Noncoding snoRNA host genes are a distinct subclass of long noncoding RNAs
Trends Genet. 2023 Sep 30:S0168-9525(23)00218-4. doi: 10.1016/j.tig.2023.09.001. Online ahead of print.ABSTRACTMammalian genomes are pervasively transcribed into different noncoding (nc)RNA classes, each one with its own hallmarks and exceptions. Some of them are nested into each other, such as host genes for small nucleolar RNAs (snoRNAs), which were long believed to simply act as molecular containers strictly facilitating snoRNA biogenesis. However, recent findings show that noncoding snoRNA host genes (ncSNHGs) display features different from those of 'regular' long ncRNAs (lncRNAs) and, more importantly, they can exert...
Source: Trends in Genetics : TIG - October 2, 2023 Category: Genetics & Stem Cells Authors: Alan Monziani Igor Ulitsky Source Type: research
Noncoding snoRNA host genes are a distinct subclass of long noncoding RNAs
Trends Genet. 2023 Sep 30:S0168-9525(23)00218-4. doi: 10.1016/j.tig.2023.09.001. Online ahead of print.ABSTRACTMammalian genomes are pervasively transcribed into different noncoding (nc)RNA classes, each one with its own hallmarks and exceptions. Some of them are nested into each other, such as host genes for small nucleolar RNAs (snoRNAs), which were long believed to simply act as molecular containers strictly facilitating snoRNA biogenesis. However, recent findings show that noncoding snoRNA host genes (ncSNHGs) display features different from those of 'regular' long ncRNAs (lncRNAs) and, more importantly, they can exert...
Source: Trends in Genetics : TIG - October 2, 2023 Category: Genetics & Stem Cells Authors: Alan Monziani Igor Ulitsky Source Type: research
Aneuploidy in human cancer: new tools and perspectives
Trends Genet. 2023 Sep 29:S0168-9525(23)00219-6. doi: 10.1016/j.tig.2023.09.002. Online ahead of print.ABSTRACTChromosome copy number imbalances, otherwise known as aneuploidies, are a common but poorly understood feature of cancer. Here, we describe recent advances in both detecting and manipulating aneuploidies that have greatly advanced our ability to study their role in tumorigenesis. In particular, new clustered regularly interspaced short palindromic repeats (CRISPR)-based techniques have been developed that allow the creation of isogenic cell lines with specific chromosomal changes, thereby facilitating experiments ...
Source: Trends in Genetics : TIG - October 1, 2023 Category: Genetics & Stem Cells Authors: Asad A Lakhani Sarah L Thompson Jason M Sheltzer Source Type: research
Aneuploidy in human cancer: new tools and perspectives
Trends Genet. 2023 Sep 29:S0168-9525(23)00219-6. doi: 10.1016/j.tig.2023.09.002. Online ahead of print.ABSTRACTChromosome copy number imbalances, otherwise known as aneuploidies, are a common but poorly understood feature of cancer. Here, we describe recent advances in both detecting and manipulating aneuploidies that have greatly advanced our ability to study their role in tumorigenesis. In particular, new clustered regularly interspaced short palindromic repeats (CRISPR)-based techniques have been developed that allow the creation of isogenic cell lines with specific chromosomal changes, thereby facilitating experiments ...
Source: Trends in Genetics : TIG - October 1, 2023 Category: Genetics & Stem Cells Authors: Asad A Lakhani Sarah L Thompson Jason M Sheltzer Source Type: research
An updated view of the kinetochore architecture
Trends Genet. 2023 Sep 27:S0168-9525(23)00220-2. doi: 10.1016/j.tig.2023.09.003. Online ahead of print.ABSTRACTThe kinetochore is a supramolecular complex that facilitates faithful chromosome segregation by bridging the centromere and spindle microtubules. Recent functional and structural studies on the inner kinetochore subcomplex, constitutive centromere-associated network (CCAN) have updated our understanding of kinetochore architecture. While the CCAN core establishes a stable interface with centromeric chromatin, CCAN organization is dynamically altered and coupled with cell cycle progression. Furthermore, the CCAN co...
