Acute phase determinant of post-thrombotic syndrome: A review of the literature
Post-thrombotic syndrome (PTS) is the main long-term complication of deep vein thrombosis (DVT). Several therapies are being evaluated to prevent or to treat PTS. Identifying the patients most likely to benefit from these therapies presents a significant challenge. (Source: Thrombosis Research)
Source: Thrombosis Research - April 11, 2024 Category: Hematology Authors: Lina Khider, Benjamin Planquette, David Smadja, Olivier Sanchez, Carla Rial, Guillaume Goudot, Emmanuel Messas, Tristan Mirault, Nicolas Gendron Tags: Review Article Source Type: research
Small intestinal angiodysplasia and hemorrhage associated with acquired von Willebrand syndrome type 2A secondary to multiple myeloma: Reversal after treatment with IRD regimen (a case report and a brief review of the literature)
Acquired von Willebrand syndrome (AVWS) is a rare acquired hemorrhagic disorder, characterized by qualitative or quantitative deficiencies in von Willebrand factor (VWF), which is easily misdiagnosed as a genetic von Willebrand disease (VWD) and probably underdiagnosed [1,2]. Usually, the diagnosis of AVWS is complicated, and both clinical and case history evaluation as well as laboratory results are required for discerning AVWS from inherited VWD [2,3]. Here we report a case of AVWS secondary to IgA-kappa type of multiple myeloma (MM), found that the existence of anti-VWF autoantibodies (IgG type) in plasma may contribute...
Source: Thrombosis Research - April 11, 2024 Category: Hematology Authors: Yuxin Zhang, Xuquan Zhou, Yujie Guo, Yongning Gao, Zhiyun Niu, Yi Wu, Yan Wang, Jingyu Zhang Tags: Letter to the Editors-in-Chief Source Type: research
In-depth structure-function profiling of the complex formation between clotting factor VIII and heme
Blood disorders, such as sickle cell disease, and other clinical conditions are often accompanied by intravascular hemolytic events along with the development of severe coagulopathies. Hemolysis, in turn, leads to the accumulation of Fe(II/III)-protoporphyrin IX (heme) in the intravascular compartment, which can trigger a variety of proinflammatory and prothrombotic reactions. As such, heme binding to the blood coagulation proteins factor VIII (FVIII), fibrinogen, and activated protein C with functional consequences has been demonstrated earlier. (Source: Thrombosis Research)
Source: Thrombosis Research - April 11, 2024 Category: Hematology Authors: Marie-T. Hopp, Deniz Ugurlar, Behnaz Pezeshkpoor, Arijit Biswas, Anuradha Ramoji, Ute Neugebauer, Johannes Oldenburg, Diana Imhof Tags: Full Length Article Source Type: research
Is there a role for the laboratory monitoring in the management of specific antidotes of direct oral anticoagulants?
Given the growing number of patients receiving direct oral anticoagulant (DOAC), patients requiring rapid neutralization is also increasing in case of major bleedings or urgent surgery/procedures. Idarucizumab is commercialized as a specific antidote to dabigatran while andexanet alfa has gained the Food and Drug Administration and the European Medicines Agency approval as an oral anti-factor Xa inhibitors antidote. Other antidotes or hemostatic agents are still under preclinical or clinical development, the most advanced being ciraparantag. (Source: Thrombosis Research)
Source: Thrombosis Research - April 9, 2024 Category: Hematology Authors: Nicolas Gendron, Paul Billoir, Virginie Siguret, V éronique Le Cam-Duchez, Valérie Proulle, Laurent Macchi, Elodie Boissier, Christine Mouton, Emmanuel De Maistre, Isabelle Gouin-Thibault, Georges Jourdi, French Society on Thrombosis and Haemostasis Source Type: research
Potential treatment option of rivaroxaban for breastfeeding women: A case series
The use of direct oral anticoagulants (DOACs) in breastfeeding women is currently challenging due to limited safety data for breastfeeding infants, and there have been no previous studies on the drug concentration in breastfeeding infants. We treated 2 patients (one case was twin pregnancy) with venous thromboembolisms in breastfeeding women administered rivaroxaban at our institution. Blood samples from the mothers and breastmilk samples were collected at time 0 and 2 h after the rivaroxaban administration, breastfeeding was conducted 2 h after the rivaroxaban administration, and blood samples from the infants were c...
