A dive into the unknome
Trends Genet. 2023 Nov 13:S0168-9525(23)00239-1. doi: 10.1016/j.tig.2023.10.011. Online ahead of print.ABSTRACTWe may never understand the function of all genes, findings by Freeman, Munro and colleagues Rocha et al. suggest, unless we rethink our approaches. They make a thorough attempt at quantifying the unknownness of protein-coding genes and experimentally prove that many neglected genes hold the seed of important discoveries.PMID:37968205 | DOI:10.1016/j.tig.2023.10.011 (Source: Trends in Genetics : TIG)
Source: Trends in Genetics : TIG - November 15, 2023 Category: Genetics & Stem Cells Authors: Juri Rappsilber Source Type: research
A dive into the unknome
Trends Genet. 2023 Nov 13:S0168-9525(23)00239-1. doi: 10.1016/j.tig.2023.10.011. Online ahead of print.ABSTRACTWe may never understand the function of all genes, findings by Freeman, Munro and colleagues Rocha et al. suggest, unless we rethink our approaches. They make a thorough attempt at quantifying the unknownness of protein-coding genes and experimentally prove that many neglected genes hold the seed of important discoveries.PMID:37968205 | DOI:10.1016/j.tig.2023.10.011 (Source: Trends in Genetics : TIG)
Source: Trends in Genetics : TIG - November 15, 2023 Category: Genetics & Stem Cells Authors: Juri Rappsilber Source Type: research
A dive into the unknome
Trends Genet. 2023 Nov 13:S0168-9525(23)00239-1. doi: 10.1016/j.tig.2023.10.011. Online ahead of print.ABSTRACTWe may never understand the function of all genes, findings by Freeman, Munro and colleagues Rocha et al. suggest, unless we rethink our approaches. They make a thorough attempt at quantifying the unknownness of protein-coding genes and experimentally prove that many neglected genes hold the seed of important discoveries.PMID:37968205 | DOI:10.1016/j.tig.2023.10.011 (Source: Trends in Genetics : TIG)
Source: Trends in Genetics : TIG - November 15, 2023 Category: Genetics & Stem Cells Authors: Juri Rappsilber Source Type: research
Genome stability from the perspective of telomere length
Trends Genet. 2023 Nov 11:S0168-9525(23)00241-X. doi: 10.1016/j.tig.2023.10.013. Online ahead of print.ABSTRACTTelomeres and their associated proteins protect the ends of chromosomes to maintain genome stability. Telomeres undergo progressive shortening with each cell division in mammalian somatic cells without telomerase, resulting in genome instability. When telomeres reach a critically short length or are recognized as a damage signal, cells enter a state of senescence, followed by cell cycle arrest, programmed cell death, or immortalization. This review provides an overview of recent advances in the intricate relations...
Source: Trends in Genetics : TIG - November 13, 2023 Category: Genetics & Stem Cells Authors: Xinyi Lu Lin Liu Source Type: research
Genome stability from the perspective of telomere length
Trends Genet. 2023 Nov 11:S0168-9525(23)00241-X. doi: 10.1016/j.tig.2023.10.013. Online ahead of print.ABSTRACTTelomeres and their associated proteins protect the ends of chromosomes to maintain genome stability. Telomeres undergo progressive shortening with each cell division in mammalian somatic cells without telomerase, resulting in genome instability. When telomeres reach a critically short length or are recognized as a damage signal, cells enter a state of senescence, followed by cell cycle arrest, programmed cell death, or immortalization. This review provides an overview of recent advances in the intricate relations...
Source: Trends in Genetics : TIG - November 13, 2023 Category: Genetics & Stem Cells Authors: Xinyi Lu Lin Liu Source Type: research
Alternative paths for genetics, then and now: Q & amp;A with Gregory Radick about Disputed Inheritance
Trends Genet. 2023 Nov 10:S0168-9525(23)00233-0. doi: 10.1016/j.tig.2023.10.005. Online ahead of print.NO ABSTRACTPMID:37953194 | DOI:10.1016/j.tig.2023.10.005 (Source: Trends in Genetics : TIG)
Source: Trends in Genetics : TIG - November 12, 2023 Category: Genetics & Stem Cells Authors: Gregory Radick Source Type: research
Opportunities and tradeoffs in single-cell transcriptomic technologies
Trends Genet. 2023 Nov 10:S0168-9525(23)00231-7. doi: 10.1016/j.tig.2023.10.003. Online ahead of print.ABSTRACTRecent technological and algorithmic advances enable single-cell transcriptomic analysis with remarkable depth and breadth. Nonetheless, a persistent challenge is the compromise between the ability to profile high numbers of cells and the achievement of full-length transcript coverage. Currently, the field is progressing and developing new and creative solutions that improve cellular throughput, gene detection sensitivity and full-length transcript capture. Furthermore, long-read sequencing approaches for single-c...
Source: Trends in Genetics : TIG - November 12, 2023 Category: Genetics & Stem Cells Authors: Matilde I Conte Azahara Fuentes-Trillo Cecilia Dom ínguez Conde Source Type: research
Alternative paths for genetics, then and now: Q & amp;A with Gregory Radick about Disputed Inheritance
Trends Genet. 2023 Nov 10:S0168-9525(23)00233-0. doi: 10.1016/j.tig.2023.10.005. Online ahead of print.NO ABSTRACTPMID:37953194 | DOI:10.1016/j.tig.2023.10.005 (Source: Trends in Genetics : TIG)
Source: Trends in Genetics : TIG - November 12, 2023 Category: Genetics & Stem Cells Authors: Gregory Radick Source Type: research
Opportunities and tradeoffs in single-cell transcriptomic technologies
Trends Genet. 2023 Nov 10:S0168-9525(23)00231-7. doi: 10.1016/j.tig.2023.10.003. Online ahead of print.ABSTRACTRecent technological and algorithmic advances enable single-cell transcriptomic analysis with remarkable depth and breadth. Nonetheless, a persistent challenge is the compromise between the ability to profile high numbers of cells and the achievement of full-length transcript coverage. Currently, the field is progressing and developing new and creative solutions that improve cellular throughput, gene detection sensitivity and full-length transcript capture. Furthermore, long-read sequencing approaches for single-c...
