Genetic distance informs polygenic score predictive accuracy
Trends Genet. 2023 Jul 29:S0168-9525(23)00160-9. doi: 10.1016/j.tig.2023.07.002. Online ahead of print.ABSTRACTPolygenic scores (PGSs) aggregate the effects of variants across the genome to estimate genetic liability, but have lower performance in external study populations. A new study by Ding et al. has applied a novel framework to estimate the individual-level predictive accuracy of PGSs, and demonstrates that performance reduction occurs linearly with genetic distance.PMID:37524625 | DOI:10.1016/j.tig.2023.07.002 (Source: Trends in Genetics : TIG)
Source: Trends in Genetics : TIG - July 31, 2023 Category: Genetics & Stem Cells Authors: Genevieve L Wojcik Source Type: research
Leveraging microbiome information for animal genetic improvement
Trends Genet. 2023 Jul 27:S0168-9525(23)00162-2. doi: 10.1016/j.tig.2023.07.004. Online ahead of print.ABSTRACTThere is growing evidence that the microbiome influences host phenotypic variation. Incorporating information about the holobiont - the host and its microbiome - into genomic prediction models may accelerate genetic improvements in farmed animal populations. Importantly, these models must account for the indirect effects of the host genome on microbiome-mediated phenotypes.PMID:37516623 | DOI:10.1016/j.tig.2023.07.004 (Source: Trends in Genetics : TIG)
Source: Trends in Genetics : TIG - July 29, 2023 Category: Genetics & Stem Cells Authors: Lucas Venegas Paulina L ópez Nicolas Derome Jos é M Yáñez Source Type: research
Leveraging microbiome information for animal genetic improvement
Trends Genet. 2023 Jul 27:S0168-9525(23)00162-2. doi: 10.1016/j.tig.2023.07.004. Online ahead of print.ABSTRACTThere is growing evidence that the microbiome influences host phenotypic variation. Incorporating information about the holobiont - the host and its microbiome - into genomic prediction models may accelerate genetic improvements in farmed animal populations. Importantly, these models must account for the indirect effects of the host genome on microbiome-mediated phenotypes.PMID:37516623 | DOI:10.1016/j.tig.2023.07.004 (Source: Trends in Genetics : TIG)
Source: Trends in Genetics : TIG - July 29, 2023 Category: Genetics & Stem Cells Authors: Lucas Venegas Paulina L ópez Nicolas Derome Jos é M Yáñez Source Type: research
Molecular bases of comorbidities: present and future perspectives
Trends Genet. 2023 Jul 21:S0168-9525(23)00134-8. doi: 10.1016/j.tig.2023.06.003. Online ahead of print.ABSTRACTCo-occurrence of diseases decreases patient quality of life, complicates treatment choices, and increases mortality. Analyses of electronic health records present a complex scenario of comorbidity relationships that vary by age, sex, and cohort under study. The study of similarities between diseases using 'omics data, such as genes altered in diseases, gene expression, proteome, and microbiome, are fundamental to uncovering the origin of, and potential treatment for, comorbidities. Recent studies have produced a f...
Source: Trends in Genetics : TIG - July 23, 2023 Category: Genetics & Stem Cells Authors: Jon S ánchez-Valle Alfonso Valencia Source Type: research
Molecular bases of comorbidities: present and future perspectives
Trends Genet. 2023 Jul 21:S0168-9525(23)00134-8. doi: 10.1016/j.tig.2023.06.003. Online ahead of print.ABSTRACTCo-occurrence of diseases decreases patient quality of life, complicates treatment choices, and increases mortality. Analyses of electronic health records present a complex scenario of comorbidity relationships that vary by age, sex, and cohort under study. The study of similarities between diseases using 'omics data, such as genes altered in diseases, gene expression, proteome, and microbiome, are fundamental to uncovering the origin of, and potential treatment for, comorbidities. Recent studies have produced a f...
