The impact of renal function on clinical outcomes of patients with cancer-associated isolated distal deep vein thrombosis: Insights from the ONCO DVT study
The multicenter, open-label, randomized clinical trial ONCO DVT compared 3-month and 12-month edoxaban treatment regimens for isolated distal deep vein thrombosis (DVT) and suggested potential benefits of prolonged edoxaban treatment in terms of thrombotic risk. However, the risk-benefit balance of prolonged edoxaban treatment in patients with renal function remains unclear. (Source: Thrombosis Research)
Source: Thrombosis Research - February 2, 2024 Category: Hematology Authors: Daisuke Sueta, Yugo Yamashita, Takeshi Morimoto, Nao Muraoka, Michihisa Umetsu, Yuji Nishimoto, Takuma Takada, Yoshito Ogihara, Tatsuya Nishikawa, Nobutaka Ikeda, Kazunori Otsui, Yukari Tsubata, Masaaki Shoji, Ayumi Shikama, Yutaka Hosoi, Yasuhiro Tanabe, Tags: Full Length Article Source Type: research
The search for the underlying mutations causing VWD in 13 Venezuelan families
Von Willebrand disease (VWD) is the most common inherited bleeding disorder due to quantitative or qualitative deficiencies of von Willebrand factor (VWF). Six main types of VWD have been described [1]. Relative quantitative deficiencies of functionally normal VWF (VWF levels 0.7) correspond to type 1 (OMIM ID #193400) with dominant inheritance, or complete deficiency to severe VWD type 3 (OMIM ID #277480), with recessive inheritance (VWF:Ag (Source: Thrombosis Research)
Source: Thrombosis Research - January 31, 2024 Category: Hematology Authors: Rita Marchi, Tobias Obser, Florian Oyen, Arlette Ruiz-S áez, Apsara Boadas, Marion Echenagucia, Sonja Schneppenheim, Ulrich Budde, Reinhard Schneppenheim Tags: Letter to the Editors-in-Chief Source Type: research
Incidence and risk factors of post-thrombotic syndrome in patients with isolated calf vein thrombosis. Findings from the GARFIELD-VTE registry
In contrast with extensive information on the risk of post-thrombotic syndrome (PTS) in patients with proximal deep vein thrombosis (DVT) of the lower extremities [1], little is known for patients with isolated distal DVT (IDDVT), which is expected to account for approximately one third of all DVTs of the lower extremities [2]. The heterogeneity of available studies, the variability of initial and long-term treatment, the variable duration of follow-up, the different study modalities, and the lack of standardization of criteria used for PTS assessment virtually preclude a reliable quantification of PTS rate and severity, w...
Source: Thrombosis Research - January 31, 2024 Category: Hematology Authors: Paolo Prandoni, Sylvia Haas, Meg Fluharty, Sebastian Schellong, Shinya Goto, Peter MacCallum, Eric Tse, Karen Pieper, Gloria Kayani, Ajay Kakkar, GARFIELD-VTE investigators Tags: Letter to the Editors-in-Chief Source Type: research
Editorial Board
(Source: Thrombosis Research)
Source: Thrombosis Research - January 30, 2024 Category: Hematology Source Type: research
Disordered gut microbiota and alterations in the serum metabolome are associated with venous thromboembolism
The gut microbiome plays a crucial role in various diseases, and its regulation is a potential treatment option for these conditions. However, the relationship between the gut microbiome and venous thromboembolism (VTE) remains poorly explored. (Source: Thrombosis Research)
Source: Thrombosis Research - January 28, 2024 Category: Hematology Authors: Zeqin Fan, Shuanglan Xu, Yishu Deng, Li Wei, Jiao Yang, Xiqian Xing Tags: Full Length Article Source Type: research
Outpatient management of cancer-associated pulmonary embolism: A post-hoc analysis from the HOME-PE trial
Cancer-related pulmonary embolism (PE) is associated with poor prognosis. Some decision rules identifying patients eligible for home treatment categorize cancer patients at high risk of complications, precluding home treatment. We sought to assess the effectiveness and the safety of outpatient management of patients with low-risk cancer-associated PE. (Source: Thrombosis Research)
