Enoxaparin for symptomatic COVID-19 managed in the ambulatory setting: An individual patient level analysis of the OVID and ETHIC trials
Antithrombotic treatment may improve the disease course in non-critically ill, symptomatic COVID-19 outpatients. (Source: Thrombosis Research)
Source: Thrombosis Research - August 17, 2023 Category: Hematology Authors: Stefano Barco, Saverio Virdone, Andrea G ötschi, Walter Ageno, Juan I. Arcelus, Roland Bingisser, Giuseppe Colucci, Frank Cools, Daniel Duerschmied, Harry Gibbs, Riccardo M. Fumagalli, Bernhard Gerber, Sylvia Haas, Jelle C.L. Himmelreich, Richard Hobbs, Tags: Full Length Article Source Type: research
Factor V Leiden, prothrombin, MTHFR, and PAI-1 gene polymorphisms in patients with arterial disease: A comprehensive systematic-review and meta-analysis
The role of inherited thrombophilia in arterial disease is uncertain. We performed a systematic-review and meta-analysis of inherited thrombophilia in cerebrovascular (CVD), coronary heart (CHD), and peripheral artery disease (PAD) patients. (Source: Thrombosis Research)
Source: Thrombosis Research - August 16, 2023 Category: Hematology Authors: Emanuele Valeriani, Daniele Pastori, Giulia Astorri, Angelo Porfidia, Danilo Menichelli, Pasquale Pignatelli Tags: Full Length Article Source Type: research
ROS-driven structural and functional fibrinogen modifications are reverted by interleukin-6 inhibition in giant cell arteritis
Cranial and extra-cranial vascular events are among the major determinants of morbidity and mortality in Giant Cell Arteritis (GCA). Vascular events seem mostly of inflammatory nature, although the precise pathogenetic mechanisms are still unclear. We investigated the role of oxidation-induced structural and functional fibrinogen modifications in GCA. The effects of the anti-IL6R tocilizumab in counteracting these mechanisms were also assessed. (Source: Thrombosis Research)
Source: Thrombosis Research - August 15, 2023 Category: Hematology Authors: Alessandra Bettiol, Flavia Rita Argento, Eleonora Fini, Federica Bello, Gerardo Di Scala, Niccol ò Taddei, Giacomo Emmi, Domenico Prisco, Matteo Becatti, Claudia Fiorillo Source Type: research
Functional analysis of two abnormal antithrombin proteins with different intracellular kinetics
In this study, we analyzed the mechanism by which these abnormal variants cause type I AT deficiency. (Source: Thrombosis Research)
Source: Thrombosis Research - August 15, 2023 Category: Hematology Authors: Yuta Imai, Satomi Nagaya, Yuhei Araiso, Makiko Meguro-Horike, Tomoki Togashi, Shin-ichi Horike, Hiroshi Kawasaki, Eriko Morishita Tags: Full Length Article Source Type: research
Assessment of the individual determinants of two fibrinolysis assays, GFC and ECLT in platelet-depleted plasma and derived euglobulin fraction respectively
Fibrinolysis plays a critical role in maintaining the balance between clot formation and dissolution. Its regulation is complex and involves a delicate interplay between several factors, as summarized in Supplementary material Fig. S1. Several laboratory methods evaluate the fibrinolytic system, but no reference and standardised in vitro assay is currently available [1,2]. The absence of a fibrinolysis assay with suitable analytical performance is of clinical importance. Indeed, many patients with a convincing history of mild bleeding disorder (MBD) show no laboratory abnormality despite extensive and repeated laboratory w...
Source: Thrombosis Research - August 13, 2023 Category: Hematology Authors: Marion Bareille, Thomas Lecompte, Fran çois Mullier Tags: Letter to the Editors-in-Chief Source Type: research
Prediction of in-hospital bleeding in acutely ill medical patients: External validation of the IMPROVE bleeding risk score
Pharmacological thromboprophylaxis slightly increases bleeding risk. The only risk assessment model to predict bleeding in medical inpatients, the IMPROVE bleeding risk score, has never been validated using prospectively collected outcome data. (Source: Thrombosis Research)
Source: Thrombosis Research - August 12, 2023 Category: Hematology Authors: Rahel Villiger, Pauline Juillard, Pauline Darbellay Farhoumand, Damien Choffat, Tobias Tritschler, Odile Stalder, Jean-Beno ît Rossel, Drahomir Aujesky, Marie Méan, Christine Baumgartner Source Type: research
Natural Language Processing tool accurately identifies acute venous thromboembolism
As of 2016, 1,200,000 DVT (deep vein thrombosis) and PE (pulmonary embolism) were diagnosed in the United States annually (collectively called venous thromboembolism (VTE)) [1]. Once VTE is diagnosed, an International Classification of Disease (ICD) code will be assigned which allows billing of the patient visit and identification of diagnoses within the Electronic Health Record (EHR). (Source: Thrombosis Research)
Source: Thrombosis Research - August 12, 2023 Category: Hematology Authors: David M. Scott, Abdi Abud, Mostafa Amor, Arash Saemi, Lisa Baumann Kreuziger, Damon Houghton Tags: Letter to the Editors-in-Chief Source Type: research
Predictors of cancer in patients with acute pulmonary embolism
Acute pulmonary embolism (PE) can occur as a manifestation of an underlying cancer and be of paraneoplastic aetiology. A previously unknown cancer is sometimes diagnosed after the acute PE diagnosis. The identification of a group of patients with elevated probability of having an occult cancer underlying PE was never performed. We aimed to determine predictors of occult cancer in acute PE. Our hypothesis was that the D-dimer levels would be a predictor of cancer. (Source: Thrombosis Research)