Source: Trends in Genetics : TIG - September 29, 2023 Category: Genetics & Stem Cells Authors: Mariko Ariyoshi Tatsuo Fukagawa Source Type: research
An updated view of the kinetochore architecture
Trends Genet. 2023 Sep 27:S0168-9525(23)00220-2. doi: 10.1016/j.tig.2023.09.003. Online ahead of print.ABSTRACTThe kinetochore is a supramolecular complex that facilitates faithful chromosome segregation by bridging the centromere and spindle microtubules. Recent functional and structural studies on the inner kinetochore subcomplex, constitutive centromere-associated network (CCAN) have updated our understanding of kinetochore architecture. While the CCAN core establishes a stable interface with centromeric chromatin, CCAN organization is dynamically altered and coupled with cell cycle progression. Furthermore, the CCAN co...
Source: Trends in Genetics : TIG - September 29, 2023 Category: Genetics & Stem Cells Authors: Mariko Ariyoshi Tatsuo Fukagawa Source Type: research
Protecting axons in grandchildren
Trends Genet. 2023 Sep 22:S0168-9525(23)00222-6. doi: 10.1016/j.tig.2023.09.005. Online ahead of print.ABSTRACTPrenatal exposure to environmental agents can influence the fitness of not only the fetus, but also subsequent generations. In a recent study, Wang et al. demonstrated that feeding ursolic acid (UA), a plant-derived compound, to Caenorhabditis elegans mothers during their reproductive period prevented neurodegeneration in not only their offspring, but also the F2 progeny.PMID:37743186 | DOI:10.1016/j.tig.2023.09.005 (Source: Trends in Genetics : TIG)
Source: Trends in Genetics : TIG - September 24, 2023 Category: Genetics & Stem Cells Authors: Surojit Sural Source Type: research
Protecting axons in grandchildren
Trends Genet. 2023 Sep 22:S0168-9525(23)00222-6. doi: 10.1016/j.tig.2023.09.005. Online ahead of print.ABSTRACTPrenatal exposure to environmental agents can influence the fitness of not only the fetus, but also subsequent generations. In a recent study, Wang et al. demonstrated that feeding ursolic acid (UA), a plant-derived compound, to Caenorhabditis elegans mothers during their reproductive period prevented neurodegeneration in not only their offspring, but also the F2 progeny.PMID:37743186 | DOI:10.1016/j.tig.2023.09.005 (Source: Trends in Genetics : TIG)
Source: Trends in Genetics : TIG - September 24, 2023 Category: Genetics & Stem Cells Authors: Surojit Sural Source Type: research
Protecting axons in grandchildren
Trends Genet. 2023 Sep 22:S0168-9525(23)00222-6. doi: 10.1016/j.tig.2023.09.005. Online ahead of print.ABSTRACTPrenatal exposure to environmental agents can influence the fitness of not only the fetus, but also subsequent generations. In a recent study, Wang et al. demonstrated that feeding ursolic acid (UA), a plant-derived compound, to Caenorhabditis elegans mothers during their reproductive period prevented neurodegeneration in not only their offspring, but also the F2 progeny.PMID:37743186 | DOI:10.1016/j.tig.2023.09.005 (Source: Trends in Genetics : TIG)
Source: Trends in Genetics : TIG - September 24, 2023 Category: Genetics & Stem Cells Authors: Surojit Sural Source Type: research
Protecting axons in grandchildren
Trends Genet. 2023 Sep 22:S0168-9525(23)00222-6. doi: 10.1016/j.tig.2023.09.005. Online ahead of print.ABSTRACTPrenatal exposure to environmental agents can influence the fitness of not only the fetus, but also subsequent generations. In a recent study, Wang et al. demonstrated that feeding ursolic acid (UA), a plant-derived compound, to Caenorhabditis elegans mothers during their reproductive period prevented neurodegeneration in not only their offspring, but also the F2 progeny.PMID:37743186 | DOI:10.1016/j.tig.2023.09.005 (Source: Trends in Genetics : TIG)
Source: Trends in Genetics : TIG - September 24, 2023 Category: Genetics & Stem Cells Authors: Surojit Sural Source Type: research
Protecting axons in grandchildren