Source: Thrombosis Research - April 4, 2024 Category: Hematology Authors: Yugo Yamashita, Daiki Hira, Makiko Morita, Yurie Katsube, Masahito Takakura, Hiroko Tomotaki, Seiichi Tomotaki, Wei Xiong, Hiroki Shiomi, Takahiro Horie, Satoshi Ueshima, Tomoyuki Mizuno, Tomohiro Terada, Koh Ono Tags: Letter to the Editors-in-Chief Source Type: research
Apixaban for the treatment of acute splanchnic vein thrombosis: A pilot study
Splanchnic vein thrombosis (SVT) refers to portal, mesenteric, splenic vein thrombosis, or Budd-Chiari syndrome [1]. Liver cirrhosis (LC) and malignancy are leading risk factors of SVT, although various medical conditions, including myeloproliferative disease, inflammation, and surgery, can contribute to SVT development [2]. (Source: Thrombosis Research)
Source: Thrombosis Research - April 3, 2024 Category: Hematology Authors: Sang-A Kim, Gwang Hyeon Choi, Ji Yun Lee, Eun Sun Jang, Jeong-Ok Lee, Jin-Wook Kim, Sook-Hyang Jeong, Soo-Mee Bang Tags: Letter to the Editors-in-Chief Source Type: research
Modest performance of risk-prediction models for anticoagulant-related bleeding in patients with chronic liver disease
Patients with chronic liver disease (CLD) have a precarious hemostatic balance that can easily tip towards thrombosis or bleeding. These patients experience a higher risk of stroke [1], splanchnic vein thrombosis [2] and venous thromboembolism (i.e., deep venous thrombosis and pulmonary embolism) [3] than patients without liver disease. Liver disease also doubles the risk of anticoagulant-related bleeding [4]. As liver disease progresses, the risk of bleeding rises: one in three individuals with Child-Pugh B and C cirrhosis have bleeding with use of anticoagulant therapy [5]. (Source: Thrombosis Research)
Source: Thrombosis Research - April 3, 2024 Category: Hematology Authors: Amber Afzal, Brian F. Gage, Luo Suhong, Martin Schoen, Kristen M. Sanfilippo Tags: Letter to the Editors-in-Chief Source Type: research
Association between perioperative red blood cell transfusions and postoperative venous thromboembolism: A systematic review and meta-analysis
Whether perioperative red blood cell transfusions increases the risk of postoperative venous thromboembolism is controversial and uncertain.We aims to explore the relationship between perioperative red blood cell transfusions and the risk of postoperative venous thromboembolism by conducting a meta-analysis. (Source: Thrombosis Research)
Source: Thrombosis Research - April 2, 2024 Category: Hematology Authors: Mengyan Mo, Zerong Lian, Yongyan Xiang, Xiaogang Du, Hua Liu, Jie Sun, Rui Wang Tags: Full Length Article Source Type: research
Immature platelets and platelet reactivity in patients with acute ST-segment Elevation Myocardial Infarction using whole blood flow cytometry with SYTO-13 staining
Reduced effect of antiplatelet therapy has been reported in patients with ST-segment elevation myocardial infarction (STEMI). Multiple factors may concur to explain this, including increased amount of highly reactive immature platelets. (Source: Thrombosis Research)
Source: Thrombosis Research - March 31, 2024 Category: Hematology Authors: Oliver Buchhave Pedersen, Anne-Mette Hvas, Peter H. Nissen, Leonardo Pasalic, Steen Dalby Kristensen, Erik Lerkevang Grove Tags: Full Length Article Source Type: research
The emicizumab-bridged ternary complex with activated factor IX and factor X evaluated by fluorescence resonance energy transfer
Activated factor VIII (FVIIIa) functions as a cofactor for FIXa in the tenase complex responsible for phospholipid (PL) surface-dependent conversion of FX to FXa [1]. FVIII is processed into a metal ion-dependent heterodimer, consisting of a heavy chain (HCh) composed of the A1 and A2 domains, and a partially proteolyzed B domain, linked to a light chain (LCh) composed of the A3, C1, and C2 domains [2]. The FVIIIa molecule has multiple contact-extended surfaces with both FIXa and FX molecules [3]. (Source: Thrombosis Research)
