Alginate-based 3D cell culture technique to evaluate the half-maximal inhibitory concentration: an in vitro model of anticancer drug study for anaplastic thyroid carcinoma
ConclusionsThe findings of this study are beneficial for developing in vitro ATC 3D models to analyze the efficacy of different chemotherapy drugs and formulations. (Source: Thyroid Research)
Source: Thyroid Research - December 3, 2021 Category: Endocrinology Source Type: research
Is Hashimoto thyroiditis associated with increasing risk of thyroid malignancies? A systematic review and meta-analysis
ConclusionAlthough we found a significant association between HT and some types of TCs, High RoB studies, high level of heterogeneity, and the limited number of well-designed prospective studies, suggested the need for more studies to reach more reliable evidence. (Source: Thyroid Research)
Source: Thyroid Research - December 3, 2021 Category: Endocrinology Source Type: research
Nutritional iodine status and obesity
AbstractIodine is an essential component of the thyroid hormones, thyroxine and triiodothyronine. Its availability strictly depends on iodine content of foods, which may vary from very low to very high. Inadequate iodine intake (deficiency or excess) may affect thyroid function resulting in hypothyroidism or hyperthyroidism. Based on median urinary iodine concentrations, epidemiological criteria have been established for the categorization and monitoring of nutritional iodine status of a population (or subgroups of populations). Additional methods for iodine intake assessment include measurement of thyroid size (by thyroid...
Source: Thyroid Research - November 27, 2021 Category: Endocrinology Source Type: research
Poorly differentiated thyroid carcinoma arising from a lithium-induced goiter in a patient with schizophrenia: a case report
ConclusionsThyroid examination of psychiatric patients who develop goiter due to long-term lithium treatment should be monitored regularly, and appropriate investigations and surgery should be performed in a timely manner if the goiter is growing rapidly. (Source: Thyroid Research)
Source: Thyroid Research - November 19, 2021 Category: Endocrinology Source Type: research
Undetectable thyroglobulin makes 123I whole-body scan and stimulated thyroglobulin obsolete in follow-up care of differentiated thyroid cancer: a retrospective study
ConclusionsThis study shows that an undetectable high-sensitive Tg can change the management of patients with DTC and decrease the use and need of stimulated Tg and123I WBS. (Source: Thyroid Research)
Source: Thyroid Research - October 19, 2021 Category: Endocrinology Source Type: research
The relationship between thyroid function and ovarian reserve: a prospective cross-sectional study
ConclusionOur study supports the relationship between TSH level and ovarian reserve so that with an increase in TSH from a certain level is associated with a decrease in ovarian function. (Source: Thyroid Research)
Source: Thyroid Research - October 1, 2021 Category: Endocrinology Source Type: research
Association between thyroid disorders and COVID-19: a protocol for a systematic review and meta-analysis
ConclusionResults of this study will provide current evidence on the association of COVID-19 diseases with any thyroid disorders such as hypothyroidism, thyrotoxicosis, and thyroid cancer with or without radioiodine therapy. Findings will be disseminated in peer-reviewed publications and conference presentations.Trial registration
PROSPERO registration number: CRD42020184289.https://www.crd.york.ac.uk/PROSPERO/#recordDetails (Source: Thyroid Research)
Source: Thyroid Research - September 29, 2021 Category: Endocrinology Source Type: research
Recurrence of carcinoma showing thymus-like differentiation (CASTLE) involving the thyroid gland
ConclusionsCASTLE is a rare disease, diagnosed based on postoperative pathology and immunohistochemistry analysis, especially upon CD5 marker. In case of relapse, treatment options include surgery and radiotherapy; however conservative management without intervention is an acceptable alternative in some cases. (Source: Thyroid Research)
Source: Thyroid Research - August 16, 2021 Category: Endocrinology Source Type: research
Development of metastatic poorly differentiated thyroid cancer from a sub-centimeter papillary thyroid carcinoma in a young patient with a germline MET mutation – association or random chance?
