Driver gene KRAS aggravates cancer-associated stroke outcomes
The incidence of cancer-associated stroke has increased with the prolonged survival times of cancer patients. Recent genetic studies have led to progress in cancer therapeutics, but relationships between oncogenic mutations and stroke remain elusive. Here, we focused on the driver gene KRAS, which is the predominant RAS isoform mutated in multiple cancer types, in cancer associated stroke study. KRASG13D/ − and parental human colorectal carcinoma HCT116 cells were inoculated into mice that were then subjected to a photochemically-induced thrombosis model to establish ischemic stroke. (Source: Thrombosis Research)
Source: Thrombosis Research - November 18, 2023 Category: Hematology Authors: Haomin Yan, Tsutomu Sasaki, Yasufumi Gon, Kumiko Nishiyama, Hideaki Kanki, Hideki Mochizuki Tags: Full Length Article Source Type: research
A survey of clinician perspectives on the management of catheter-related upper extremity deep vein thrombosis in patients with cancer
Patients with cancer have an increased risk of venous thromboembolism (VTE) compared to those without cancer [1]. Many risk factors contribute to the increased risk, among which a central venous catheter (CVC) is a major one [2]. CVCs are commonly used in patients with cancer to facilitate blood draws and administer chemotherapy or other supportive care treatment. Catheter-related upper extremity deep vein thrombosis (DVT) is a major complication of CVCs, with studies reporting a rate of symptomatic VTE of 7 % over 3 months in patients with active cancer and a new CVC [3]. (Source: Thrombosis Research)
Source: Thrombosis Research - November 15, 2023 Category: Hematology Authors: Tzu-Fei Wang, Aur élien Delluc, Andrea Cervi, Danny Hill, Michael J. Kovacs, Chantal Séguin, Tim Ramsay, Marc Carrier Tags: Letter to the Editors-in-Chief Source Type: research
Trimethylamine-N-oxide (TMAO) and basic fibroblast growth factor (bFGF) are possibly involved in corticosteroid resistance in adult patients with immune thrombocytopenia
Immune thrombocytopenia (ITP) is an autoimmune disease characterized by accelerated platelet clearance. Gut dysbiosis was associated with its pathogenesis, but the underlying mechanisms have not been fully elucidated. Patients with ITP exhibit varying degrees of responsiveness to corticosteroid treatment. Therefore, prognostic indexes for corticosteroid responsiveness in ITP could offer valuable guidance for clinical practices. (Source: Thrombosis Research)
Source: Thrombosis Research - November 15, 2023 Category: Hematology Authors: Lei Liu, Huifang Xu, Jian Wang, Haiyan Wang, Saisai Ren, Qian Huang, Mingyan Zhang, Hui Zhou, Chunyan Yang, Lu Jia, Yu Hang, Hao Zhang, Yanling Tao, Ying Li, Yanan Min Tags: Full Length Article Source Type: research
Initiation of warfarin is associated with decreased mortality in patients with infective endocarditis: A population-based cohort study
The use of warfarin to prevent thromboembolism in patients with infective endocarditis (IE) remains controversial due to potentially increased bleeding risks. (Source: Thrombosis Research)
Source: Thrombosis Research - November 14, 2023 Category: Hematology Authors: Teddy Tai Loy Lee, Sunny Ching Long Chan, Oscar Hou In Chou, Sharen Lee, Jeffrey Shi Kai Chan, Tong Liu, Carlin Chang, Wing Tak Wong, Gregory Y.H. Lip, Bernard Man Yung Cheung, Abraham Ka-Chung Wai, Gary Tse Source Type: research
Brief report: High incidence of peridiagnosis thromboembolic events in patients with BRAF-mutant lung cancer
We aimed to determine if advanced BRAF-mutant NSCLC has a higher thromboembolic events (TEE) rate than the expected. (Source: Thrombosis Research)
Source: Thrombosis Research - November 12, 2023 Category: Hematology Authors: Inmaculada Aparicio, Patricia Iranzo, Roxana Reyes, Helena Bote, Mar ía Saigi, Marianela Bringas, Joaquim Bosch-Barrera, Jesús Corral, Francisco Aparisi, Jose C. Ruffinelli, Beatriz Jiménez, Yolanda Lage, Rafael López-Castro, Margarita Majem, Sergio V Source Type: research
Comparison of risk prediction scores for cancer-associated thrombosis in ambulatory cancer patients not receiving thromboprophylaxis: A prospective cohort study in a South-East Asian population
To date, there is limited data regarding the incidence and risk prediction of cancer-associated thrombosis among South-East Asian patients not receiving thromboprophylaxis. (Source: Thrombosis Research)
Source: Thrombosis Research - November 12, 2023 Category: Hematology Authors: Sittikul Thipbumrung, Piangrawee Niprapan, Prapaporn Suprasert, Thanika Ketpueak, Adisak Tantiworawit, Teerachat Punnachet, Nonthakorn Hantrakun, Pokpong Piriyakhuntorn, Thanawat Rattanathammethee, Sasinee Hantrakool, Ekarat Rattarittamrong, Lalita Norase Tags: Full Length Article Source Type: research
Unveiling the predictive capacity of inflammatory and platelet markers for central retinal artery occlusion
This study aims to evaluate the predictive value of neutrophil-to-lymphocyte ratio (NLR), systemic Immunoinflammatory Index (SII), and systemic Inflammatory Response Index (SIRI), and platelet distribution width (PDW) for the occurrence of non-arteritic Central retinal artery occlusion (NA-CRAO). (Source: Thrombosis Research)
Source: Thrombosis Research - November 10, 2023 Category: Hematology Authors: Yupeng Zhang, Zhen Xing, Aijun Deng Tags: Letter to the Editors-in-Chief Source Type: research
