Pharmacokinetics of direct oral anticoagulants after bariatric surgery: A retrospective cohort study
Bariatric surgery is being used with increasing frequency to prevent and treat health complications associated with obesity [1]. Patients who have undergone bariatric surgery may require oral anticoagulation because bariatric surgery itself confers an increased risk of peri-operative VTE and obesity is an independent risk factor for developing atrial fibrillation [2,3]. (Source: Thrombosis Research)
Source: Thrombosis Research - January 17, 2024 Category: Hematology Authors: Barbara Gunka, Danielle Mackenzie, Taylor Hughes, Laurie Sardo, Julia Bayadinova, Deborah M. Siegal, Eric K. Tseng, Aristithes G. Doumouras, Siraj Mithoowani Tags: Letter to the Editors-in-Chief Source Type: research
TRanEXamic acid to decrease heavy menstrual bleeding in individuals anticoagulated for venous thromboembolism (T-REX HMB): Health care practitioner survey
Heavy menstrual bleeding (HMB) is a complication of anticoagulation in individuals with venous thromboembolism (VTE), and is associated with iron deficiency, anemia, decreased quality of life and high demands on health care utilization [1,2]. In non-anticoagulated individuals, oral tranexamic acid (TXA) reduces menstrual blood loss by half per cycle, but no data exists for the use of TXA in anticoagulated individuals [3]. Despite TXA's potential in reducing HMB, it was historically contraindicated in those with VTE due to concern that as an antifibrinolytic agent, it may increase the risk of recurrent thrombosis [4]. (Sour...
Source: Thrombosis Research - January 16, 2024 Category: Hematology Authors: Jameel Abdulrehman, Amye Harrigan, Camille Simard, Vicky Tagalakis, Sudeep Shivakumar Tags: Letter to the Editors-in-Chief Source Type: research
Performance-based outcome measures for assessing physical capacity in patients with pulmonary embolism: A scoping review
Up to 50 % of patients surviving a pulmonary embolism (PE) report persisting shortness of breath, reduced physical capacity and psychological distress. As the PE population is heterogeneous compared to other cardiovascular patient groups, outcome measures for assessing physical capacity traditionally used in cardiac populations may not be reliable for the PE population as a whole. This scoping review aims to 1) map performance-based outcome measures (PBOMs) used for assessing physical capacity in PE research, and 2) to report the psychometric properties of the identified PBOMs in a PE population. (Source: Thrombosis Research)
Source: Thrombosis Research - January 15, 2024 Category: Hematology Authors: Christina Krogner Caspersen, Stian Ingemann-Molden, Erik Lerkevang Grove, Anette Arbjerg H øjen, Jane Andreasen, Frederikus A. Klok, Nanna Rolving Tags: Review Article Source Type: research
Percutaneous mesocaval shunt creation for portal thrombosis in a patient with a JAK2V617F mutation
Myeloproliferative neoplasms (MPN) are the most common cause of noncirrhotic, nontumoral portal vein thrombosis (PVT). Over 90 % of MPN patients with PVT carry the JAK2V617F mutation. Compared to other etiologies of PVT, patients with JAK2V617F MPNs are at increased risk of developing significant portal hypertension. However, when these patients develop refractory portal hypertensive complications requiring portosystemic shunt placement, they have limited options. Transjugular intrahepatic portosystemic shunt (TIPS) insertion is often not feasible, as these patients tend to have extensive, occlusive portal thrombus with...
Source: Thrombosis Research - January 15, 2024 Category: Hematology Authors: Ahmed Farhan, Robert P. Liddell Tags: Letter to the Editors-in-Chief Source Type: research
Differential regulation of human thrombospondin-1 upon systemic desmopressin versus endotoxin challenge
Von Willebrand factor (vWF) and thrombospondin-1 (TSP-1) are glycoproteins with procoagulant and prothrombotic properties, playing additional roles in inflammation and cell adhesion [1,2]. They are stored in granules of platelets and endothelial cells (ECs) and are released upon cell activation by agonists like lipopolysaccharide (LPS) or desmopressin [1,2]. In vivo changes in blood concentrations of vWF have previously been studied in human models of desmopressin or low-dose LPS administration to healthy volunteers [3 –5], while little is known about the time course of TSP-1 plasma concentrations in these settings [6]. ...
