CRISPR enables heritable genome editing in planta
Trends Genet. 2023 Jul 8:S0168-9525(23)00155-5. doi: 10.1016/j.tig.2023.06.009. Online ahead of print.ABSTRACTRecent exciting developments in clustered regularly interspaced short palindromic repeats (CRISPR)-based genome editing showcase its potential to rapidly and efficiently edit genomes in planta, eliminating long processes of tissue culture and extensive breeding for crop improvement. These new methods offer heritable transgene-free edits in one generation, making them an attractive option for improving commercially important crops.PMID:37429772 | DOI:10.1016/j.tig.2023.06.009 (Source: Trends in Genetics : TIG)
Source: Trends in Genetics : TIG - July 10, 2023 Category: Genetics & Stem Cells Authors: Tofazzal Islam Shamfin Hossain Kasfy Source Type: research
CRISPR enables heritable genome editing in planta
Trends Genet. 2023 Jul 8:S0168-9525(23)00155-5. doi: 10.1016/j.tig.2023.06.009. Online ahead of print.ABSTRACTRecent exciting developments in clustered regularly interspaced short palindromic repeats (CRISPR)-based genome editing showcase its potential to rapidly and efficiently edit genomes in planta, eliminating long processes of tissue culture and extensive breeding for crop improvement. These new methods offer heritable transgene-free edits in one generation, making them an attractive option for improving commercially important crops.PMID:37429772 | DOI:10.1016/j.tig.2023.06.009 (Source: Trends in Genetics : TIG)
Source: Trends in Genetics : TIG - July 10, 2023 Category: Genetics & Stem Cells Authors: Tofazzal Islam Shamfin Hossain Kasfy Source Type: research
CRISPR enables heritable genome editing in planta
Trends Genet. 2023 Jul 8:S0168-9525(23)00155-5. doi: 10.1016/j.tig.2023.06.009. Online ahead of print.ABSTRACTRecent exciting developments in clustered regularly interspaced short palindromic repeats (CRISPR)-based genome editing showcase its potential to rapidly and efficiently edit genomes in planta, eliminating long processes of tissue culture and extensive breeding for crop improvement. These new methods offer heritable transgene-free edits in one generation, making them an attractive option for improving commercially important crops.PMID:37429772 | DOI:10.1016/j.tig.2023.06.009 (Source: Trends in Genetics : TIG)
Source: Trends in Genetics : TIG - July 10, 2023 Category: Genetics & Stem Cells Authors: Tofazzal Islam Shamfin Hossain Kasfy Source Type: research
CRISPR enables heritable genome editing in planta
Trends Genet. 2023 Jul 8:S0168-9525(23)00155-5. doi: 10.1016/j.tig.2023.06.009. Online ahead of print.ABSTRACTRecent exciting developments in clustered regularly interspaced short palindromic repeats (CRISPR)-based genome editing showcase its potential to rapidly and efficiently edit genomes in planta, eliminating long processes of tissue culture and extensive breeding for crop improvement. These new methods offer heritable transgene-free edits in one generation, making them an attractive option for improving commercially important crops.PMID:37429772 | DOI:10.1016/j.tig.2023.06.009 (Source: Trends in Genetics : TIG)
Source: Trends in Genetics : TIG - July 10, 2023 Category: Genetics & Stem Cells Authors: Tofazzal Islam Shamfin Hossain Kasfy Source Type: research
CRISPR enables heritable genome editing in planta
Trends Genet. 2023 Jul 8:S0168-9525(23)00155-5. doi: 10.1016/j.tig.2023.06.009. Online ahead of print.ABSTRACTRecent exciting developments in clustered regularly interspaced short palindromic repeats (CRISPR)-based genome editing showcase its potential to rapidly and efficiently edit genomes in planta, eliminating long processes of tissue culture and extensive breeding for crop improvement. These new methods offer heritable transgene-free edits in one generation, making them an attractive option for improving commercially important crops.PMID:37429772 | DOI:10.1016/j.tig.2023.06.009 (Source: Trends in Genetics : TIG)
Source: Trends in Genetics : TIG - July 10, 2023 Category: Genetics & Stem Cells Authors: Tofazzal Islam Shamfin Hossain Kasfy Source Type: research
CRISPR enables heritable genome editing in planta
