Single-cell dissection of tumor microenvironmental response and resistance to cancer therapy
Trends Genet. 2023 Aug 30:S0168-9525(23)00163-4. doi: 10.1016/j.tig.2023.07.005. Online ahead of print.ABSTRACTCancer treatment strategies have evolved significantly over the years, with chemotherapy, targeted therapy, and immunotherapy as major pillars. Each modality leads to unique treatment outcomes by interacting with the tumor microenvironment (TME), which imposes a fundamental selective pressure on cancer progression. The advent of single-cell profiling technologies has revolutionized our understanding of the intricate and heterogeneous nature of the TME at an unprecedented resolution. This review delves into the com...
Source: Trends in Genetics : TIG - September 1, 2023 Category: Genetics & Stem Cells Authors: Yikai Luo Han Liang Source Type: research
Single-cell dissection of tumor microenvironmental response and resistance to cancer therapy
Trends Genet. 2023 Aug 30:S0168-9525(23)00163-4. doi: 10.1016/j.tig.2023.07.005. Online ahead of print.ABSTRACTCancer treatment strategies have evolved significantly over the years, with chemotherapy, targeted therapy, and immunotherapy as major pillars. Each modality leads to unique treatment outcomes by interacting with the tumor microenvironment (TME), which imposes a fundamental selective pressure on cancer progression. The advent of single-cell profiling technologies has revolutionized our understanding of the intricate and heterogeneous nature of the TME at an unprecedented resolution. This review delves into the com...
Source: Trends in Genetics : TIG - September 1, 2023 Category: Genetics & Stem Cells Authors: Yikai Luo Han Liang Source Type: research
Conservation macrogenetics: harnessing genetic data to meet conservation commitments
Trends Genet. 2023 Aug 28:S0168-9525(23)00181-6. doi: 10.1016/j.tig.2023.08.002. Online ahead of print.ABSTRACTGenetic biodiversity is rapidly gaining attention in global conservation policy. However, for almost all species, conservation relevant, population-level genetic data are lacking, limiting the extent to which genetic diversity can be used for conservation policy and decision-making. Macrogenetics is an emerging discipline that explores the patterns and processes underlying population genetic composition at broad taxonomic and spatial scales by aggregating and reanalyzing thousands of published genetic datasets. He...
Source: Trends in Genetics : TIG - August 30, 2023 Category: Genetics & Stem Cells Authors: Chlo é Schmidt Sean Hoban Walter Jetz Source Type: research
Conservation macrogenetics: harnessing genetic data to meet conservation commitments
Trends Genet. 2023 Aug 28:S0168-9525(23)00181-6. doi: 10.1016/j.tig.2023.08.002. Online ahead of print.ABSTRACTGenetic biodiversity is rapidly gaining attention in global conservation policy. However, for almost all species, conservation relevant, population-level genetic data are lacking, limiting the extent to which genetic diversity can be used for conservation policy and decision-making. Macrogenetics is an emerging discipline that explores the patterns and processes underlying population genetic composition at broad taxonomic and spatial scales by aggregating and reanalyzing thousands of published genetic datasets. He...
Source: Trends in Genetics : TIG - August 30, 2023 Category: Genetics & Stem Cells Authors: Chlo é Schmidt Sean Hoban Walter Jetz Source Type: research
WRKY transcription factors in plant defense
Trends Genet. 2023 Aug 25:S0168-9525(23)00159-2. doi: 10.1016/j.tig.2023.07.001. Online ahead of print.ABSTRACTEnvironmental stressors caused by climate change are fundamental barriers to agricultural sustainability. Enhancing the stress resilience of crops is a key strategy in achieving global food security. Plants perceive adverse environmental conditions and initiate signaling pathways to activate precise responses that contribute to their survival. WRKY transcription factors (TFs) are essential players in several signaling cascades and regulatory networks that have crucial implications for defense responses in plants. ...
Source: Trends in Genetics : TIG - August 26, 2023 Category: Genetics & Stem Cells Authors: Talha Javed San-Ji Gao Source Type: research
WRKY transcription factors in plant defense
Trends Genet. 2023 Aug 25:S0168-9525(23)00159-2. doi: 10.1016/j.tig.2023.07.001. Online ahead of print.ABSTRACTEnvironmental stressors caused by climate change are fundamental barriers to agricultural sustainability. Enhancing the stress resilience of crops is a key strategy in achieving global food security. Plants perceive adverse environmental conditions and initiate signaling pathways to activate precise responses that contribute to their survival. WRKY transcription factors (TFs) are essential players in several signaling cascades and regulatory networks that have crucial implications for defense responses in plants. ...
Source: Trends in Genetics : TIG - August 26, 2023 Category: Genetics & Stem Cells Authors: Talha Javed San-Ji Gao Source Type: research
WRKY transcription factors in plant defense
Trends Genet. 2023 Aug 25:S0168-9525(23)00159-2. doi: 10.1016/j.tig.2023.07.001. Online ahead of print.ABSTRACTEnvironmental stressors caused by climate change are fundamental barriers to agricultural sustainability. Enhancing the stress resilience of crops is a key strategy in achieving global food security. Plants perceive adverse environmental conditions and initiate signaling pathways to activate precise responses that contribute to their survival. WRKY transcription factors (TFs) are essential players in several signaling cascades and regulatory networks that have crucial implications for defense responses in plants. ...
