A sea star is only a head
Trends Genet. 2024 Jan 31:S0168-9525(24)00008-8. doi: 10.1016/j.tig.2024.01.008. Online ahead of print.ABSTRACTWhere are the front and back ends in a sea star? Formery et al. recently tackled this long-standing mystery using state-of-the-art molecular tools, leading them to suggest that a sea star may be constructed from components that, in other animals, would constitute only the head.PMID:38302301 | DOI:10.1016/j.tig.2024.01.008 (Source: Trends in Genetics : TIG)
Source: Trends in Genetics : TIG - February 1, 2024 Category: Genetics & Stem Cells Authors: Andreas Hejnol Source Type: research
How intrinsically disordered proteins order plant gene silencing
Trends Genet. 2024 Jan 30:S0168-9525(23)00284-6. doi: 10.1016/j.tig.2023.12.009. Online ahead of print.ABSTRACTIntrinsically disordered proteins (IDPs) and proteins with intrinsically disordered regions (IDRs) possess low sequence complexity of amino acids and display non-globular tertiary structures. They can act as scaffolds, form regulatory hubs, or trigger biomolecular condensation to control diverse aspects of biology. Emerging evidence has recently implicated critical roles of IDPs and IDR-contained proteins in nuclear transcription and cytoplasmic post-transcriptional processes, among other molecular functions. We h...
Source: Trends in Genetics : TIG - January 31, 2024 Category: Genetics & Stem Cells Authors: Baoshuan Shang Changhao Li Xiuren Zhang Source Type: research
Duplicated gene networks promote 'hopeful' phenotypic variation
Trends Genet. 2024 Feb;40(2):109-111. doi: 10.1016/j.tig.2023.12.004. Epub 2024 Jan 24.ABSTRACTThe consequences of whole-genome duplication (WGD) remain elusive. A new study by Ebadi et al. simulating duplicated gene networks predicts that WGD immediately generates autopolyploids with extreme phenotypes and increases phenotypic variance. Such theoretical work calls for new experimental studies addressing to what extent WGD may be beneficial under environmental changes.PMID:38272738 | DOI:10.1016/j.tig.2023.12.004 (Source: Trends in Genetics : TIG)
Source: Trends in Genetics : TIG - January 25, 2024 Category: Genetics & Stem Cells Authors: Christian Parisod Source Type: research
Degradation and translation of maternal mRNA for embryogenesis
Trends Genet. 2024 Jan 22:S0168-9525(23)00283-4. doi: 10.1016/j.tig.2023.12.008. Online ahead of print.ABSTRACTMaternal mRNAs accumulate during egg growth and must be judiciously degraded or translated to ensure successful development of mammalian embryos. In this review we integrate recent investigations into pathways controlling rapid degradation of maternal mRNAs during the maternal-to-zygotic transition. Degradation is not indiscriminate, and some mRNAs are selectively protected and rapidly translated after fertilization for reprogramming the zygotic genome during early embryogenesis. Oocyte specific cofactors and path...
Source: Trends in Genetics : TIG - January 23, 2024 Category: Genetics & Stem Cells Authors: Guanghui Yang Qiliang Xin Jurrien Dean Source Type: research
Time will tell: comparing timescales to gain insight into transcriptional bursting
Trends Genet. 2024 Feb;40(2):160-174. doi: 10.1016/j.tig.2023.11.003. Epub 2024 Jan 12.ABSTRACTRecent imaging studies have captured the dynamics of regulatory events of transcription inside living cells. These events include transcription factor (TF) DNA binding, chromatin remodeling and modification, enhancer-promoter (E-P) proximity, cluster formation, and preinitiation complex (PIC) assembly. Together, these molecular events culminate in stochastic bursts of RNA synthesis, but their kinetic relationship remains largely unclear. In this review, we compare the timescales of upstream regulatory steps (input) with the kinet...
