Immature platelet dynamics in management of protracted response to therapy of a young pediatric patient with immune-mediated thrombotic thrombocytopenic purpura
Immune-mediated thrombotic thrombocytopenic purpura (iTTP) represents an emergent clinical presentation that can lead to significant morbidity and potentially mortality if left untreated. Diagnosis of iTTP is dependent upon establishing deficiency in the enzyme ADAMTS13 ( ≤10 %), that in most cases is due to autoantibody formation [1]. These inhibitory autoantibodies prevent ADAMTS13 function leading to accumulation of ultra-large molecular weight von Willebrand Factor multimers, diffuse microvascular thrombi formation and consequently severe thrombocytopenia [2] . (Source: Thrombosis Research)
Source: Thrombosis Research - June 3, 2023 Category: Hematology Authors: Robert W. Maitta, Hollie M. Reeves, Katharine A. Downes, Xiangrong He, Lisa R. Hackney, Sanjay P. Ahuja Tags: Letter to the Editors-in-Chief Source Type: research
Clinical effectiveness and safety of edoxaban in obese patients — Results of the prospective Dresden NOAC Registry (NCT01588119)
Edoxaban is a direct factor Xa inhibitors approved for stroke prevention in atrial fibrillation (SPAF) and for venous thromboembolism (VTE) treatment. Edoxaban is given in a fixed dosing regimen (with recommended dose reductions for patients with renal impairment or body weight (Source: Thrombosis Research)
Source: Thrombosis Research - June 2, 2023 Category: Hematology Authors: Luise Tittl, Christina K öhler, Sandra Marten, Christiane Naue, Kristina Fache, Laura Stanneck, Thomas Schreier, Jan Beyer-Westendorf Tags: Letter to the Editors-in-Chief Source Type: research
Editorial Board
(Source: Thrombosis Research)
Source: Thrombosis Research - June 1, 2023 Category: Hematology Source Type: research
The international normalised ratio to monitor coagulation factor production during normothermic machine perfusion of human donor livers
Normothermic machine perfusion (NMP) of donor livers allows for new diagnostic and therapeutic strategies. As the liver produces most of the haemostatic proteins, coagulation assays such as the International Normalised Ratio (INR) performed in perfusate may be useful to assess hepatocellular function of donor livers undergoing NMP. However, high concentrations of heparin and low levels of fibrinogen may affect coagulation assays. (Source: Thrombosis Research)
Source: Thrombosis Research - May 31, 2023 Category: Hematology Authors: Bente P. van den Boom, Silke B. Bodewes, Bianca Lascaris, Jelle Adelmeijer, Robert J. Porte, Vincent E. de Meijer, Ton Lisman Tags: Full Length Article Source Type: research
Idarucizumab for dabigatran reversal: A systematic review and meta-analysis of indications and outcomes
Idarucizumab has been approved to reverse the anticoagulant effect of dabigatran. However, there is little knowledge of the effectiveness and safety of idarucizumab in daily practice. (Source: Thrombosis Research)
Source: Thrombosis Research - May 29, 2023 Category: Hematology Authors: S.F.B. van der Horst, E.S.L. Martens, P.L. den Exter, M.H.A. Bos, T.E. van Mens, M.V. Huisman, F.A. Klok Tags: Review Article Source Type: research
Major cardiovascular events after COVID-19, event rates post-vaccination, antiviral or anti-inflammatory therapy, and temporal trends: Rationale and methodology of the CORONA-VTE-Network study
Coronavirus disease 2019 (COVID-19) is associated with excess risk of cardiovascular and thrombotic events in the early post-infection period and during convalescence. Despite the progress in our understanding of cardiovascular complications, uncertainty persists with respect to more recent event rates, temporal trends, association between vaccination status and outcomes, and findings within vulnerable subgroups such as older adults (aged 65 years or older), or those undergoing hemodialysis. Sex-informed findings, including results among pregnant and breastfeeding women, as well as adjusted comparisons between male and ...
Source: Thrombosis Research - May 29, 2023 Category: Hematology Authors: Behnood Bikdeli, Candrika D. Khairani, Darsiya Krishnathasan, Antoine Bejjani, Andre Armero, Anthony Tristani, Julia Davies, Nicole Porio, Ali A. Assi, Victor Nauffal, Umberto Campia, Zaid Almarzooq, Eric Wei, Aditya Achanta, Sirus J. Jesudasen, Bruce C. Tags: Full Length Article Source Type: research
Effect of the P-glycoprotein inhibitor tamoxifen on edoxaban plasma levels in women with breast cancer
Concomitant use of P-glycoprotein inhibitors can reduce clearance of edoxaban and increase its plasma concentration. Caution is advised with simultaneous use of edoxaban and the frequently used P-glycoprotein inhibitor tamoxifen. However, pharmacokinetic data are lacking. (Source: Thrombosis Research)
Source: Thrombosis Research - May 29, 2023 Category: Hematology Authors: Floris Bosch, Frits Mulder, Linda Franken, Annelieke Willemsen, Marjolein Rentinck, Pieter van den Berg, Sylvia Luykx-de Bakker, Ankie van der Velden, Nick van Es, Ron Math ôt, Pieter W. Kamphuisen Tags: Full Length Article Source Type: research
Use of ecarin chromogenic assay during bivalirudin anticoagulation in adult extracorporeal membrane oxygenation
Bivalirudin directly inhibits clot-bound and circulating thrombin without requiring cofactors, has a short half-life, and lacks immunogenicity, making it an attractive anticoagulant over heparin during extracorporeal membrane oxygenation (ECMO) [1]. Empirical evidence demonstrates a favorable safety and efficacy profile of bivalirudin, and that it may result in increased time in therapeutic range compared to heparin during ECMO [2]. However, an assay that reliably quantifies bivalirudin anticoagulant effect is critical in preventing thrombus deposition and minimizing bleeding complications during the high stakes' context o...