Source: Thrombosis Research - January 25, 2024 Category: Hematology Authors: S érine Chaibi, Pierre-Marie Roy, Armelle Arnoux Guénégou, Yohann Tran, Olivier Hugli, Andréa Penaloza, Francis Couturaud, Cécile Tromeur, Tali-Anne Szwebel, Gilles Pernod, Antoine Elias, Alexandre Ghuysen, Ygal Benhamou, Nicolas Falvo, Henry Juchet, Tags: Full Length Article Source Type: research
Activated protein C and free protein S in patients with mild to moderate bleeding disorders
Underlying mechanisms for bleeding and impaired thrombin generation (TG) and plasma clot formation (PCF) in patients with mild to moderate bleeding disorders (MBDs) are still to be elucidated, especially in bleeding disorder of unknown cause (BDUC). The role of the natural anticoagulants activated protein C (APC) and free protein S (PS) has not yet been investigated in this patient population. (Source: Thrombosis Research)
Source: Thrombosis Research - January 25, 2024 Category: Hematology Authors: Dino Mehic, Theresa Schramm, Birgit Forstner-Bergauer, Helmuth Haslacher, Cihan Ay, Ingrid Pabinger, Johanna Gebhart Tags: Full Length Article Source Type: research
Risk of thromboembolism according to statin treatment in patients with cancer: A nationwide nested case-control study
Background: Thromboembolic events exhibit increased prevalence in patients with cancer and can negatively affect prognoses. We investigated whether statin treatment would reduce thromboembolic risk in patients with cancer.Methods: We conducted a nested case-control study using a Korean nationwide health claims database. The study included patients newly diagnosed with cancer without a prior history of cardiovascular disease between 2014 and 2016. Cases who developed arterial thromboembolism (ATE) or venous thromboembolism (VTE) after cancer diagnosis and three individually matched controls were selected. (Source: Thrombosis Research)
Source: Thrombosis Research - January 24, 2024 Category: Hematology Authors: Joonsang Yoo, Jimin Jeon, Minyoul Baik, Jinkwon Kim Tags: Full Length Article Source Type: research
A comparative in vitro study of the anticoagulant effect of branded versus generic rivaroxaban
Several generic formulations of rivaroxaban were recently marketed to be used interchangeably with their branded equivalent. However, there have been no previously published studies that directly compared the in vitro anticoagulant effect of branded vs. generic rivaroxaban. The aim of this in vitro study was to compare the effects of three raw rivaroxaban materials, obtained from the branded (Xarelto ®) and two generic (Rivarolto® and Rivaroxaban Sandoz®) rivaroxaban formulations on an array of coagulation assays. (Source: Thrombosis Research)
Source: Thrombosis Research - January 23, 2024 Category: Hematology Authors: Karl Mangion, Kevin Vella, Alex Gatt, Amy Marie Vella, Marica Borg, Denise Borg-Aquilina, Jonathan Douxfils, Liberato Camilleri, Nicoletta Riva Tags: Full Length Article Source Type: research
Anticoagulation in cancer patients with atrial fibrillation and grade 3 –4 thrombocytopenia
Atrial fibrillation or flutter (AF) is prevalent in cancer patients. Many of these patients have an indication for anticoagulation (AC) but are also at risk for developing chemotherapy-induced thrombocytopenia. There are scarce data regarding management of AC and risk of bleeding and thrombosis in cancer patients with AF and thrombocytopenia. (Source: Thrombosis Research)
Source: Thrombosis Research - January 22, 2024 Category: Hematology Authors: Genady Drozdinsky, Noam Arad, Galia Spectre, Nir Livneh, Itamar Poran, Pia Raanani, Anna Falanga, Hugo ten Cate, Anat Gafter-Gvili, Avi Leader Source Type: research
Analysis of NETs (neutrophil extracellular traps) in coronary thrombus and peripheral blood of patients with ST-segment elevation myocardial infarction
