG - September 10, 2023 Category: Genetics & Stem Cells Authors: Simon Grosse-Holz Source Type: research
The searchable chromosome
Trends Genet. 2023 Sep 8:S0168-9525(23)00188-9. doi: 10.1016/j.tig.2023.08.006. Online ahead of print.ABSTRACTTo date, genome structure and dynamics have been studied mostly independently; their interplay is a notable blind spot of the field. Brückner, Chen, et al. recently demonstrated an integrated experimental approach sensitive to both, uncovering a striking robustness of enhancer-promoter search times (dynamics) to changes in genomic separation (structure).PMID:37690888 | DOI:10.1016/j.tig.2023.08.006 (Source: Trends in Genetics : TIG)
Source: Trends in Genetics : TIG - September 10, 2023 Category: Genetics & Stem Cells Authors: Simon Grosse-Holz Source Type: research
The searchable chromosome
Trends Genet. 2023 Sep 8:S0168-9525(23)00188-9. doi: 10.1016/j.tig.2023.08.006. Online ahead of print.ABSTRACTTo date, genome structure and dynamics have been studied mostly independently; their interplay is a notable blind spot of the field. Brückner, Chen, et al. recently demonstrated an integrated experimental approach sensitive to both, uncovering a striking robustness of enhancer-promoter search times (dynamics) to changes in genomic separation (structure).PMID:37690888 | DOI:10.1016/j.tig.2023.08.006 (Source: Trends in Genetics : TIG)
Source: Trends in Genetics : TIG - September 10, 2023 Category: Genetics & Stem Cells Authors: Simon Grosse-Holz Source Type: research
Dynamics of the Streptomyces chromosome: chance and necessity
Trends Genet. 2023 Sep 5:S0168-9525(23)00166-X. doi: 10.1016/j.tig.2023.07.008. Online ahead of print.ABSTRACTStreptomyces are prolific producers of specialized metabolites with applications in medicine and agriculture. Remarkably, these bacteria possess a large linear chromosome that is genetically compartmentalized: core genes are grouped in the central part, while the ends are populated by poorly conserved genes including antibiotic biosynthetic gene clusters. The genome is highly unstable and exhibits distinct evolutionary rates along the chromosome. Recent chromosome conformation capture (3C) and comparative genomics ...
Source: Trends in Genetics : TIG - September 7, 2023 Category: Genetics & Stem Cells Authors: St éphanie Bury-Moné Annabelle Thibessard Virginia S Lioy Pierre Leblond Source Type: research
Dynamics of the Streptomyces chromosome: chance and necessity
Trends Genet. 2023 Sep 5:S0168-9525(23)00166-X. doi: 10.1016/j.tig.2023.07.008. Online ahead of print.ABSTRACTStreptomyces are prolific producers of specialized metabolites with applications in medicine and agriculture. Remarkably, these bacteria possess a large linear chromosome that is genetically compartmentalized: core genes are grouped in the central part, while the ends are populated by poorly conserved genes including antibiotic biosynthetic gene clusters. The genome is highly unstable and exhibits distinct evolutionary rates along the chromosome. Recent chromosome conformation capture (3C) and comparative genomics ...
Source: Trends in Genetics : TIG - September 7, 2023 Category: Genetics & Stem Cells Authors: St éphanie Bury-Moné Annabelle Thibessard Virginia S Lioy Pierre Leblond Source Type: research
Dynamics of the Streptomyces chromosome: chance and necessity
Trends Genet. 2023 Sep 5:S0168-9525(23)00166-X. doi: 10.1016/j.tig.2023.07.008. Online ahead of print.ABSTRACTStreptomyces are prolific producers of specialized metabolites with applications in medicine and agriculture. Remarkably, these bacteria possess a large linear chromosome that is genetically compartmentalized: core genes are grouped in the central part, while the ends are populated by poorly conserved genes including antibiotic biosynthetic gene clusters. The genome is highly unstable and exhibits distinct evolutionary rates along the chromosome. Recent chromosome conformation capture (3C) and comparative genomics ...
Source: Trends in Genetics : TIG - September 7, 2023 Category: Genetics & Stem Cells Authors: St éphanie Bury-Moné Annabelle Thibessard Virginia S Lioy Pierre Leblond Source Type: research