ConclusionsThe question of whether the observedMET mutation in any way influenced the dedifferentiation of a primary PTC into a PDTC metastasis remains to be established. Moreover, our data corroborate earlier studies, indicating thatMET is aberrantly expressed in PTC and may influence the invasive behavior of these tumors. (Source: Thyroid Research)
Source: Thyroid Research - August 14, 2021 Category: Endocrinology Source Type: research
How to use thionamide anti-thyroid drug in the young – what’s new?
AbstractThe excess thyroid hormone secretion that characterises Graves ’ disease (GD) is generated when stimulatory antibodies bind to the thyroid stimulating hormone receptor on the follicular cell of the thyroid gland.This underlying mechanism cannot easily be abolished and the mainstay of Graves ’ disease (GD) management in the young remains thionamide anti-thyroid drug (ATD). Unfortunately, GD will usually recur after a 2 or 3 year course of ATD, even when the stimulatory antibody titres have fallen. The diagnosis of GD therefore usually signals the start of a lengthy period of out-patie nt assessments and associat...
Source: Thyroid Research - July 21, 2021 Category: Endocrinology Source Type: research
Falsely diagnosed thyrotoxicosis caused by anti-streptavidin antibodies and pre-wash procedures
ConclusionsTo our knowledge, this is the first published report to clearly investigate such interferences using a combination of polyethylene glycol precipitation, heterophilic blocking tube precipitation, streptavidin-coated magnetic particle precipitation, and different instruments with or without pre-wash. Clinicians should consider that interferences caused by anti-streptavidin antibodies could lead to a misdiagnosis of thyrotoxicosis. Moreover, discussions between laboratory specialists, clinicians, and manufacturers are required to identify interferences and avoid unnecessary examinations and inappropriate treatment....
Source: Thyroid Research - July 10, 2021 Category: Endocrinology Source Type: research
Advanced thyroid carcinomas: neural network analysis of ultrasonographic characteristics
ConclusionsOur study has shown some evidence that advanced thyroid tumors demonstrate distinctive clinical and sonographic characteristics. Further prospective investigations with larger numbers of patients and multicenter design should be carried out to show whether a neural network incorporating these features may be an asset, helping to classify malignancies of the thyroid gland. (Source: Thyroid Research)
Source: Thyroid Research - June 29, 2021 Category: Endocrinology Source Type: research
Papillary thyroid microcarcinoma with lung metastases: a case report and review of the literature
ConclusionsLymph node metastasis or extraglandular extension has been reported in the few published cases of metastatic PTMC, including the present case, and the average age of these cases was 58.8 ± 12.0 years. Although active surveillance without surgical resection is expected to become a standard of care for PTMC, this case indicates that a subset of PTMC patients with risk factors may develop distant metastases. Hence, careful preoperative screening is required to avoid complicatio ns associated with completion thyroidectomy. (Source: Thyroid Research)
Source: Thyroid Research - June 11, 2021 Category: Endocrinology Source Type: research
Associations between maternal urinary iodine assessment, dietary iodine intakes and neurodevelopmental outcomes in the child: a systematic review
ConclusionThe majority of studies classified pregnant women to be mild-moderately iodine deficient based on urinary iodine assessment (UIC and/or ICr) and/or dietary intakes, with subsequent offspring neurodevelopment implications identified. Although a considerable number of studies did not report an adverse association with neurodevelopmental outcomes, these findings are still supportive of ensuring adequate dietary iodine intakes and urinary iodine monitoring throughout pregnancy due to the important role iodine plays within foetal neurodevelopment. This review suggests that dietary intake data may indicate a stronger a...
Source: Thyroid Research - June 7, 2021 Category: Endocrinology Source Type: research
Determination of calcium and parathyroid hormone levels following hemithyroidectomy
ConclusionsAlthough serum calcium level decreased after a lobectomy, it always remained above 4 mg/dl. We conclude that hypocalcaemia is rare following hemithyroidectomy. (Source: Thyroid Research)
Source: Thyroid Research - June 3, 2021 Category: Endocrinology Source Type: research