Source: Thrombosis Research - March 31, 2024 Category: Hematology Authors: Akihisa Oda, Masahiro Takeyama, Takehisa Kitazawa, Keiji Nogami Tags: Letter to the Editors-in-Chief Source Type: research
Acute pulmonary embolism in cancer patients admitted to intensive care unit: Impact of anticoagulant treatment on 90-day mortality and risk factors, results of a multicentre retrospective study
Acute pulmonary embolism (PE) is a life-threatening situation in cancer patients. In this situation, anticoagulant therapy is complex to administer due to the risk of bleeding. Only few studies have been conducted when these patients are admitted to the intensive care unit (ICU). The aim of this study was to assess the association between anticoagulation strategies as well as other factors with 90-day mortality in patients with cancer and PE admitted to ICU. Major bleeding was also evaluated according to the type of anticoagulation. (Source: Thrombosis Research)
Source: Thrombosis Research - March 31, 2024 Category: Hematology Authors: Djamel Mokart, Edouard Serre, Fabrice Bruneel, Achille Kouatchet, Virginie Lemiale, Laurent Chow-Chine, Marion Faucher, Antoine Sannini, Sandrine Valade, Magali Bisbal, Frederic Gonzalez, Luca Servan, Micha ël Darmon, Elie Azoulay Tags: Full Length Article Source Type: research
Exploring the effects of Factor Xa inhibitors on thrombin generation in people with haemophilia
Optimal management of cardiovascular disease (CVD) in people with haemophilia (PWH) is a growing issue, given the continuing improvement in life expectancy among PWH. The evolving treatment paradigms targeting higher trough levels and the advent of non-factor replacement therapies (NFRT) means much of the ‘protection’ PWH were thought to have against CVD may be lost. There is a paucity of evidence regarding the safety of using anticoagulants in PWH. We designed a study assessing the thrombin generation (TG) of PWH of different severities and treatments, compared to non-haemophilia patients receiv ing a Factor Xa (FXa) ...
Source: Thrombosis Research - March 29, 2024 Category: Hematology Authors: Caroline Dix, James D. McFadyen, Huyen A. Tran Tags: Full Length Article Source Type: research
Identification of thrombosis-related conformational binding epitopes on domain I of β2-glycoprotein I
The identification of epitopes that react with pathogenic antibodies is essential in the understanding of the pathogenesis of autoimmune diseases and optimize tailored treatment. The antiphospholipid syndrome (APS) is an autoimmune disease with thrombosis and pregnancy morbidity as main clinical symptoms, and the persistent presence of so-called antiphospholipid antibodies (aPL) as laboratory criteria [1]. Given the high incidence of clinical criteria irrespective of APS, diagnosis depends largely on laboratory criteria, defined as lupus anticoagulant (LA) and/or anti-cardiolipin (aCL) and/or anti- β2glycoprotein I (aβ2G...
Source: Thrombosis Research - March 28, 2024 Category: Hematology Authors: Seung Joong Kim, Dina Schneidman-Duhovny, Philip G. de Groot, Rolf T. Urbanus, Lester Carter, Romy de Laat-Kremers, Thomas M. Weiss, Man K. Chan, Andrej Sali, Jacob H. Rand, Bas De Laat Tags: Letter to the Editors-in-Chief Source Type: research
Translatability of point-of-care D-dimers
This research was supported (in whole or in part) by HCA Healthcare and/or an HCA Healthcare affiliated entity. The views expressed in this publication represent those of the author(s) and do not necessarily represent the official views of HCA Healthcare or any of its affiliated entities. (Source: Thrombosis Research)
Source: Thrombosis Research - March 28, 2024 Category: Hematology Authors: Murtaza Akhter Tags: Letter to the Editors-in-Chief Source Type: research
Editorial Board
(Source: Thrombosis Research)
Source: Thrombosis Research - March 27, 2024 Category: Hematology Source Type: research
