Mutations of the dimerization site of glycoprotein (GP) VI result in abolished expression
Glycoprotein (GP) VI is a transmembrane receptor of ~65 kDa only expressed on the megakaryocyte-platelet lineage [1]. GPVI, the central platelet collagen receptor that also binds fibrin and additional ligands, has emerged as promising anti-thrombotic target since it has only a limited role in hemostasis, but significantly contributes to thrombosis and ischemic stroke [2,3]. Recently, the positive results obtained by the humanized anti-GPVI Fab fragment Glenzocimab in a phase 1b/2a trial involving patients affected by acute ischemic stroke [4] underscore that targeting GPVI is a valid strategy to also treat thrombo-infla...
Source: Thrombosis Research - October 30, 2023 Category: Hematology Authors: Stefano Navarro, Timo V ögtle, Nina Groß, Julia Preu, Maximilian Englert, Bernhard Nieswandt, Michael R. Bösl, David Stegner Tags: Letter to the Editors-in-Chief Source Type: research
Gastrointestinal bleeding with direct oral anticoagulants in patients with atrial fibrillation and anaemia
A high risk of gastrointestinal bleeding has been reported with the use of some direct oral anticoagulants (DOACs). This risk may be of particular concern in individuals with associated anaemia. The aim of this study is to investigate potential differences in the risks of gastrointestinal bleeding and stroke among the four available DOACs in patients with atrial fibrillation (AF) and moderate or severe anaemia. (Source: Thrombosis Research)
Source: Thrombosis Research - October 29, 2023 Category: Hematology Authors: Nour Al-Hussainy, Kristian Hay Kragholm, S øren Lundbye-Christensen, Christian Torp-Pedersen, Manan Pareek, Susette Krohn Therkelsen, Gregory Y.H. Lip, Sam Riahi Tags: Full Length Article Source Type: research
Identifying patients with prostate cancer at increased risk for haematuria during anticoagulation for venous thromboembolism
Haematuria is a common complication in prostate cancer patients receiving anticoagulation for venous thromboembolism (VTE). Early identification of at-risk patients might help to reduce its incidence and severity. (Source: Thrombosis Research)
Source: Thrombosis Research - October 28, 2023 Category: Hematology Authors: Diana Paredes, Mar ía del Carmen Díaz-Pedroche, Covadonga Gómez-Cuervo, Asunción Pérez-Jacoiste, Reina Valle, Ángeles Blanco-Molina, Juan Bosco López-Sáez, Jose Meireles, Gabrielle Sarlon-Bartoli, Manuel Monreal, RIETE investigators Tags: Full Length Article Source Type: research
RNA-sequencing to discover genes and signaling pathways associated with venous thromboembolism in glioblastoma patients: A case-control study
Glioblastoma patients are at high risk of developing venous thromboembolism (VTE). Tumor-intrinsic features are considered to play a role, but the underlying pathophysiological mechanisms remain incompletely understood. (Source: Thrombosis Research)
Source: Thrombosis Research - October 27, 2023 Category: Hematology Authors: Maaike Y. Kapteijn, Vincent R. Lanting, Fleur H.J. Kaptein, Noori A.M. Guman, El Houari Laghmani, Thomas B. Kuipers, Hailiang Mei, J.J. Goeman, Frits I. Mulder, Sjoerd G. van Duinen, Martin J.B. Taphoorn, Linda Dirven, Marike L.D. Broekman, Nick van Es, F Source Type: research
Application of the RIETE score to identify low-risk patients with pulmonary embolism: From the COMMAND VTE Registry
The RIETE score could be specifically useful for identification of low-risk pulmonary embolism (PE) patients for home treatment. However, the external validation of the RIETE score has been limited. (Source: Thrombosis Research)
Source: Thrombosis Research - October 24, 2023 Category: Hematology Authors: Yuta Tsujisaka, Yugo Yamashita, Takeshi Morimoto, Toru Takase, Seiichi Hiramori, Kitae Kim, Maki Oi, Masaharu Akao, Yohei Kobayashi, Po-Min Chen, Koichiro Murata, Yoshiaki Tsuyuki, Yuji Nishimoto, Jiro Sakamoto, Kiyonori Togi, Hiroshi Mabuchi, Kensuke Tak Tags: Full Length Article Source Type: research
Co-administered oral anticoagulants with nonsteroidal anti-inflammatory drugs and the risk of bleeding: A systematic review and meta-analysis
The bleeding risk of individuals taking nonsteroidal anti-inflammatory drugs (NSAIDs) concomitantly with oral anticoagulants (OACs) compared to OACs alone remains controversial. This meta-analysis aims to evaluate the bleeding risk of concomitant use of OACs and NSAIDs, and to make comparisons between different OACs types. (Source: Thrombosis Research)
Source: Thrombosis Research - October 22, 2023 Category: Hematology Authors: Yi Zheng, Nan Zhang, Gary Tse, Guangping Li, Gregory Y.H. Lip, Tong Liu Source Type: research
