Conservative management of low-risk papillary thyroid carcinoma: a review of the active surveillance experience
AbstractThe detection of low-risk thyroid carcinoma has increased in recent decades, although disease-specific mortality remained without changes. The high prevalence of occult carcinomas in autopsy studies, and hence the underlying indolent course of this entity, prompted the emergence of active surveillance as an alternative approach to these tumors. This strategy aims to recognize the minority group of patients who will develop clinical progression and probably benefit from deferred surgery. Experience around the world has shown that during active surveillance these tumors are mostly unchanged in size, with very-slow gr...
Source: Thyroid Research - March 13, 2023 Category: Endocrinology Source Type: research
Targeted therapy with vemurafenib in BRAF(V600E)-mutated anaplastic thyroid cancer
ConclusionsThis case and the review of current data confirm the benefit of BRAF inhibition in BRAF-mutated ATC, limited by acquired resistance to targeted therapy. (Source: Thyroid Research)
Source: Thyroid Research - March 1, 2023 Category: Endocrinology Source Type: research
Lobo-isthmectomy in the management of differentiated thyroid cancer
AbstractWe have recently witnessed a rapid increase in the incidence of differentiated thyroid carcinoma (DTC), particularly low and very low-risk papillary thyroid carcinoma. Simultaneously, the number of cancer-related deaths has remained stable for more than 30 years. Such an indolent nature and long-term survival prompted researchers and experts to an ongoing discussion on the adequacy of DTC management to avoid, on the one hand, the overtreatment of low-risk cases and, on the other hand, the undertreatment of highly aggressive ones.The most recent guidelines of the American Thyroid Association (ATA GL) moved primary...
Source: Thyroid Research - February 13, 2023 Category: Endocrinology Source Type: research
Hypothyroidism in hibernating brown bears
AbstractBrown bears hibernate throughout half of the year as a survival strategy to reduce energy consumption during prolonged periods with scarcity of food and water. Thyroid hormones are the major endocrine regulators of basal metabolic rate in humans. Therefore, we aimed to determine regulations in serum thyroid hormone levels in hibernation compared to the active state to investigate if these are involved in the adaptions for hibernation.We used electrochemiluminescence immunoassay to quantify total triiodothyronine (T3) and thyroxine (T4) levels in hibernation and active state in paired serum samples from six subadult...
Source: Thyroid Research - February 1, 2023 Category: Endocrinology Source Type: research
Pros and cons of an aggressive initial treatment with surgery and radioiodine treatment in minimally invasive follicular thyroid carcinoma
ConclusionTotal thyroidectomy and RAI ablation might have delayed the development of distant metastasis but they were not sufficient to avoid disease recurrence. Certainly, remnant ablation simplified the follow-up and the monitoring of serum thyroglobulin allowed the early detection of the biochemical recurrence, but didn ’t change the outcome of the disease. Moreover, because of this early detection the patient was exposed to useless biochemical and imaging examinations. The aim of this report is to discuss the pros and cons of an aggressive treatment of a patient with mi-FTC. (Source: Thyroid Research)
Source: Thyroid Research - January 16, 2023 Category: Endocrinology Source Type: research
Screening and treatment of brain metastasis from papillary thyroid carcinoma: a case series
ConclusionsBrain metastases from DTC are rare. MRI is the preferred imaging mobility to screen brain lesions in DTC. The primary treatment modalities are surgery and SRS. (Source: Thyroid Research)
Source: Thyroid Research - January 11, 2023 Category: Endocrinology Source Type: research
Incidence and treatment outcomes of Graves ’ disease in Thailand: a single-center retrospective observational study
ConclusionTreatment failure with ATD in patients with GD was frequent in this population. The diagnosis of GD based solely on clinical features may explain the high treatment failure rate in this study. More definitive treatment could be used to prevent relapse and complications of the disease. (Source: Thyroid Research)
Source: Thyroid Research - December 19, 2022 Category: Endocrinology Source Type: research