Source: Trends in Genetics : TIG - January 12, 2024 Category: Genetics & Stem Cells Authors: Joseph V W Meeussen Tineke L Lenstra Source Type: research
Gene regulation during meiosis
Trends Genet. 2024 Jan 3:S0168-9525(23)00265-2. doi: 10.1016/j.tig.2023.12.006. Online ahead of print.ABSTRACTMeiosis is essential for gamete production in all sexually reproducing organisms. It entails two successive cell divisions without DNA replication, producing haploid cells from diploid ones. This process involves complex morphological and molecular differentiation that varies across species and between sexes. Specialized genomic events like meiotic recombination and chromosome segregation are tightly regulated, including preparation for post-meiotic development. Research in model organisms, notably yeast, has shed ...
Source: Trends in Genetics : TIG - January 4, 2024 Category: Genetics & Stem Cells Authors: Jingyi Gao Yiwen Qin John C Schimenti Source Type: research
Gene regulation during meiosis
Trends Genet. 2024 Jan 3:S0168-9525(23)00265-2. doi: 10.1016/j.tig.2023.12.006. Online ahead of print.ABSTRACTMeiosis is essential for gamete production in all sexually reproducing organisms. It entails two successive cell divisions without DNA replication, producing haploid cells from diploid ones. This process involves complex morphological and molecular differentiation that varies across species and between sexes. Specialized genomic events like meiotic recombination and chromosome segregation are tightly regulated, including preparation for post-meiotic development. Research in model organisms, notably yeast, has shed ...
Source: Trends in Genetics : TIG - January 4, 2024 Category: Genetics & Stem Cells Authors: Jingyi Gao Yiwen Qin John C Schimenti Source Type: research
Gene regulation during meiosis
Trends Genet. 2024 Jan 3:S0168-9525(23)00265-2. doi: 10.1016/j.tig.2023.12.006. Online ahead of print.ABSTRACTMeiosis is essential for gamete production in all sexually reproducing organisms. It entails two successive cell divisions without DNA replication, producing haploid cells from diploid ones. This process involves complex morphological and molecular differentiation that varies across species and between sexes. Specialized genomic events like meiotic recombination and chromosome segregation are tightly regulated, including preparation for post-meiotic development. Research in model organisms, notably yeast, has shed ...
Source: Trends in Genetics : TIG - January 4, 2024 Category: Genetics & Stem Cells Authors: Jingyi Gao Yiwen Qin John C Schimenti Source Type: research
Gene regulation during meiosis
Trends Genet. 2024 Jan 3:S0168-9525(23)00265-2. doi: 10.1016/j.tig.2023.12.006. Online ahead of print.ABSTRACTMeiosis is essential for gamete production in all sexually reproducing organisms. It entails two successive cell divisions without DNA replication, producing haploid cells from diploid ones. This process involves complex morphological and molecular differentiation that varies across species and between sexes. Specialized genomic events like meiotic recombination and chromosome segregation are tightly regulated, including preparation for post-meiotic development. Research in model organisms, notably yeast, has shed ...
Source: Trends in Genetics : TIG - January 4, 2024 Category: Genetics & Stem Cells Authors: Jingyi Gao Yiwen Qin John C Schimenti Source Type: research
Gene regulation during meiosis
Trends Genet. 2024 Jan 3:S0168-9525(23)00265-2. doi: 10.1016/j.tig.2023.12.006. Online ahead of print.ABSTRACTMeiosis is essential for gamete production in all sexually reproducing organisms. It entails two successive cell divisions without DNA replication, producing haploid cells from diploid ones. This process involves complex morphological and molecular differentiation that varies across species and between sexes. Specialized genomic events like meiotic recombination and chromosome segregation are tightly regulated, including preparation for post-meiotic development. Research in model organisms, notably yeast, has shed ...
