The upper limit for TSH during pregnancy: why we should stop using fixed limits of 2.5 or 3.0 mU/l
AbstractPhysiological changes necessitate the use of pregnancy-specific reference ranges for TSH and FT4 to diagnose thyroid dysfunction during pregnancy. Although many centers use fixed upper limits for TSH of 2.5 or 3.0 mU/L, this comment describeds new data which indicate that such cut-offs are too low and may lead to overdiagnosis or even overtreatment. The new guidelines of the American Thyroid Association have considerably changed recommendations regarding thyroid function reference ranges in pregnancy accord ingly. Also a stepwise approach to interpreting these guidelines is discussed as well as the relevant role ...
Source: Thyroid Research - May 21, 2018 Category: Endocrinology Source Type: research
Acute suppurative thyroiditis caused by thyroid papillary carcinoma in the right thyroid lobe of a healthy woman
ConclusionsThis report represents a rare case of AST associated with PTC on the right side of thyroid gland, found in a healthy adult woman. The reason why AST coincided with malignant thyroid tumor is unclear. We have to take it into our account that malignant tumor may exist in the background when AST is identified on the right side of thyroid gland with a healthy subject. (Source: Thyroid Research)
Source: Thyroid Research - May 15, 2018 Category: Endocrinology Source Type: research
Ultrasound criteria for risk stratification of thyroid nodules in the previously iodine deficient area of Austria - a single centre, retrospective analysis
ConclusionOur findings support the recently published EU-TIRADS score. Apart from mild hypoechogenicity, the analyzed ultrasound criteria can be applied for risk stratification of thyroid nodules in the previously severely iodine deficient population of Austria. (Source: Thyroid Research)
Source: Thyroid Research - May 9, 2018 Category: Endocrinology Source Type: research
Role of the T and B lymphocytes in pathogenesis of autoimmune thyroid diseases
AbstractAutoimmune thyroid disorders (AITD) broadly include Graves ’ disease and Hashimoto’s thyroiditis which are the most common causes of thyroid gland dysfunctions. These disorders develop due to complex interactions between environmental and genetic factors and are characterized by reactivity to self-thyroid antigens due to autoreactive lymphocytes escapin g tolerance. Both cell-mediated and humoral responses lead to tissue injury in autoimmune thyroid disease. The differentiation of CD4+ cells in the specific setting of immune mediators (for example cytokines, chemokines) results in differentiation of various T c...
Source: Thyroid Research - February 13, 2018 Category: Endocrinology Source Type: research
Management of hypothyroidism with combination thyroxine (T4) and triiodothyronine (T3) hormone replacement in clinical practice: a review of suggested guidance
ConclusionWhilst evidence is lacking on whether a small group of patients may benefit from combination therapy a trial may be indicated in those who remain symptomatic despite adequate levothyroxine monotherapy. This should be undertaken by clinicians experienced in the field with appropriate monitoring for adverse outcomes in both short and long term. (Source: Thyroid Research)
Source: Thyroid Research - January 17, 2018 Category: Endocrinology Source Type: research
Papillary thyroid cancer recurrence 43 Years following Total Thyroidectomy and radioactive iodine ablation: a case report
ConclusionThis case exemplifies the need for the head and neck surgeon, radiation oncologist, general practitioner and radiologist to consider new lateral neck mass as late-presenting recurrence of PTC until proven otherwise regardless of low recurrence rates beyond two decades from treatment and low prognostic risk scores. (Source: Thyroid Research)
Source: Thyroid Research - October 10, 2017 Category: Endocrinology Source Type: research
Hyalinizing trabecular tumor of the thyroid gland and its significant diagnostic issue
ConclusionsHistologically, HTT is a follicular cell-derived tumor composed of neoplastic cells arranged in a trabecular pattern with hyalinization and calcification of extracellular material. Distinguishing features of HTT include minimal cytologic atypia with a low nuclear: cytoplasmic ratio, cellular aggregates around hyalinized material, and nuclei with clumped chromatin and occasional grooves and/or pseudoinclusions. Though debated in the literature, the general consensus is that this tumor is a benign entity. It is our hope that additional clinical research will elicit awareness of these rare tumors. (Source: Thyroid Research)
Source: Thyroid Research - October 10, 2017 Category: Endocrinology Source Type: research
Papillary thyroid cancer recurrence 43 Years following Total Thyroidectomy and radioactive iodine ablation: a case report
ConclusionThis case exemplifies the need for the head and neck surgeon, radiation oncologist, general practitioner and radiologist to consider new lateral neck mass as late-presenting recurrence of PTC until proven otherwise regardless of low recurrence rates beyond two decades from treatment and low prognostic risk scores. (Source: Thyroid Research)
Source: Thyroid Research - October 10, 2017 Category: Endocrinology Source Type: research
Hyalinizing trabecular tumor of the thyroid gland and its significant diagnostic issue
ConclusionsHistologically, HTT is a follicular cell-derived tumor composed of neoplastic cells arranged in a trabecular pattern with hyalinization and calcification of extracellular material. Distinguishing features of HTT include minimal cytologic atypia with a low nuclear: cytoplasmic ratio, cellular aggregates around hyalinized material, and nuclei with clumped chromatin and occasional grooves and/or pseudoinclusions. Though debated in the literature, the general consensus is that this tumor is a benign entity. It is our hope that additional clinical research will elicit awareness of these rare tumors. (Source: Thyroid Research)
Source: Thyroid Research - October 10, 2017 Category: Endocrinology Source Type: research
