Undetectable thyroglobulin makes 123I whole-body scan and stimulated thyroglobulin obsolete in follow-up care of differentiated thyroid cancer: a retrospective study

ConclusionsThis study shows that an undetectable high-sensitive Tg can change the management of patients with DTC and decrease the use and need of stimulated Tg and123I WBS.
Source: Thyroid Research - Category: Endocrinology Source Type: research

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Conclusions: To the best of our knowledge, this is the first reported case of a large thyroid carcinoma that was effectively treated by 3D-printed template-guided125I seed brachytherapy.Eur Thyroid J
Source: European Thyroid Journal - Category: Endocrinology Source Type: research
Conclusion: As for DTC, pregnancy seems to represent a stimulus to malignant SO growth. This can be caused by the high levels of estrogen during pregnancy that may bind to receptors in malignant cells and/or by the high levels of hCG which is known to stimulate TSH receptors.Eur Thyroid J
Source: European Thyroid Journal - Category: Endocrinology Source Type: research
Conclusions Ultrasound is less sensitive than 131I posttherapy scans for ThR detection in patients after thyroidectomy, especially for remnants located above the lower margin of thyroid cartilage.
Source: Clinical Nuclear Medicine - Category: Nuclear Medicine Tags: Original Articles Source Type: research
ConclusionsIn routine clinical practice, the Martinique Principles should be implemented in order to optimize clinical management/outcomes of patients with DTC.
Source: Endocrine - Category: Endocrinology Source Type: research
Authors: Barrea L, Fonderico F, Di Somma C, Pugliese G, De Alteriis G, Mascolo M, Colao A, Savastano S Abstract The prevalence of ectopic thyroid tissue as consequence of an aberrant migration of thyroid during embryogenesis ranges up to 10% in autopsy studies. The differential diagnosis between the relatively rare occurrence of a primary carcinoma arising in ectopic thyroid tissue and the more frequent presence of cervical lymph node metastasis from papillary thyroid carcinoma (PTC) might represent a difficult challenge in the clinical practice. The clinical relevance of these lesions lies in their risk of hidden ...
Source: Minerva Endocrinologica - Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Conclusion: We developed the methodology, 'Tulchinsky Tg/RAIU Reconciliation', for calculating maximum Tg that could be attributed to RBT under hormone withdrawal stimulation (maxTg-RBT), based on measured 24-hour RAIU over the thyroid bed. This method informs us with high level of specificity (97%) that patients have no occult DTC after TT when measured Tg is below the maxTg-RBT, and they are most suitable for remnant ablation. The inverse logical extrapolation (that requires further study/confirmation) is that patients whose Tg calculates above the maxTg-RBT may have metastatic or residual microscopic DTC; therefore, the...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: New Trends in Endocrine Therapy Source Type: research
Conclusions: If one could achieve initial R0 dissection in low and intermediate risk DTC patients, the requirement of remnant ablation/adjuvant RAI therapy becomes superfluous, in view of very low recurrence rate (overall 3.6%, 2.6% in low and 6.4% in intermediate risk group) with median follow up of 69 months. However, current criteria for risk stratification to call low and intermediate risk DTC needs further refinement.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: New Trends in Endocrine Therapy Source Type: research
CONCLUSIONS: To our knowledge, this is the first case report describing GD/GO induced by a low activity RAI and the presence of a thyroid remnant after total thyroidectomy. RAI-induced GD/GO should be considered in the differential diagnosis of TPO-positive patients, even if their thyroids had been removed. PMID: 32293702 [PubMed - as supplied by publisher]
Source: Endokrynologia Polska - Category: Endocrinology Authors: Tags: Endokrynol Pol Source Type: research
CONCLUSIONS: In patients with no evidence of disease during the first 2 years of follow-up, the addition of stimulated-Tg adds little prognostic information. We suggest the use of excellent response to therapy based on basal Tg together with TxWBS and structural imaging studies. PMID: 31928205 [PubMed - as supplied by publisher]
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
In conclusion, the present case is an extremely rare occurrence of simultaneous multiple RDMs from PTC as the initial presentation.
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
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