Effect of the P-glycoprotein inhibitor tamoxifen on edoxaban plasma levels in women with breast cancer
Concomitant use of P-glycoprotein inhibitors can reduce clearance of edoxaban and increase its plasma concentration. Caution is advised with simultaneous use of edoxaban and the frequently used P-glycoprotein inhibitor tamoxifen. However, pharmacokinetic data are lacking.
Source: Thrombosis Research - Category: Hematology Authors: Floris Bosch, Frits Mulder, Linda Franken, Annelieke Willemsen, Marjolein Rentinck, Pieter van den Berg, Sylvia Luykx-de Bakker, Ankie van der Velden, Nick van Es, Ron Math ôt, Pieter W. Kamphuisen Tags: Full Length Article Source Type: research