Source: Thrombosis Research - January 15, 2024 Category: Hematology Authors: Andreas Scheuba, Branislav Zagrapan, Luca Martelanz, Vanessa Eder, Nahla Ibrahim, Sonja Bleichert, Viktoria Kn öbl, Hubert Hayden, Sarah von Kuenheim, Katharina Münch, Nina Buchtele, Christian Schoergenhofer, Katarina D. Kovacevic, Edith Lackner, Christ Tags: Letter to the Editors-in-Chief Source Type: research
Late venous thromboembolism in survivors of adolescent and young adult cancer: A population-based study in California
Venous thromboembolism (VTE), a common complication in cancer patients, occurs more often during the initial phase of treatment. However, information on VTE beyond the first two years after diagnosis ( ‘late VTE’) is scarce, particularly in young survivors. (Source: Thrombosis Research)
Source: Thrombosis Research - January 14, 2024 Category: Hematology Authors: Renata Abrah ão, Ann Brunson, Jessica Chubak, Karen J. Wernli, Hazel B. Nichols, Chun Chao, Kathryn J. Ruddy, Erin E. Hahn, Qian Li, Marcio H. Malogolowkin, Candice A.M. Sauder, Lawrence H. Kushi, Ted Wun, Theresa H.M. Keegan Tags: Full Length Article Source Type: research
Exercise and hypoxia-induced hypercoagulability is counterbalanced in women in part by decreased platelet reactivity
In this study, we investigated the effect of gender and exercise on the coagulation potential under hypoxic conditions at high altitude by assessing thrombin generation (TG) and platelet activation. Hereto, ten healthy volunteers were included (50 % male, median age of 27.5 years). (Source: Thrombosis Research)
Source: Thrombosis Research - January 12, 2024 Category: Hematology Authors: M. Ninivaggi, F. Swieringa, H. Middelveld, V. Schmalschl äger, M. Roest, R. de Laat-Kremers, B. de Laat Tags: Full Length Article Source Type: research
Clinical prediction tool to identify children at risk of pulmonary embolism
This study aimed to create a PE predictive model and to evaluate the reported tools in the Thai pediatric population. (Source: Thrombosis Research)
Source: Thrombosis Research - January 12, 2024 Category: Hematology Authors: Tanatuch Tiratrakoonseree, Suwanat Charoenpichitnun, Rungrote Natesirinilkul, Natsaruth Songthawee, Patcharee Komvilaisak, Pongpak Pongphitcha, Jarin Vaewpanich, Nongnuch Sirachainan Source Type: research
COVID-19 infection and risk stratification for pulmonary embolism: Identifying optimal D-dimer thresholds
Elevated D-dimer values in patients with COVID-19 infection are a predictor of disease severity, mortality, and venous thromboembolism (VTE) [1,2]. Patients typically present with symptoms that overlap with symptoms of pulmonary emboli (PE) and the associated elevation of the D-dimer as a component of the inflammatory state raises unanswered questions regarding the diagnostic utility of D-dimer testing [3]. COVID-19 infection is a risk factor for PE and PE-related mortality [4], yet risk stratification tools such as the Wells', PERC, and Geneva risk scores have not been well-validated in this population [5]. (Source: Thrombosis Research)
Source: Thrombosis Research - January 11, 2024 Category: Hematology Authors: Damon E. Houghton, Ana I. Casanegra, Waldemar E. Wysokinski, Leslie J. Padrnos, Ewa Wysokinska, Rajiv Pruthi, Heather Heaton, Meera Sridharan, Robert D. McBane, Surbhi Shah Tags: Letter to the Editors-in-Chief Source Type: research
Intralesional pentraxin 3 increases with atherosclerotic disease progression, but may protect from thrombosis: Friend or foe?