Source: Trends in Genetics : TIG - January 4, 2024 Category: Genetics & Stem Cells Authors: Jingyi Gao Yiwen Qin John C Schimenti Source Type: research
Uncovering dark matter in cancer by identifying epigenetic drivers
Trends Genet. 2024 Jan 2:S0168-9525(23)00264-0. doi: 10.1016/j.tig.2023.12.005. Online ahead of print.ABSTRACTThe complex relationship between chromatin accessibility, transcriptional regulation, and cancer transitions presents a daunting puzzle. Terekhanova et al. created a pan-cancer epigenetic and transcriptomic atlas at single-cell resolution, yielding important insights into the underlying chromatin architecture of cancer transitions and novel discoveries with the potential to advance precision medicine.PMID:38171966 | DOI:10.1016/j.tig.2023.12.005 (Source: Trends in Genetics : TIG)
Source: Trends in Genetics : TIG - January 3, 2024 Category: Genetics & Stem Cells Authors: Jun Zhong Laufey T Amundadottir Source Type: research
The genetic landscape of age-related hearing loss
Trends Genet. 2023 Dec 30:S0168-9525(23)00260-3. doi: 10.1016/j.tig.2023.12.001. Online ahead of print.ABSTRACTAge-related hearing loss (ARHL) is a prevalent concern in the elderly population. Recent genome-wide and phenome-wide association studies (GWASs and PheWASs) have delved into the identification of causative variants and the understanding of pleiotropy, highlighting the polygenic intricacies of this complex condition. While recent large-scale GWASs have pinpointed significant SNPs and risk variants associated with ARHL, the detailed mechanisms, encompassing both genetic and epigenetic modifications, remain to be fu...
Source: Trends in Genetics : TIG - December 31, 2023 Category: Genetics & Stem Cells Authors: Yuzuru Ninoyu Rick A Friedman Source Type: research
The genetic landscape of age-related hearing loss
Trends Genet. 2023 Dec 30:S0168-9525(23)00260-3. doi: 10.1016/j.tig.2023.12.001. Online ahead of print.ABSTRACTAge-related hearing loss (ARHL) is a prevalent concern in the elderly population. Recent genome-wide and phenome-wide association studies (GWASs and PheWASs) have delved into the identification of causative variants and the understanding of pleiotropy, highlighting the polygenic intricacies of this complex condition. While recent large-scale GWASs have pinpointed significant SNPs and risk variants associated with ARHL, the detailed mechanisms, encompassing both genetic and epigenetic modifications, remain to be fu...
Source: Trends in Genetics : TIG - December 31, 2023 Category: Genetics & Stem Cells Authors: Yuzuru Ninoyu Rick A Friedman Source Type: research
The genetic landscape of age-related hearing loss
Trends Genet. 2023 Dec 30:S0168-9525(23)00260-3. doi: 10.1016/j.tig.2023.12.001. Online ahead of print.ABSTRACTAge-related hearing loss (ARHL) is a prevalent concern in the elderly population. Recent genome-wide and phenome-wide association studies (GWASs and PheWASs) have delved into the identification of causative variants and the understanding of pleiotropy, highlighting the polygenic intricacies of this complex condition. While recent large-scale GWASs have pinpointed significant SNPs and risk variants associated with ARHL, the detailed mechanisms, encompassing both genetic and epigenetic modifications, remain to be fu...
Source: Trends in Genetics : TIG - December 31, 2023 Category: Genetics & Stem Cells Authors: Yuzuru Ninoyu Rick A Friedman Source Type: research
In search of critical dsRNA targets of ADAR1
Trends Genet. 2023 Dec 29:S0168-9525(23)00261-5. doi: 10.1016/j.tig.2023.12.002. Online ahead of print.ABSTRACTRecent studies have underscored the pivotal role of adenosine-to-inosine RNA editing, catalyzed by ADAR1, in suppressing innate immune interferon responses triggered by cellular double-stranded RNA (dsRNA). However, the specific ADAR1 editing targets crucial for this regulatory function remain elusive. We review analyses of transcriptome-wide ADAR1 editing patterns and their evolutionary dynamics, which offer valuable insights into this unresolved query. The growing appreciation of the significance of immunogenic ...
Source: Trends in Genetics : TIG - December 30, 2023 Category: Genetics & Stem Cells Authors: Erez Y Levanon Roni Cohen-Fultheim Eli Eisenberg Source Type: research