Neutrophil extracellular traps (NETs) are modified chromatin structures extruded by neutrophils in response to specific stimuli, bound to cytoplasmic and granular proteins. Apart from a protective role against pathogens, NETs may exhibit potent proinflammatory and prothrombotic properties when dysregulated. NETs have been found in coronary thrombi and seem to be deleterious in this clinical setting; NET burden has been associated with infarct size directly [1] and with unfavorable short-term prognosis in patients with ST-segment elevation myocardial infarction (STEMI) [2,3]. (Source: Thrombosis Research)
Source: Thrombosis Research - January 20, 2024 Category: Hematology Authors: Ana Blasco, Axel Rosell, Raquel Castej ón, María-José Coronado, Ana Royuela, Elvira Ramil, Silvia Elorza, Charlotte Thålin, Paloma Martín, Basilio Angulo, Beatriz Rascón, Sergio García-Gómez, Inuntze Zabala, Javier Ortega, Lorenzo Silva, Carmen Be Tags: Letter to the Editors-in-Chief Source Type: research
External validation of the PE-SARD risk score for predicting early bleeding in acute pulmonary embolism in the RIETE Registry
The PE-SARD score (syncope, anemia, renal dysfunction) was developed to predict the risk of major bleeding in the acute phase of pulmonary embolism (PE). (Source: Thrombosis Research)
Source: Thrombosis Research - January 20, 2024 Category: Hematology Authors: Romain Chopard, Laurent Bertoletti, Gregory Piazza, David Jimenez, Giovanni Barillari, Pilar Llamas, Carmen M ª. Rubio, Avinash Aujayeb, Manuel Monreal, Nicolas Meneveau Source Type: research
Pharmacokinetics of direct oral anticoagulants after bariatric surgery: A retrospective cohort study
Bariatric surgery is being used with increasing frequency to prevent and treat health complications associated with obesity [1]. Patients who have undergone bariatric surgery may require oral anticoagulation because bariatric surgery itself confers an increased risk of peri-operative VTE and obesity is an independent risk factor for developing atrial fibrillation [2,3]. (Source: Thrombosis Research)
Source: Thrombosis Research - January 17, 2024 Category: Hematology Authors: Barbara Gunka, Danielle Mackenzie, Taylor Hughes, Laurie Sardo, Julia Bayadinova, Deborah M. Siegal, Eric K. Tseng, Aristithes G. Doumouras, Siraj Mithoowani Tags: Letter to the Editors-in-Chief Source Type: research
TRanEXamic acid to decrease heavy menstrual bleeding in individuals anticoagulated for venous thromboembolism (T-REX HMB): Health care practitioner survey
Heavy menstrual bleeding (HMB) is a complication of anticoagulation in individuals with venous thromboembolism (VTE), and is associated with iron deficiency, anemia, decreased quality of life and high demands on health care utilization [1,2]. In non-anticoagulated individuals, oral tranexamic acid (TXA) reduces menstrual blood loss by half per cycle, but no data exists for the use of TXA in anticoagulated individuals [3]. Despite TXA's potential in reducing HMB, it was historically contraindicated in those with VTE due to concern that as an antifibrinolytic agent, it may increase the risk of recurrent thrombosis [4]. (Sour...
Source: Thrombosis Research - January 16, 2024 Category: Hematology Authors: Jameel Abdulrehman, Amye Harrigan, Camille Simard, Vicky Tagalakis, Sudeep Shivakumar Tags: Letter to the Editors-in-Chief Source Type: research
Performance-based outcome measures for assessing physical capacity in patients with pulmonary embolism: A scoping review
Up to 50 % of patients surviving a pulmonary embolism (PE) report persisting shortness of breath, reduced physical capacity and psychological distress. As the PE population is heterogeneous compared to other cardiovascular patient groups, outcome measures for assessing physical capacity traditionally used in cardiac populations may not be reliable for the PE population as a whole. This scoping review aims to 1) map performance-based outcome measures (PBOMs) used for assessing physical capacity in PE research, and 2) to report the psychometric properties of the identified PBOMs in a PE population. (Source: Thrombosis Research)
Source: Thrombosis Research - January 15, 2024 Category: Hematology Authors: Christina Krogner Caspersen, Stian Ingemann-Molden, Erik Lerkevang Grove, Anette Arbjerg H øjen, Jane Andreasen, Frederikus A. Klok, Nanna Rolving Tags: Review Article Source Type: research