To investigate the role of pentraxin 3 (PTX3) in atherosclerotic disease progression and plaque destabilization, as well as in coronary restenosis after directional coronary atherectomy (DCA). (Source: Thrombosis Research)
Source: Thrombosis Research - January 8, 2024 Category: Hematology Authors: Tomoyuki Otani, Sayaka Moriguchi-Goto, Kensaku Nishihira, Nobuyuki Oguri, Yoshisato Shibata, Yunosuke Matsuura, Tatsuhiko Kodama, Yujiro Asada, Kinta Hatakeyama, Atsushi Yamashita Source Type: research
Models for predicting venous thromboembolism in ambulatory patients with lung cancer: A systematic review and meta-analysis
The incidence of venous thromboembolism (VTE) in patients with lung cancer is relatively high, and risk stratification models are vital for the targeted application of thromboprophylaxis. We aimed to review VTE risk prediction models that have been developed in patients with lung cancer and evaluate their performance. (Source: Thrombosis Research)
Source: Thrombosis Research - January 6, 2024 Category: Hematology Authors: Ann-Rong Yan, Indira Samarawickrema, Mark Naunton, Gregory M. Peterson, Desmond Yip, Phillip Newman, Reza Mortazavi Tags: Review Article Source Type: research
High alpha-2-macroglobulin levels are a risk factor for cardiovascular disease events: A Moli-sani cohort study
α2-macroglobulin (α2M) is a versatile endopeptidase inhibitor that plays a role in cell growth, inflammation and coagulation. α2M is an inhibitor of key coagulation enzyme thrombin. Hypercoagulability due to an excess of thrombin production can cause thrombotic events. Therefore, we investigated the association of α2M levels and cardiovascular events in a subset of the general Italian population. (Source: Thrombosis Research)
Source: Thrombosis Research - January 6, 2024 Category: Hematology Authors: Romy de Laat-Kremers, Simona Costanzo, Qiuting Yan, Augusto Di Castelnuovo, Amalia De Curtis, Chiara Cerletti, Giovanni de Gaetano, Maria Benedetta Donati, Bas de Laat, Licia Iacoviello, Moli-sani Investigators Tags: Full Length Article Source Type: research
Endothelial dysfunction, a predictor of cardiovascular disease in HIV patients on antiretroviral therapy: A systematic review and meta-analysis
AimAlthough antiretroviral therapy (ART) is available, the rate of new HIV infections is alarming. With this trend, it is anticipated that the use of ART will continue to rise, potentially resulting in associated vascular disorders. Therefore, we aimed to examine the impact of ART on endothelial function in people living with HIV (PLHIV), a predictor of cardiovascular diseases. (Source: Thrombosis Research)
Source: Thrombosis Research - January 3, 2024 Category: Hematology Authors: Kay-Lee E. Strauss, Wendy N. Phoswa, Sogolo L. Lebelo, Perpetua Modjadj, Kabelo Mokgalaboni Tags: Review Article Source Type: research
Assessing uptake of the core outcome set in clinical trials for immune thrombocytopenia: A cross-sectional analysis
Clinical trials (CTs) guide clinical practice, but inconsistent outcome reporting presents challenges. To increase comparability, a core outcome set (COS) was created for primary Immune thrombocytopenia (ITP) in 2009 to standardize outcome measurements. We aimed to evaluate uptake of the primary ITP COS in CT registries. (Source: Thrombosis Research)
Source: Thrombosis Research - January 3, 2024 Category: Hematology Authors: Mahad Chaudhry, John K. Stadler, Kyle Fitzgerald, Jay Modi, Garrett Jones, Kimberly Magana, Shaelyn Ward, Trevor Magee, Griffin Hughes, Alicia Ito Ford, Matt Vassar Tags: Full Length Article Source Type: research
Cancer-associated splanchnic vein thrombosis: Clinical implications and management considerations
Splanchnic vein thrombosis (SVT), a thrombosis which involves the portal, mesenteric, and splenic veins, and the Budd-Chiari syndrome, represents an uncommon type of venous thromboembolism (VTE). Like with deep vein thrombosis of the lower extremities and pulmonary embolism, ample evidence suggests a significant association between SVT and cancer, particularly intra-abdominal solid malignancies (e.g. hepatobiliary and pancreatic cancers) and myeloproliferative neoplasms (MPN).Clinical symptoms of SVT in cancer patients can be ambiguous, and frequently attributed to the primary cancer itself. (Source: Thrombosis Research)
Source: Thrombosis Research - January 2, 2024 Category: Hematology Authors: Omri Cohen, Lucia Maria Caiano, Sarina Levy-Mendelovich Source Type: research
