Undetectable thyroglobulin makes 123I whole-body scan and stimulated thyroglobulin obsolete in follow-up care of differentiated thyroid cancer: a retrospective study
ConclusionsThis study shows that an undetectable high-sensitive Tg can change the management of patients with DTC and decrease the use and need of stimulated Tg and123I WBS.
Conclusions: To the best of our knowledge, this is the first reported case of a large thyroid carcinoma that was effectively treated by 3D-printed template-guided125I seed brachytherapy.Eur Thyroid J
Conclusion: As for DTC, pregnancy seems to represent a stimulus to malignant SO growth. This can be caused by the high levels of estrogen during pregnancy that may bind to receptors in malignant cells and/or by the high levels of hCG which is known to stimulate TSH receptors.Eur Thyroid J
Conclusions Ultrasound is less sensitive than 131I posttherapy scans for ThR detection in patients after thyroidectomy, especially for remnants located above the lower margin of thyroid cartilage.
ConclusionsIn routine clinical practice, the Martinique Principles should be implemented in order to optimize clinical management/outcomes of patients with DTC.
Authors: Barrea L, Fonderico F, Di Somma C, Pugliese G, De Alteriis G, Mascolo M, Colao A, Savastano S Abstract The prevalence of ectopic thyroid tissue as consequence of an aberrant migration of thyroid during embryogenesis ranges up to 10% in autopsy studies. The differential diagnosis between the relatively rare occurrence of a primary carcinoma arising in ectopic thyroid tissue and the more frequent presence of cervical lymph node metastasis from papillary thyroid carcinoma (PTC) might represent a difficult challenge in the clinical practice. The clinical relevance of these lesions lies in their risk of hidden ...
Conclusion: We developed the methodology, 'Tulchinsky Tg/RAIU Reconciliation', for calculating maximum Tg that could be attributed to RBT under hormone withdrawal stimulation (maxTg-RBT), based on measured 24-hour RAIU over the thyroid bed. This method informs us with high level of specificity (97%) that patients have no occult DTC after TT when measured Tg is below the maxTg-RBT, and they are most suitable for remnant ablation. The inverse logical extrapolation (that requires further study/confirmation) is that patients whose Tg calculates above the maxTg-RBT may have metastatic or residual microscopic DTC; therefore, the...
Conclusions: If one could achieve initial R0 dissection in low and intermediate risk DTC patients, the requirement of remnant ablation/adjuvant RAI therapy becomes superfluous, in view of very low recurrence rate (overall 3.6%, 2.6% in low and 6.4% in intermediate risk group) with median follow up of 69 months. However, current criteria for risk stratification to call low and intermediate risk DTC needs further refinement.
CONCLUSIONS: To our knowledge, this is the first case report describing GD/GO induced by a low activity RAI and the presence of a thyroid remnant after total thyroidectomy. RAI-induced GD/GO should be considered in the differential diagnosis of TPO-positive patients, even if their thyroids had been removed. PMID: 32293702 [PubMed - as supplied by publisher]
CONCLUSIONS: In patients with no evidence of disease during the first 2 years of follow-up, the addition of stimulated-Tg adds little prognostic information. We suggest the use of excellent response to therapy based on basal Tg together with TxWBS and structural imaging studies. PMID: 31928205 [PubMed - as supplied by publisher]
In conclusion, the present case is an extremely rare occurrence of simultaneous multiple RDMs from PTC as the initial presentation.