The interrelationship between pregnancy, venous thromboembolism, and thyroid disease: a hypothesis-generating review
In conclusion, a normal pregnancy entails hormonal changes, which influence the onset of VTE and thyroid disease. Current evidence suggests an association between thyroid disease and VTE in non-pregnant individuals. This review proposes the hypothesis that maternal thyroid disease associates with VTE in pregnant women and call for future research studies on this subject. If an association exists in pregnant women specifically, such findings may have clinical implications regarding strategies for thyroid function testing and potential thromboprophylaxis in selected individuals. (Source: Thyroid Research)
Source: Thyroid Research - May 25, 2021 Category: Endocrinology Source Type: research
Risk factors for transient and permanent congenital hypothyroidism: a population-based case-control study
ConclusionFamily history, neonatal jaundice, gestational age at birth, and Betadine usage in pregnancy are associated with CH. (Source: Thyroid Research)
Source: Thyroid Research - May 5, 2021 Category: Endocrinology Source Type: research
Thyroid hemiagenesis with a TI-RADS 2 nodule in the contralateral lobe
ConclusionThyroid hemiagenesis is often associated with other thyroid disorders. Its diagnosis should prompt an active search for other associated morphological or functional thyroid abnormalities. (Source: Thyroid Research)
Source: Thyroid Research - April 30, 2021 Category: Endocrinology Source Type: research
A case of thyrotoxicosis-induced anemia in a patient with painless thyroiditis
ConclusionsThis is the first case report of transient secondary anemia associated with thyrotoxicosis due to painless thyroiditis. The change in sIL-2R was also observed during the clinical course of thyrotoxicosis and anemia, suggesting the immune processes in thyroid gland and bone marrow. (Source: Thyroid Research)
Source: Thyroid Research - April 23, 2021 Category: Endocrinology Source Type: research
Clinical outcome of patients with differentiated thyroid cancer and raised antithyroglobulin antibody levels: a retrospective study
ConclusionHigh post-operative TgAb levels and central compartment lymph nodal metastases are risk factors for IR. RIT leads to a significant fall in the TgAb in these patients. The low level of raised TgAb is associated with an excellent outcome. Patients with recurrences had very high baseline TgAb> 1000 IU/ml. Raised TgAb was associated with good clinical outcomes and not associated with increased mortality. (Source: Thyroid Research)
Source: Thyroid Research - April 15, 2021 Category: Endocrinology Source Type: research
Prevalence of thyroid carcinoma in nodules with thy 3 cytology: the role of preoperative ultrasonography and strain elastography
ConclusionsIrregular margins, ill-defined borders, a taller than wide shape and low elasticity were associated with malignancy. Elastography should be performed when evaluating Thy3 nodules. (Source: Thyroid Research)
Source: Thyroid Research - April 9, 2021 Category: Endocrinology Source Type: research
Association between thyroid autoimmunity and ovarian reserve in women with hypothyroidism
ConclusionsNo significant alteration was found in the ovarian reserve of women with HT. (Source: Thyroid Research)
Source: Thyroid Research - March 22, 2021 Category: Endocrinology Source Type: research
Practice patterns and outcomes in the management of Thai patients with Graves ’ disease
ConclusionsOur present study highlighted the changing landscape of primary treatments for hyperthyroid GD toward ATD and the sharp downward trend in the surgical option. Even though ATD was associated with a low remission rate, it was preferred by many patients and physicians. The use of RAI as the primary treatment decreased in the last decade. However, RAI was a very effective treatment for Graves ’ hyperthyroidism but will inevitably induce hypothyroidism and a requirement for life-long replacement therapy. (Source: Thyroid Research)
Source: Thyroid Research - March 3, 2021 Category: Endocrinology Source Type: research
Pretibial myxedema in a euthyroid patient: a case report
ConclusionAbsence of history of thyroid disorder and normal thyroid function tests should not exclude the diagnosis of pretibial myxedema. (Source: Thyroid Research)
Source: Thyroid Research - March 1, 2021 Category: Endocrinology Source Type: research
Malignancy risk of hyperfunctioning thyroid nodules compared with non-toxic nodules: systematic review and a meta-analysis
ConclusionsOdds of malignancy of hot nodules is reduced compared with non-toxic nodules; however, the incidence of malignancy reported in hot nodules was higher than expected. These findings highlight the need for further studies into the malignancy risk of hot nodules. (Source: Thyroid Research)
Source: Thyroid Research - February 25, 2021 Category: Endocrinology Source Type: research
Factors affecting thyroid nodule fine needle aspiration non ‐diagnostic rates: a retrospective association study of 1975 thyroid biopsies
ConclusionsThe results from this study demonstrate that thyroid FNAs performed with bedside ROSE can significantly reduce the ND rate compared with non-ROSE, even in experienced groups with low initial ND rates. It is therefore imperative that care providers managing patients with thyroid nodules ensure that thyroid FNAs are referred to specialized individuals/groups who do high volume, and ideally with the use of bedside ROSE, whether provided by a cytotechnologist or a pathologist. (Source: Thyroid Research)
Source: Thyroid Research - February 10, 2021 Category: Endocrinology Source Type: research
Hyperthyroidism in gestational trophoblastic disease – a literature review
ConclusionEarly detection of GTD is critical to prevent development of hyperthyroidism and its associated complications. Hyperthyroidism should be recognised as an important perioperative consideration for women undergoing surgery for GTD, and requires appropriate management. Future studies should explore risk factors for hyperthyroidism in GTD, which may facilitate earlier identification of high-risk women. (Source: Thyroid Research)
Source: Thyroid Research - January 14, 2021 Category: Endocrinology Source Type: research
Recent advances in the management of anaplastic thyroid cancer
AbstractAnaplastic thyroid cancer (ATC) is undoubtedly the thyroid cancer histotype with the poorest prognosis. The conventional treatment includes surgery, radiotherapy, and conventional chemotherapy. Surgery should be as complete as possible, securing the airway and ensuring access for nutritional support; the current standard of care of radiotherapy is the intensity-modulated radiation therapy; chemotherapy includes the use of doxorubicin or taxanes (paclitaxel or docetaxel) generally with platin (cisplatin or carboplatin). However, frequently, these treatments are not sufficient and a systemic treatment with kinase inh...
Source: Thyroid Research - November 24, 2020 Category: Endocrinology Source Type: research
Selenium and at-risk pregnancy: challenges and controversies
AbstractSelenium (Se), an essential trace element, is inserted as selenocysteine into an array of functional proteins and forms the core of various enzymes that play a cardinal role in antioxidant defense mechanisms, in redox regulation, and in thyroid hormone metabolism. Variations in plasma Se are due to nutritional habits, geographic and ethnic differences, and probably to genetic polymorphisms, the latter still to be conclusively established. Se concentrations were reported to be low in women of reproductive age in the UK, decreasing further during pregnancy, this resulting in low plasma and placental antioxidant enzym...
Source: Thyroid Research - September 30, 2020 Category: Endocrinology Source Type: research
Can we safely reduce the administration of 131-iodine in patients with differentiated thyroid cancer? – experience of the Brugmann hospital in Brussels
ConclusionsUsing the 2015-ATA evidence-based guidelines for the management of DTC, meaning no131I administration in low-risk patients, a low activity in intermediate and even high risk patients, and a systematic use of rhTSH stimulation before131I therapy allowed us to reduce significantly the median administered131I activity, with a similar rate of complete therapeutic response. (Source: Thyroid Research)
Source: Thyroid Research - September 11, 2020 Category: Endocrinology Source Type: research