Case report: surgical management of symptomatic pretracheal thyroid gland in a patient with dual ectopic thyroid
ConclusionSurgical excision was used to manage a symptomatic cervical infrahyoid mass related to dual ectopic thyroid. Postoperatively, thyroid hormone replacement was required both to prevent enlargement of the remaining sublingual thyroid and to maintain adequate thyroid hormone levels. (Source: Thyroid Research)
Source: Thyroid Research - December 12, 2022 Category: Endocrinology Source Type: research
Solitary and multiple thyroid nodules as predictors of malignancy: a systematic review and meta-analysis
ConclusionThere is a higher incidence of thyroid cancer among patients of STN, however, given the low quality of existing evidence on the topic, it is crucial to conduct larger studies that can establish association with a greater precision. (Source: Thyroid Research)
Source: Thyroid Research - December 5, 2022 Category: Endocrinology Source Type: research
Retrospective observation of subacute thyroiditis before and during the COVID-19 vaccination campaign in a single secondary endocrine centre in the Savona district, Liguria, Italy
ConclusionTo date, few cases of SAT after COVID-19 vaccinations have been described in the literature, with sub-clinical, normal or increased thyroid function during 1-3-month follow-up. Our findings indicate that SAT after COVID-19 vaccination occurs more frequently than in other virus-related cases and at a greater age. Our observation of a local increase in SAT during the 2021 COVID-19 vaccination campaign indicates that physicians should be aware of this infrequent side effect, which must be considered and monitored after COVID-19 vaccination. (Source: Thyroid Research)
Source: Thyroid Research - November 2, 2022 Category: Endocrinology Source Type: research
Long term outcome after toxic nodular goitre
ConclusionOne advantage of treating TNG with RAI over surgery might be lost due to the seemingly similar incidence of hypothyroidism. The need for up to five treatments is rarely described and indicates that the treatment of TNG can be more complex than expected. This circumstance and the long-term QoL impairments are reminders of the chronic nature of hyperthyroidism from TNG. (Source: Thyroid Research)
Source: Thyroid Research - November 1, 2022 Category: Endocrinology Source Type: research
Interpretation of TSH and T4 for diagnosing minor alterations in thyroid function: a comparative analysis of two separate longitudinal cohorts
ConclusionThe distributions of thyroid function tests illustrated how TSH outperforms T4 for detecting delicate differences in thyroid function in an individual. Thus, TSH was markedly better than T4 to discriminate between the subtle differences in thyroid function corroborating that TSH is the more sensitive and accurate index of thyroid function status in the individual patient. (Source: Thyroid Research)
Source: Thyroid Research - October 10, 2022 Category: Endocrinology Source Type: research
Ventricular fibrillation immediately after the treatment of Graves ’ disease coexisting with atypical angina and long QT syndrome: a case report
ConclusionsWhen beta-blockers are administered to patients with Graves ’ disease who have severe chest symptoms, fatal arrhythmias are possible. ICD implantation should be considered for the secondary prevention of fatal arrhythmias. (Source: Thyroid Research)
Source: Thyroid Research - October 3, 2022 Category: Endocrinology Source Type: research
Optic nerve head optical coherence tomography angiography findings in patients with thyroid eye disease: a case –control study
ConclusionOur study showed non-significant ONH vascular alterations in patients with TED, including reduced VD of ONH in the radial peripapillary capillary. Patients with higher CAS scores had a more noticeable decrease in ONH microvasculature. (Source: Thyroid Research)
Source: Thyroid Research - September 21, 2022 Category: Endocrinology Source Type: research
A pregnant women with history of hashimoto's thyroiditis diagnosed with Kikuchi-Fujimoto disease: the first case report
ConclusionsFurther investigations need to be conducted to understand the possible autoimmune etiology of KFD when it is associated with Hashimoto's thyroiditis disease. It is also necessary to understand the relationship between this disease and pregnancy. (Source: Thyroid Research)
Source: Thyroid Research - September 15, 2022 Category: Endocrinology Source Type: research