Source: Thrombosis Research - August 10, 2023 Category: Hematology Authors: Gon çalo Felix, Ester Ferreira, Ana Ribeiro, Inês Guerreiro, Emanuel Araújo, Sara Ferreira, Sara Coelho, Helena Magalhães, Jorge Almeida, Patrícia Lourenço Source Type: research
Thrombus architecture is influenced by the antiplatelet loading treatment in patients with acute myocardial infarction
Intracoronary thrombus formation is a main cause of acute myocardial infarction triggered by platelet activation. However, there are no data on the impact of different treatment strategies with antiplatelet agents before percutaneous coronary intervention (PCI) on histological characteristics of thrombus formation. (Source: Thrombosis Research)
Source: Thrombosis Research - August 10, 2023 Category: Hematology Authors: Tobias Harm, Dominik Rath, Klaus-Peter Kreisselmeier, Livia Baas, Carolin Prang, Sarah Gekeler, Stephen Schr öder, Meinrad Paul Gawaz, Tobias Geisler, Iris Irmgard Müller, Karin Anne Lydia Müller Tags: Full Length Article Source Type: research
Implications of bleeding on subsequent cardiovascular events in patients with atrial fibrillation after acute coronary syndrome or PCI
The association between bleeding and subsequent major adverse cardiac and cerebrovascular events (MACCE) remains poorly characterized. We aimed to evaluate the impact of hemorrhagic events in patients with atrial fibrillation (AF) and acute coronary syndrome (ACS) or undergoing percutaneous coronary intervention (PCI). (Source: Thrombosis Research)
Source: Thrombosis Research - August 6, 2023 Category: Hematology Authors: Ran Mo, Hao-Yu Wang, Yan-min Yang, Han Zhang, Ni Suo, Jing-yang Wang Tags: Full Length Article Source Type: research
External validation of AF-BLEED for predicting major bleeding and for tailoring NOAC dose in AF patients: A post hoc analysis in the ENGAGE AF-TIMI 48
AF-BLEED, a simple bleeding risk classifier, was found to predict major bleeding (MB) in patients with atrial fibrillation (AF) and identify AF patients at high risk of MB who might potentially benefit from a lower direct oral anticoagulant dose. This post hoc study aimed to externally validate these findings in the ENGAGE AF-TIMI 48 (Effective aNticoaGulation with factor Xa next Generation in Atrial Fibrillation –Thrombolysis in Myocardial Infarction study 48) trial. (Source: Thrombosis Research)
Source: Thrombosis Research - August 1, 2023 Category: Hematology Authors: G. Chu, L. Valerio, S. Barco, M.V. Huisman, S.V. Konstantinides, F.A. Klok Tags: Full Length Article Source Type: research
The clinical topography of peripherally inserted central catheter-related thrombosis in cancer patients: A prospective and longitudinal observational study based on ultrasound scans every two days
To delineate the clinical topography of peripherally inserted central catheter (PICC)-related thrombosis in cancer patients. (Source: Thrombosis Research)
Source: Thrombosis Research - July 31, 2023 Category: Hematology Authors: Xiaoxia Zhang, Hongxiu Chen, Wenli Jing, Lihui Pu, Zhoupeng Wu, Xiaotian Su, Huirong Chen, Juan Liu, Huaqin Yu, Xiuying Hu Tags: Full Length Article Source Type: research
D-dimer to fibrinogen ratio predicts early neurological deterioration in ischemic stroke with atrial fibrillation
The D-dimer to fibrinogen ratio (DFR) is a good indicator of clot-producing activity in thrombotic disease, but its clinical usefulness in stroke patients with nonvalvular atrial fibrillation (NVAF) has not been studied. We evaluated the association between the DFR and early neurological deterioration (END) in acute ischemic stroke (AIS) patients with NVAF. (Source: Thrombosis Research)
Source: Thrombosis Research - July 31, 2023 Category: Hematology Authors: Ki-Woong Nam, Chi Kyung Kim, Sungwook Yu, Kyungmi Oh, Jong-Won Chung, Oh. Young Bang, Gyeong-Moon Kim, Jin-Man Jung, Tae-Jin Song, Yong-Jae Kim, Bum Joon Kim, Sung Hyuk Heo, Kwang-Yeol Park, Jeong-Min Kim, Jong-Ho Park, Jay Chol Choi, Man-Seok Park, Joon- Tags: Full Length Article Source Type: research
CT coronary calcium score is a prognostic marker in acute pulmonary embolism
Acute pulmonary embolism (APE) is a possible life-threatening cardiovascular disease with 30-day mortality rates ranging from 0.5 % to>20 % depending on clinical symptoms at presentation [1]. Computed tomography pulmonary angiography (CTPA) is the gold standard for diagnosis of acute PE with high sensitivity and specificity [2]. (Source: Thrombosis Research)
Source: Thrombosis Research - July 26, 2023 Category: Hematology Authors: Hans-Jonas Meyer, Sebastian Gottschling, Caroline B är, Andreas Wienke, Alexey Surov Tags: Letter to the Editors-in-Chief Source Type: research
Bivalirudin or heparin for systemic anticoagulation during pediatric extracorporeal membrane oxygenation: Multicenter retrospective study
The objective of this study is to evaluate the outcomes of unfractionated heparin (UFH) compared to bivalirudin anticoagulation in pediatric ExtraCorporeal Membrane Oxygenation (ECMO). (Source: Thrombosis Research)
Source: Thrombosis Research - July 24, 2023 Category: Hematology Authors: Mohammed Hamzah, Troy G. Seelhammer, Asaad G. Beshish, Jonathan Byrnes, Mouhammad Yabrodi, Adam Szadkowski, Riad Lutfi, Nicole Andrijasevic, Kristal Hock, Sarah Worley, Duncan J. Macrae Tags: Full Length Article Source Type: research