Trends Genet. 2023 Sep 22:S0168-9525(23)00222-6. doi: 10.1016/j.tig.2023.09.005. Online ahead of print.ABSTRACTPrenatal exposure to environmental agents can influence the fitness of not only the fetus, but also subsequent generations. In a recent study, Wang et al. demonstrated that feeding ursolic acid (UA), a plant-derived compound, to Caenorhabditis elegans mothers during their reproductive period prevented neurodegeneration in not only their offspring, but also the F2 progeny.PMID:37743186 | DOI:10.1016/j.tig.2023.09.005 (Source: Trends in Genetics : TIG)
Source: Trends in Genetics : TIG - September 24, 2023 Category: Genetics & Stem Cells Authors: Surojit Sural Source Type: research
Take a walk on the KRAB side
Trends Genet. 2023 Sep 14:S0168-9525(23)00185-3. doi: 10.1016/j.tig.2023.08.003. Online ahead of print.ABSTRACTCanonical Krüppel-associated box (KRAB)-containing zinc finger proteins (KZFPs) act as major repressors of transposable elements (TEs) via the KRAB-mediated recruitment of the heterochromatin scaffold KRAB-associated protein (KAP)1. KZFP genes emerged some 420 million years ago in the last common ancestor of coelacanth, lungfish, and tetrapods, and dramatically expanded to give rise to lineage-specific repertoires in contemporary species paralleling their TE load and turnover. However, the KRAB domain displays se...
Source: Trends in Genetics : TIG - September 16, 2023 Category: Genetics & Stem Cells Authors: Olga Rosspopoff Didier Trono Source Type: research
Take a walk on the KRAB side
Trends Genet. 2023 Sep 14:S0168-9525(23)00185-3. doi: 10.1016/j.tig.2023.08.003. Online ahead of print.ABSTRACTCanonical Krüppel-associated box (KRAB)-containing zinc finger proteins (KZFPs) act as major repressors of transposable elements (TEs) via the KRAB-mediated recruitment of the heterochromatin scaffold KRAB-associated protein (KAP)1. KZFP genes emerged some 420 million years ago in the last common ancestor of coelacanth, lungfish, and tetrapods, and dramatically expanded to give rise to lineage-specific repertoires in contemporary species paralleling their TE load and turnover. However, the KRAB domain displays se...
Source: Trends in Genetics : TIG - September 16, 2023 Category: Genetics & Stem Cells Authors: Olga Rosspopoff Didier Trono Source Type: research
Take a walk on the KRAB side
Trends Genet. 2023 Sep 14:S0168-9525(23)00185-3. doi: 10.1016/j.tig.2023.08.003. Online ahead of print.ABSTRACTCanonical Krüppel-associated box (KRAB)-containing zinc finger proteins (KZFPs) act as major repressors of transposable elements (TEs) via the KRAB-mediated recruitment of the heterochromatin scaffold KRAB-associated protein (KAP)1. KZFP genes emerged some 420 million years ago in the last common ancestor of coelacanth, lungfish, and tetrapods, and dramatically expanded to give rise to lineage-specific repertoires in contemporary species paralleling their TE load and turnover. However, the KRAB domain displays se...
Source: Trends in Genetics : TIG - September 16, 2023 Category: Genetics & Stem Cells Authors: Olga Rosspopoff Didier Trono Source Type: research
Take a walk on the KRAB side
Trends Genet. 2023 Sep 14:S0168-9525(23)00185-3. doi: 10.1016/j.tig.2023.08.003. Online ahead of print.ABSTRACTCanonical Krüppel-associated box (KRAB)-containing zinc finger proteins (KZFPs) act as major repressors of transposable elements (TEs) via the KRAB-mediated recruitment of the heterochromatin scaffold KRAB-associated protein (KAP)1. KZFP genes emerged some 420 million years ago in the last common ancestor of coelacanth, lungfish, and tetrapods, and dramatically expanded to give rise to lineage-specific repertoires in contemporary species paralleling their TE load and turnover. However, the KRAB domain displays se...
Source: Trends in Genetics : TIG - September 16, 2023 Category: Genetics & Stem Cells Authors: Olga Rosspopoff Didier Trono Source Type: research