Trends Genet. 2023 Jul 8:S0168-9525(23)00155-5. doi: 10.1016/j.tig.2023.06.009. Online ahead of print.ABSTRACTRecent exciting developments in clustered regularly interspaced short palindromic repeats (CRISPR)-based genome editing showcase its potential to rapidly and efficiently edit genomes in planta, eliminating long processes of tissue culture and extensive breeding for crop improvement. These new methods offer heritable transgene-free edits in one generation, making them an attractive option for improving commercially important crops.PMID:37429772 | DOI:10.1016/j.tig.2023.06.009 (Source: Trends in Genetics : TIG)
Source: Trends in Genetics : TIG - July 10, 2023 Category: Genetics & Stem Cells Authors: Tofazzal Islam Shamfin Hossain Kasfy Source Type: research
Ancient DNA reveals an early adoption of horse culture by Native Americans
Trends Genet. 2023 Jul 7:S0168-9525(23)00156-7. doi: 10.1016/j.tig.2023.06.010. Online ahead of print.ABSTRACTNative Americans of the Plains and Rocky Mountains are renowned for their horsemanship. Taylor et al. recently used ancient DNA and other bioarcheological approaches to document how horses dispersed throughout America and transformed Native American societies following their introduction by the Spanish in 1519, well before the arrival of European settlers.PMID:37423869 | DOI:10.1016/j.tig.2023.06.010 (Source: Trends in Genetics : TIG)
Source: Trends in Genetics : TIG - July 9, 2023 Category: Genetics & Stem Cells Authors: Ernest Bailey Source Type: research
Molecular mechanisms controlling vertebrate retinal patterning, neurogenesis, and cell fate specification
Trends Genet. 2023 Jul 7:S0168-9525(23)00133-6. doi: 10.1016/j.tig.2023.06.002. Online ahead of print.ABSTRACTThis review covers recent advances in understanding the molecular mechanisms controlling neurogenesis and specification of the developing retina, with a focus on insights obtained from comparative single cell multiomic analysis. We discuss recent advances in understanding the mechanisms by which extrinsic factors trigger transcriptional changes that spatially pattern the optic cup (OC) and control the initiation and progression of retinal neurogenesis. We also discuss progress in unraveling the core evolutionarily ...
Source: Trends in Genetics : TIG - July 9, 2023 Category: Genetics & Stem Cells Authors: Xin Zhang Patrick Leavey Haley Appel Neoklis Makrides Seth Blackshaw Source Type: research
Modeling the origin of cells
Trends Genet. 2023 Jul 7:S0168-9525(23)00157-9. doi: 10.1016/j.tig.2023.06.011. Online ahead of print.ABSTRACTProtocells (dividing supramolecular vesicles harboring unlinked genetic replicators) are thought to have played an important role in the origin and early evolution of life. Under what scenario did such reproducers come into play? New work by Babajanyan et al. provides theoretical insight into the symbiosis between replicators and reproducing compartments.PMID:37423871 | DOI:10.1016/j.tig.2023.06.011 (Source: Trends in Genetics : TIG)
Source: Trends in Genetics : TIG - July 9, 2023 Category: Genetics & Stem Cells Authors: E örs Szathmáry Source Type: research
Ancient DNA reveals an early adoption of horse culture by Native Americans
Trends Genet. 2023 Jul 7:S0168-9525(23)00156-7. doi: 10.1016/j.tig.2023.06.010. Online ahead of print.ABSTRACTNative Americans of the Plains and Rocky Mountains are renowned for their horsemanship. Taylor et al. recently used ancient DNA and other bioarcheological approaches to document how horses dispersed throughout America and transformed Native American societies following their introduction by the Spanish in 1519, well before the arrival of European settlers.PMID:37423869 | DOI:10.1016/j.tig.2023.06.010 (Source: Trends in Genetics : TIG)
Source: Trends in Genetics : TIG - July 9, 2023 Category: Genetics & Stem Cells Authors: Ernest Bailey Source Type: research
Molecular mechanisms controlling vertebrate retinal patterning, neurogenesis, and cell fate specification
Trends Genet. 2023 Jul 7:S0168-9525(23)00133-6. doi: 10.1016/j.tig.2023.06.002. Online ahead of print.ABSTRACTThis review covers recent advances in understanding the molecular mechanisms controlling neurogenesis and specification of the developing retina, with a focus on insights obtained from comparative single cell multiomic analysis. We discuss recent advances in understanding the mechanisms by which extrinsic factors trigger transcriptional changes that spatially pattern the optic cup (OC) and control the initiation and progression of retinal neurogenesis. We also discuss progress in unraveling the core evolutionarily ...