Source: Trends in Genetics : TIG - July 23, 2023 Category: Genetics & Stem Cells Authors: Jon S ánchez-Valle Alfonso Valencia Source Type: research
Molecular bases of comorbidities: present and future perspectives
Trends Genet. 2023 Jul 21:S0168-9525(23)00134-8. doi: 10.1016/j.tig.2023.06.003. Online ahead of print.ABSTRACTCo-occurrence of diseases decreases patient quality of life, complicates treatment choices, and increases mortality. Analyses of electronic health records present a complex scenario of comorbidity relationships that vary by age, sex, and cohort under study. The study of similarities between diseases using 'omics data, such as genes altered in diseases, gene expression, proteome, and microbiome, are fundamental to uncovering the origin of, and potential treatment for, comorbidities. Recent studies have produced a f...
Source: Trends in Genetics : TIG - July 23, 2023 Category: Genetics & Stem Cells Authors: Jon S ánchez-Valle Alfonso Valencia Source Type: research
Molecular bases of comorbidities: present and future perspectives
Trends Genet. 2023 Jul 21:S0168-9525(23)00134-8. doi: 10.1016/j.tig.2023.06.003. Online ahead of print.ABSTRACTCo-occurrence of diseases decreases patient quality of life, complicates treatment choices, and increases mortality. Analyses of electronic health records present a complex scenario of comorbidity relationships that vary by age, sex, and cohort under study. The study of similarities between diseases using 'omics data, such as genes altered in diseases, gene expression, proteome, and microbiome, are fundamental to uncovering the origin of, and potential treatment for, comorbidities. Recent studies have produced a f...
Source: Trends in Genetics : TIG - July 23, 2023 Category: Genetics & Stem Cells Authors: Jon S ánchez-Valle Alfonso Valencia Source Type: research
Molecular bases of comorbidities: present and future perspectives
Trends Genet. 2023 Jul 21:S0168-9525(23)00134-8. doi: 10.1016/j.tig.2023.06.003. Online ahead of print.ABSTRACTCo-occurrence of diseases decreases patient quality of life, complicates treatment choices, and increases mortality. Analyses of electronic health records present a complex scenario of comorbidity relationships that vary by age, sex, and cohort under study. The study of similarities between diseases using 'omics data, such as genes altered in diseases, gene expression, proteome, and microbiome, are fundamental to uncovering the origin of, and potential treatment for, comorbidities. Recent studies have produced a f...
Source: Trends in Genetics : TIG - July 23, 2023 Category: Genetics & Stem Cells Authors: Jon S ánchez-Valle Alfonso Valencia Source Type: research
Molecular bases of comorbidities: present and future perspectives
Trends Genet. 2023 Jul 21:S0168-9525(23)00134-8. doi: 10.1016/j.tig.2023.06.003. Online ahead of print.ABSTRACTCo-occurrence of diseases decreases patient quality of life, complicates treatment choices, and increases mortality. Analyses of electronic health records present a complex scenario of comorbidity relationships that vary by age, sex, and cohort under study. The study of similarities between diseases using 'omics data, such as genes altered in diseases, gene expression, proteome, and microbiome, are fundamental to uncovering the origin of, and potential treatment for, comorbidities. Recent studies have produced a f...
Source: Trends in Genetics : TIG - July 23, 2023 Category: Genetics & Stem Cells Authors: Jon S ánchez-Valle Alfonso Valencia Source Type: research
A prime example of precisely delivered DNA
Trends Genet. 2023 Jul 20:S0168-9525(23)00158-0. doi: 10.1016/j.tig.2023.06.012. Online ahead of print.ABSTRACTIncorporating large fragments of DNA into specific genome positions is an inefficient process even when using the most cutting-edge genome-editing tools. Sun et al. recently described the prime editing-mediated recombination of opportune targets (PrimeRoot) method, which precisely and efficiently integrates large fragments of DNA into plant genomes and has enormous potential in research and agriculture.PMID:37481441 | DOI:10.1016/j.tig.2023.06.012 (Source: Trends in Genetics : TIG)
Source: Trends in Genetics : TIG - July 22, 2023 Category: Genetics & Stem Cells Authors: Muhammad Arslan Mahmood Julian R Greenwood Source Type: research
Insights into Spt6: a histone chaperone that functions in transcription, DNA replication, and genome stability
Trends Genet. 2023 Jul 20:S0168-9525(23)00152-X. doi: 10.1016/j.tig.2023.06.008. Online ahead of print.ABSTRACTTranscription elongation requires elaborate coordination between the transcriptional machinery and chromatin regulatory factors to successfully produce RNA while preserving the epigenetic landscape. Recent structural and genomic studies have highlighted that suppressor of Ty 6 (Spt6), a conserved histone chaperone and transcription elongation factor, sits at the crux of the transcription elongation process. Other recent studies have revealed that Spt6 also promotes DNA replication and genome integrity. Here, we re...
