Differential regulation of human thrombospondin-1 upon systemic desmopressin versus endotoxin challenge

Von Willebrand factor (vWF) and thrombospondin-1 (TSP-1) are glycoproteins with procoagulant and prothrombotic properties, playing additional roles in inflammation and cell adhesion [1,2]. They are stored in granules of platelets and endothelial cells (ECs) and are released upon cell activation by agonists like lipopolysaccharide (LPS) or desmopressin [1,2]. In vivo changes in blood concentrations of vWF have previously been studied in human models of desmopressin or low-dose LPS administration to healthy volunteers [3 –5], while little is known about the time course of TSP-1 plasma concentrations in these settings [6].

Source: Thrombosis Research - January 15, 2024 Category: Hematology Authors: Andreas Scheuba, Branislav Zagrapan, Luca Martelanz, Vanessa Eder, Nahla Ibrahim, Sonja Bleichert, Viktoria Kn öbl, Hubert Hayden, Sarah von Kuenheim, Katharina Münch, Nina Buchtele, Christian Schoergenhofer, Katarina D. Kovacevic, Edith Lackner, Christ Tags: Letter to the Editors-in-Chief Source Type: research