A novel mutation p.Met1Val in SERPINC1 gene causes hereditary antithrombin deficiency in a Chinese family with thrombotic disease
Venous thromboembolism (VTE), which includes deep vein thrombosis (DVT) and pulmonary embolism (PE), is the second most common cardiovascular disease after myocardial infarction, affecting approximately 10 million people worldwide each year [1]. Genetic factors can now be found in up to 30 % of VTE patients, including factor V Leiden and the prothrombin G20210A mutations which mainly be found in Europe and the United States. Other inherited thrombotic disorders, such as antithrombin, protein C and protein S deficiency, are relatively rare but result in a higher risk of thrombosis. (Source: Thrombosis Research)
Source: Thrombosis Research - November 10, 2023 Category: Hematology Authors: Manlin Zeng, Kaiqi Jia, Meina Liu, Mingshan Wang, Lihong Yang, Haixiao Xie Tags: Letter to the Editors-in-Chief Source Type: research
Comparing U.S. and Canadian treatment patterns on venous thromboembolism outcomes in the GARFIELD-VTE registry
Economically developed countries continue to find that venous thromboembolism (VTE) is a major cause of morbidity and mortality. (Source: Thrombosis Research)
Source: Thrombosis Research - November 8, 2023 Category: Hematology Authors: Adrian C. Chen, Amit S. Rao, Alisha Oropallo, Samuel Z. Goldhaber, Meg E. Fluharty, Uma Maheshwari, Marc Carrier, Alexander G.G. Turpie, Karen Pieper, Gloria Kayani, Ajay K. Kakkar, GARFIELD-VTE investigators Tags: Full Length Article Source Type: research
Risk factors for serious adverse events related to vitamin K antagonists in children with congenital or acquired heart disease: a prospective cohort study
To assess the occurrence of thrombosis and major bleeding in children with congenital or acquired heart disease (CAHD) treated with VKA and to identify risk factors for these serious adverse events (SAE). (Source: Thrombosis Research)
Source: Thrombosis Research - November 7, 2023 Category: Hematology Authors: Fanny Bajolle, Neil Derridj, Joan Bitan, Aurelie Grazioli, Nicolas Pallet, Dominique Lasne, Damien Bonnet Source Type: research
Safety of fixed-dose heparin titration boluses in underweight patients
At UNC, venous thromboembolism (VTE) patients are treated with a heparin nomogram including fixed-dose titration boluses to correct subtherapeutic heparin correlation values (HCVs). The bolus dose often exceeds the recommended loading dose in underweight patients, therefore raising concern for an increased bleeding risk. This evaluation aims to assess the safety of these titration boluses for underweight patients. (Source: Thrombosis Research)
Source: Thrombosis Research - November 7, 2023 Category: Hematology Authors: Roxanne McKnight, Mohammad Salameh, Lee Ann Jones, Greta Anton, Lindsay Carter Source Type: research
Are the latest point-of-care D-dimer devices ready for use in general practice? A prospective clinical evaluation of five test systems with a capillary blood feature for suspected venous thromboembolism
We evaluated clinical performance of five novel point-of-care (POC) D-dimer devices with a capillary finger stick feature for predicting venous thromboembolism (VTE) in general practice: Exdia TRF Plus (E), AFIAS-1 ® (A), Standard F200® (S), LumiraDx™ (L) and Hipro AFS/1® (H). (Source: Thrombosis Research)
Source: Thrombosis Research - November 5, 2023 Category: Hematology Authors: J.S. Heerink, R. Oudega, E. Gemen, R. Hopstaken, H. Koffijberg, R. Kusters Tags: Full Length Article Source Type: research
Gut dysbiosis-related thrombosis in inflammatory bowel disease: Potential disease mechanisms and emerging therapeutic strategies
Patients with inflammatory bowel disease (IBD) have an increased risk of developing venous thromboembolic events, which have a considerable impact on morbidity and mortality. Chronic inflammation plays a crucial role in the pathogenesis of thrombotic events in patients with IBD. However, many unresolved questions remain, particularly regarding the mechanisms that determine the persistent inflammatory state independent of disease activity. This review explored the role of gut microbiota dysbiosis and intestinal barrier dysfunction, which are considered distinctive features of IBD, in determining pro-thrombotic tendencies. (...
Source: Thrombosis Research - November 5, 2023 Category: Hematology Authors: Alfredo Papa, Paolo Santini, Sara Sofia De Lucia, Rossella Maresca, Angelo Porfidia, Pasquale Pignatelli, Antonio Gasbarrini, Francesco Violi, Roberto Pola Source Type: research
Editorial Board
(Source: Thrombosis Research)
Source: Thrombosis Research - November 1, 2023 Category: Hematology Source Type: research
Low-grade endotoxemia in acute pulmonary embolism: Links with prothrombotic plasma fibrin clot phenotype
Lipopolysaccharide (LPS) can traverse the intestinal barrier and enter bloodstream, causing endotoxemia and triggering inflammation. Increased circulating LPS were reported in arterial thromboembolism. We investigated whether increased LPS occur in acute pulmonary embolism (PE) and if it is associated with a prothrombotic state. (Source: Thrombosis Research)
Source: Thrombosis Research - October 31, 2023 Category: Hematology Authors: Micha ł Ząbczyk, Aleksandra Kruk, Joanna Natorska, Anetta Undas Tags: Full Length Article Source Type: research