Source: Trends in Genetics : TIG - July 22, 2023 Category: Genetics & Stem Cells Authors: Catherine L W Miller James L Warner Fred Winston Source Type: research
CRISPR enables heritable genome editing in planta
Trends Genet. 2023 Jul 8:S0168-9525(23)00155-5. doi: 10.1016/j.tig.2023.06.009. Online ahead of print.ABSTRACTRecent exciting developments in clustered regularly interspaced short palindromic repeats (CRISPR)-based genome editing showcase its potential to rapidly and efficiently edit genomes in planta, eliminating long processes of tissue culture and extensive breeding for crop improvement. These new methods offer heritable transgene-free edits in one generation, making them an attractive option for improving commercially important crops.PMID:37429772 | DOI:10.1016/j.tig.2023.06.009 (Source: Trends in Genetics : TIG)
Source: Trends in Genetics : TIG - July 10, 2023 Category: Genetics & Stem Cells Authors: Tofazzal Islam Shamfin Hossain Kasfy Source Type: research
CRISPR enables heritable genome editing in planta
Trends Genet. 2023 Jul 8:S0168-9525(23)00155-5. doi: 10.1016/j.tig.2023.06.009. Online ahead of print.ABSTRACTRecent exciting developments in clustered regularly interspaced short palindromic repeats (CRISPR)-based genome editing showcase its potential to rapidly and efficiently edit genomes in planta, eliminating long processes of tissue culture and extensive breeding for crop improvement. These new methods offer heritable transgene-free edits in one generation, making them an attractive option for improving commercially important crops.PMID:37429772 | DOI:10.1016/j.tig.2023.06.009 (Source: Trends in Genetics : TIG)
Source: Trends in Genetics : TIG - July 10, 2023 Category: Genetics & Stem Cells Authors: Tofazzal Islam Shamfin Hossain Kasfy Source Type: research
CRISPR enables heritable genome editing in planta
Trends Genet. 2023 Jul 8:S0168-9525(23)00155-5. doi: 10.1016/j.tig.2023.06.009. Online ahead of print.ABSTRACTRecent exciting developments in clustered regularly interspaced short palindromic repeats (CRISPR)-based genome editing showcase its potential to rapidly and efficiently edit genomes in planta, eliminating long processes of tissue culture and extensive breeding for crop improvement. These new methods offer heritable transgene-free edits in one generation, making them an attractive option for improving commercially important crops.PMID:37429772 | DOI:10.1016/j.tig.2023.06.009 (Source: Trends in Genetics : TIG)
Source: Trends in Genetics : TIG - July 10, 2023 Category: Genetics & Stem Cells Authors: Tofazzal Islam Shamfin Hossain Kasfy Source Type: research
CRISPR enables heritable genome editing in planta
Trends Genet. 2023 Jul 8:S0168-9525(23)00155-5. doi: 10.1016/j.tig.2023.06.009. Online ahead of print.ABSTRACTRecent exciting developments in clustered regularly interspaced short palindromic repeats (CRISPR)-based genome editing showcase its potential to rapidly and efficiently edit genomes in planta, eliminating long processes of tissue culture and extensive breeding for crop improvement. These new methods offer heritable transgene-free edits in one generation, making them an attractive option for improving commercially important crops.PMID:37429772 | DOI:10.1016/j.tig.2023.06.009 (Source: Trends in Genetics : TIG)
Source: Trends in Genetics : TIG - July 10, 2023 Category: Genetics & Stem Cells Authors: Tofazzal Islam Shamfin Hossain Kasfy Source Type: research
