Genetic distance informs polygenic score predictive accuracy

Trends Genet. 2023 Jul 29:S0168-9525(23)00160-9. doi: 10.1016/j.tig.2023.07.002. Online ahead of print.ABSTRACTPolygenic scores (PGSs) aggregate the effects of variants across the genome to estimate genetic liability, but have lower performance in external study populations. A new study by Ding et al. has applied a novel framework to estimate the individual-level predictive accuracy of PGSs, and demonstrates that performance reduction occurs linearly with genetic distance.PMID:37524625 | DOI:10.1016/j.tig.2023.07.002

Source: Trends in Genetics : TIG - July 31, 2023 Category: Genetics & Stem Cells Authors: Genevieve L Wojcik Source Type: research