Source: Trends in Genetics : TIG - August 26, 2023 Category: Genetics & Stem Cells Authors: Talha Javed San-Ji Gao Source Type: research
WRKY transcription factors in plant defense
Trends Genet. 2023 Aug 25:S0168-9525(23)00159-2. doi: 10.1016/j.tig.2023.07.001. Online ahead of print.ABSTRACTEnvironmental stressors caused by climate change are fundamental barriers to agricultural sustainability. Enhancing the stress resilience of crops is a key strategy in achieving global food security. Plants perceive adverse environmental conditions and initiate signaling pathways to activate precise responses that contribute to their survival. WRKY transcription factors (TFs) are essential players in several signaling cascades and regulatory networks that have crucial implications for defense responses in plants. ...
Source: Trends in Genetics : TIG - August 26, 2023 Category: Genetics & Stem Cells Authors: Talha Javed San-Ji Gao Source Type: research
Discovering genes that affect cognitive ability
Trends Genet. 2023 Aug 16:S0168-9525(23)00167-1. doi: 10.1016/j.tig.2023.08.001. Online ahead of print.ABSTRACTTwin and genomic studies indicate that genes play an important role in the development of cognitive ability. However, data limitations have made it difficult to pinpoint specific genes with a large impact. By examining the full gene sequences of >300 000 individuals, Chen et al. find eight such genes.PMID:37596117 | DOI:10.1016/j.tig.2023.08.001 (Source: Trends in Genetics : TIG)
Source: Trends in Genetics : TIG - August 18, 2023 Category: Genetics & Stem Cells Authors: Alexander Strudwick Young Hilary C Martin Source Type: research
Discovering genes that affect cognitive ability
Trends Genet. 2023 Aug 16:S0168-9525(23)00167-1. doi: 10.1016/j.tig.2023.08.001. Online ahead of print.ABSTRACTTwin and genomic studies indicate that genes play an important role in the development of cognitive ability. However, data limitations have made it difficult to pinpoint specific genes with a large impact. By examining the full gene sequences of >300 000 individuals, Chen et al. find eight such genes.PMID:37596117 | DOI:10.1016/j.tig.2023.08.001 (Source: Trends in Genetics : TIG)
Source: Trends in Genetics : TIG - August 18, 2023 Category: Genetics & Stem Cells Authors: Alexander Strudwick Young Hilary C Martin Source Type: research
Discovering genes that affect cognitive ability
Trends Genet. 2023 Aug 16:S0168-9525(23)00167-1. doi: 10.1016/j.tig.2023.08.001. Online ahead of print.ABSTRACTTwin and genomic studies indicate that genes play an important role in the development of cognitive ability. However, data limitations have made it difficult to pinpoint specific genes with a large impact. By examining the full gene sequences of >300 000 individuals, Chen et al. find eight such genes.PMID:37596117 | DOI:10.1016/j.tig.2023.08.001 (Source: Trends in Genetics : TIG)
Source: Trends in Genetics : TIG - August 18, 2023 Category: Genetics & Stem Cells Authors: Alexander Strudwick Young Hilary C Martin Source Type: research
Discovering genes that affect cognitive ability
Trends Genet. 2023 Aug 16:S0168-9525(23)00167-1. doi: 10.1016/j.tig.2023.08.001. Online ahead of print.ABSTRACTTwin and genomic studies indicate that genes play an important role in the development of cognitive ability. However, data limitations have made it difficult to pinpoint specific genes with a large impact. By examining the full gene sequences of >300 000 individuals, Chen et al. find eight such genes.PMID:37596117 | DOI:10.1016/j.tig.2023.08.001 (Source: Trends in Genetics : TIG)
Source: Trends in Genetics : TIG - August 18, 2023 Category: Genetics & Stem Cells Authors: Alexander Strudwick Young Hilary C Martin Source Type: research
Discovering genes that affect cognitive ability
Trends Genet. 2023 Aug 16:S0168-9525(23)00167-1. doi: 10.1016/j.tig.2023.08.001. Online ahead of print.ABSTRACTTwin and genomic studies indicate that genes play an important role in the development of cognitive ability. However, data limitations have made it difficult to pinpoint specific genes with a large impact. By examining the full gene sequences of >300 000 individuals, Chen et al. find eight such genes.PMID:37596117 | DOI:10.1016/j.tig.2023.08.001 (Source: Trends in Genetics : TIG)
Source: Trends in Genetics : TIG - August 18, 2023 Category: Genetics & Stem Cells Authors: Alexander Strudwick Young Hilary C Martin Source Type: research
Discovering genes that affect cognitive ability
Trends Genet. 2023 Aug 16:S0168-9525(23)00167-1. doi: 10.1016/j.tig.2023.08.001. Online ahead of print.ABSTRACTTwin and genomic studies indicate that genes play an important role in the development of cognitive ability. However, data limitations have made it difficult to pinpoint specific genes with a large impact. By examining the full gene sequences of >300 000 individuals, Chen et al. find eight such genes.PMID:37596117 | DOI:10.1016/j.tig.2023.08.001 (Source: Trends in Genetics : TIG)
Source: Trends in Genetics : TIG - August 18, 2023 Category: Genetics & Stem Cells Authors: Alexander Strudwick Young Hilary C Martin Source Type: research
From genome size to trait evolution during angiosperm radiation
Trends Genet. 2023 Aug 14:S0168-9525(23)00164-6. doi: 10.1016/j.tig.2023.07.006. Online ahead of print.ABSTRACTAngiosperm diversity arises from trait flexibility and repeated evolutionary radiations, but the role of genomic characters in these radiations remains unclear. In this opinion article, we discuss how genome size can influence angiosperm diversification via its intricate link with cell size, tissue packing, and physiological processes which, in turn, influence the macroevolution of functional traits. We propose that integrating genome size, functional traits, and phylogenetic data across a wide range of lineages a...
Source: Trends in Genetics : TIG - August 15, 2023 Category: Genetics & Stem Cells Authors: Sreetama Bhadra Ilia J Leitch Renske E Onstein Source Type: research