Source: Thrombosis Research - May 29, 2023 Category: Hematology Authors: Abby K. Krauter, Scott D. Nei, Troy G. Seelhammer, J. Kyle Bohman, Patrick M. Wieruszewski Tags: Letter to the Editors-in-Chief Source Type: research
A novel role of acellular hemoglobin in hemolytic thrombosis
In this study, we examined the interaction between hemoglobin and the A1 domain of von Willebrand factor (VWF), which is a critical mediator of platelet activation. (Source: Thrombosis Research)
Source: Thrombosis Research - May 29, 2023 Category: Hematology Authors: Yan Wan, Yaxuan Wei, Canhe Zhang, Yuanyuan Liu, Linru Xu, Chengyuan Gu, Ziqiang Yu, Jie Yin, Qing Zhang, Wei Deng Tags: Full Length Article Source Type: research
Implementation of CYP2C19 genotyping and clinical outcomes following percutaneous coronary intervention in East Asian patients treated with oral P2Y12 inhibitors
The CYP2C19 loss-of-function variants have significant impact on response to clopidogrel. The efficacy and safety of tailored antiplatelet therapy under the guidance of CYP2C19 genetic polymorphisms remains elusive for patients undergoing percutaneous coronary intervention (PCI). (Source: Thrombosis Research)
Source: Thrombosis Research - May 29, 2023 Category: Hematology Authors: Ziwei Xi, Yong Wang, Qianhong Lu, Hong Qiu, Yanan Gao, Ang Gao, Runlin Gao Tags: Full Length Article Source Type: research
Arterial events in cancer patients treated with apixaban for venous thrombosis
In a recent interventional study of cancer patients with newly diagnosed venous thrombosis (VT), we found a high risk of arterial thrombotic events (AT) during treatment with therapeutic doses of apixaban. (Source: Thrombosis Research)
Source: Thrombosis Research - May 24, 2023 Category: Hematology Authors: Trine-Lise Larsen, Marte Svalastoga, Jorunn Brekke, Tone Enden, Hege Fr øen, Herish Garresori, Eva Marie Jacobsen, Petter Quist Paulsen, Alina Carmen Porojnicu, Anne Hansen Ree, Dag Torfoss, Elin Osvik Velle, Hilde Skuterud Wik, Waleed Ghanima, Per Morte Tags: Full Length Article Source Type: research
Tissue factor expression in monocyte subsets during human immunothrombosis, endotoxemia and sepsis
Tissue factor expression on monocytes is implicated in the pathophysiology of sepsis-induced coagulopathy. How tissue factor is expressed by monocyte subsets (classical, intermediate and non-classical) is unknown. (Source: Thrombosis Research)
Source: Thrombosis Research - May 24, 2023 Category: Hematology Authors: Kathryn M. Musgrave, Jonathan Scott, Wezi Sendama, Aaron I. Gardner, Fiona Dewar, Cameron J. Lake, Henri M.H. Spronk, Rene van Oerle, Mayken Visser, Hugo ten Cate, Patrick Kesteven, Andrew Fuller, David McDonald, Carly Knill, Gillian Hulme, Andrew Filby, Tags: Full Length Article Source Type: research
Unexplained fetal death, pre-eclampsia and fetal growth restriction in pregnancy: Who is screened for antiphospholipid syndrome?
Antiphospholipid syndrome (APS) is defined by thrombosis or pregnancy morbidity associated with persistent antiphospholipid autoantibodies (aPL) namely, lupus anticoagulant (LA) and/or IgG/IgM anticardiolipin antibodies (aCL) and/or IgG/IgM anti- β2glycoprotein-1 (aβ2GPI) [1]. (Source: Thrombosis Research)
Source: Thrombosis Research - May 24, 2023 Category: Hematology Authors: Clothilde Gros, Tiphaine Barral, Arthur Mageau, Pascale Roland Nicaise, Val érie Vivier, Thomas Papo, Agnès Bourgeois-Moine, Tiphaine Goulenok, Karim Sacre Tags: Letter to the Editors-in-Chief Source Type: research
Recovery-model: A model for CAR T-cell-related thrombocytopenia in relapsed/refractory multiple myeloma
Patients with multiple myeloma (MM) treated with anti-B cell maturation antigen (BCMA) and chimeric antigen receptor (CAR) T-cell therapy tend to show delayed platelet recovery. (Source: Thrombosis Research)
Source: Thrombosis Research - May 22, 2023 Category: Hematology Authors: Zhe Li, Yimei Que, Di Wang, Jie Lu, Chunhui Li, Menglei Xu, Zhiqiong Wang, Qiuxia Yu, Xiaolu Long, Ning An, Yi Xiao, Chunrui Li Tags: Full Length Article Source Type: research
Editorial Board
(Source: Thrombosis Research)
Source: Thrombosis Research - May 20, 2023 Category: Hematology Source Type: research