Source: Trends in Genetics : TIG - July 9, 2023 Category: Genetics & Stem Cells Authors: Xin Zhang Patrick Leavey Haley Appel Neoklis Makrides Seth Blackshaw Source Type: research
Modeling the origin of cells
Trends Genet. 2023 Jul 7:S0168-9525(23)00157-9. doi: 10.1016/j.tig.2023.06.011. Online ahead of print.ABSTRACTProtocells (dividing supramolecular vesicles harboring unlinked genetic replicators) are thought to have played an important role in the origin and early evolution of life. Under what scenario did such reproducers come into play? New work by Babajanyan et al. provides theoretical insight into the symbiosis between replicators and reproducing compartments.PMID:37423871 | DOI:10.1016/j.tig.2023.06.011 (Source: Trends in Genetics : TIG)
Source: Trends in Genetics : TIG - July 9, 2023 Category: Genetics & Stem Cells Authors: E örs Szathmáry Source Type: research
Linker H1 is an 'epi'centre of plant defence
Trends Genet. 2023 Jul 5:S0168-9525(23)00138-5. doi: 10.1016/j.tig.2023.06.007. Online ahead of print.ABSTRACTThe role of linker H1 histones in plant defence has recently been investigated. Sheikh et al. found that Arabidopsis thaliana plants that were lacking all three H1 proteins showed increased disease resistance, but when primed, failed to induce enhanced resistance. Differences in epigenetic patterns could be the cause of defective priming.PMID:37419697 | DOI:10.1016/j.tig.2023.06.007 (Source: Trends in Genetics : TIG)
Source: Trends in Genetics : TIG - July 7, 2023 Category: Genetics & Stem Cells Authors: Raghuram Badmi Barbara Doyle Prestwich Source Type: research
Mammalian aging driven by transcription going awry
Trends Genet. 2023 Jul 5:S0168-9525(23)00137-3. doi: 10.1016/j.tig.2023.06.006. Online ahead of print.ABSTRACTThe mechanisms that underlie increased cryptic transcription during senescence and aging have been poorly understood. Sen et al. recently identified cryptic transcription start sites (cTSSs) and chromatin state changes that may contribute to cTSS activation in mammals. Their results indicate that enhancer-promoter conversion may drive cryptic transcription in senescence.PMID:37419698 | DOI:10.1016/j.tig.2023.06.006 (Source: Trends in Genetics : TIG)
Source: Trends in Genetics : TIG - July 7, 2023 Category: Genetics & Stem Cells Authors: Brenna S McCauley Weiwei Dang Source Type: research
Linker H1 is an 'epi'centre of plant defence
Trends Genet. 2023 Jul 5:S0168-9525(23)00138-5. doi: 10.1016/j.tig.2023.06.007. Online ahead of print.ABSTRACTThe role of linker H1 histones in plant defence has recently been investigated. Sheikh et al. found that Arabidopsis thaliana plants that were lacking all three H1 proteins showed increased disease resistance, but when primed, failed to induce enhanced resistance. Differences in epigenetic patterns could be the cause of defective priming.PMID:37419697 | DOI:10.1016/j.tig.2023.06.007 (Source: Trends in Genetics : TIG)
Source: Trends in Genetics : TIG - July 7, 2023 Category: Genetics & Stem Cells Authors: Raghuram Badmi Barbara Doyle Prestwich Source Type: research