Source: Trends in Genetics : TIG - November 12, 2023 Category: Genetics & Stem Cells Authors: Matilde I Conte Azahara Fuentes-Trillo Cecilia Dom ínguez Conde Source Type: research
Strategies for dissecting the complexity of neurodevelopmental disorders
Trends Genet. 2023 Nov 8:S0168-9525(23)00237-8. doi: 10.1016/j.tig.2023.10.009. Online ahead of print.ABSTRACTNeurodevelopmental disorders (NDDs) are associated with a wide range of clinical features, affecting multiple pathways involved in brain development and function. Recent advances in high-throughput sequencing have unveiled numerous genetic variants associated with NDDs, which further contribute to disease complexity and make it challenging to infer disease causation and underlying mechanisms. Herein, we review current strategies for dissecting the complexity of NDDs using model organisms, induced pluripotent stem c...
Source: Trends in Genetics : TIG - November 10, 2023 Category: Genetics & Stem Cells Authors: Jiawan Sun Serena Noss Deepro Banerjee Maitreya Das Santhosh Girirajan Source Type: research
Retrotransposon renaissance in early embryos
Trends Genet. 2023 Nov 8:S0168-9525(23)00238-X. doi: 10.1016/j.tig.2023.10.010. Online ahead of print.ABSTRACTDespite being the predominant genetic elements in mammalian genomes, retrotransposons were often dismissed as genomic parasites with ambiguous biological significance. However, recent studies reveal their functional involvement in early embryogenesis, encompassing crucial processes such as zygotic genome activation (ZGA) and cell fate decision. This review underscores the paradigm shift in our understanding of retrotransposon roles during early preimplantation development, as well as their rich functional reservoir...
Source: Trends in Genetics : TIG - November 10, 2023 Category: Genetics & Stem Cells Authors: Youjia Guo Ten D Li Andrew J Modzelewski Haruhiko Siomi Source Type: research
Strategies for dissecting the complexity of neurodevelopmental disorders
Trends Genet. 2023 Nov 8:S0168-9525(23)00237-8. doi: 10.1016/j.tig.2023.10.009. Online ahead of print.ABSTRACTNeurodevelopmental disorders (NDDs) are associated with a wide range of clinical features, affecting multiple pathways involved in brain development and function. Recent advances in high-throughput sequencing have unveiled numerous genetic variants associated with NDDs, which further contribute to disease complexity and make it challenging to infer disease causation and underlying mechanisms. Herein, we review current strategies for dissecting the complexity of NDDs using model organisms, induced pluripotent stem c...
Source: Trends in Genetics : TIG - November 10, 2023 Category: Genetics & Stem Cells Authors: Jiawan Sun Serena Noss Deepro Banerjee Maitreya Das Santhosh Girirajan Source Type: research
Retrotransposon renaissance in early embryos
Trends Genet. 2023 Nov 8:S0168-9525(23)00238-X. doi: 10.1016/j.tig.2023.10.010. Online ahead of print.ABSTRACTDespite being the predominant genetic elements in mammalian genomes, retrotransposons were often dismissed as genomic parasites with ambiguous biological significance. However, recent studies reveal their functional involvement in early embryogenesis, encompassing crucial processes such as zygotic genome activation (ZGA) and cell fate decision. This review underscores the paradigm shift in our understanding of retrotransposon roles during early preimplantation development, as well as their rich functional reservoir...
Source: Trends in Genetics : TIG - November 10, 2023 Category: Genetics & Stem Cells Authors: Youjia Guo Ten D Li Andrew J Modzelewski Haruhiko Siomi Source Type: research
Pioneer factors: roles and their regulation in development
Trends Genet. 2023 Nov 6:S0168-9525(23)00235-4. doi: 10.1016/j.tig.2023.10.007. Online ahead of print.ABSTRACTPioneer factors are a subclass of transcription factors that can bind and initiate opening of silent chromatin regions. Pioneer factors subsequently regulate lineage-specific genes and enhancers and, thus, activate the zygotic genome after fertilization, guide cell fate transitions during development, and promote various forms of human cancers. As such, pioneer factors are useful in directed cell reprogramming. In this review, we define the structural and functional characteristics of pioneer factors, how they bind...
Source: Trends in Genetics : TIG - November 8, 2023 Category: Genetics & Stem Cells Authors: Amandine Barral Kenneth S Zaret Source Type: research
Pioneer factors: roles and their regulation in development
Trends Genet. 2023 Nov 6:S0168-9525(23)00235-4. doi: 10.1016/j.tig.2023.10.007. Online ahead of print.ABSTRACTPioneer factors are a subclass of transcription factors that can bind and initiate opening of silent chromatin regions. Pioneer factors subsequently regulate lineage-specific genes and enhancers and, thus, activate the zygotic genome after fertilization, guide cell fate transitions during development, and promote various forms of human cancers. As such, pioneer factors are useful in directed cell reprogramming. In this review, we define the structural and functional characteristics of pioneer factors, how they bind...
Source: Trends in Genetics : TIG - November 8, 2023 Category: Genetics & Stem Cells Authors: Amandine Barral Kenneth S Zaret Source Type: research