Machine learning model for predicting physical activity related bleeding risk in Chinese boys with haemophilia A
Physical activity is a crucial part of an active lifestyle for haemophiliac children. However, the fear of bleeds has been identified as barriers to participating physical activity for haemophiliac children even with prophylaxis. Lack of evidence and metrics driven by data is key problem. (Source: Thrombosis Research)
Source: Thrombosis Research - October 21, 2023 Category: Hematology Authors: Di Ai, Chang Cui, Yongqiang Tang, Yan Wang, Ningning Zhang, Chenyang Zhang, Yingzi Zhen, Gang Li, Kun Huang, Guoqing Liu, Zhenping Chen, Wensheng Zhang, Runhui Wu Tags: Full Length Article Source Type: research
Performance of age-adjusted and fixed threshold D-dimer to exclude DVT in those with low pre-test probability – Single centre experience
Deep vein thrombosis (DVT) is common with potential for significant morbidity due to consequent pulmonary embolism and post-thrombotic syndrome. As the clinical presentation is non-specific, and the gold standard diagnostic tool of compression venous ultrasonography is a limited resource, diagnostic algorithms have been developed to risk-stratify patients requiring further investigation. In clinical practice, those with a high clinical pre-test probability (PTP) proceed direct to imaging, and those with a low PTP have a D-dimer measured to determine the need for imaging [1,2]. (Source: Thrombosis Research)
Source: Thrombosis Research - October 17, 2023 Category: Hematology Authors: Anna Gazes, Victoria Speed, Julia R. Czuprynska, Bipin Vadher, Roopen Arya, Lara N. Roberts Tags: Letter to the Editors-in-Chief Source Type: research
Role of neutrophil extracellular traps in vascular access thrombosis in hemodialysis patients
A patent vascular access (VA) is a lifeline for hemodialysis (HD) patients. However, vascular access is prone to thrombosis, which, if left untreated, can lead to permanent VA loss and increased mortality. Neutrophil extracellular traps (NETs) are known to be involved in intravascular thrombosis. We evaluated the relationship between NETs and VA thrombosis and their impact on VA prognosis. (Source: Thrombosis Research)
Source: Thrombosis Research - October 14, 2023 Category: Hematology Authors: Ji Hwan Kim, Hyung Seok Lee, Mi Jung Kwon, Young Rim Song, Sung Gyun Kim, Jwa-Kyung Kim Tags: Full Length Article Source Type: research
Development and internal validation of a clinical prediction model for individualized dosing of BAY 81-8973, A full-length recombinant factor VIII, in pediatric patients with haemophilia A
As the most commonly used coagulation factor VIII (FVIII) concentrate in China, the individualized dosing prediction model of Kovaltry (BAY81 –8973) is not fully investigated in pediatric patients. The prophylaxis tailored by population pharmacokinetic (PopPK) model can optimize dosing regimens. (Source: Thrombosis Research)
Source: Thrombosis Research - October 13, 2023 Category: Hematology Authors: Huan He, Kun Huang, Xiaoling Cheng, Xinyi Wu, Runhui Wu, Xiaoling Wang Tags: Full Length Article Source Type: research
The prevalence of relevant drug-drug interactions and associated clinical outcomes in patients with cancer-associated thrombosis on concurrent anticoagulation and anticancer or supportive care therapies
A main concern in the management of patients with cancer-associated thrombosis (CAT) is drug-drug interactions (DDIs) between anticoagulants and anticancer therapies. Their clinical implications remain unclear. (Source: Thrombosis Research)
Source: Thrombosis Research - October 11, 2023 Category: Hematology Authors: Tzu-Fei Wang, Madeleine Hill, Ranjeeta Mallick, Hina Chaudry, Ubabuko Unachukwu, Aur élien Delluc, Marc Carrier Tags: Full Length Article Source Type: research
The Nijmegen ultra-sensitive Bethesda Assay detects very low-titer factor VIII inhibitors in patients with congenital and acquired hemophilia A
An inhibitor can develop in congenital hemophilia A (HA) patients against exogenous infused factor (F)VIII, whereas in acquired HA (AHA) inhibitors initially develop against endogenous FVIII. Inhibitors can be detected with the Nijmegen Bethesda Assay (NBA), which has an international cut-off level of 0.60 Nijmegen Bethesda Units/mL (NBU/mL). Thereby, very low-titer inhibitors may remain undetected. (Source: Thrombosis Research)
Source: Thrombosis Research - October 10, 2023 Category: Hematology Authors: Lars L.F.G. Valke, Marieke J.A. Verhagen, Bart T.P.M. Mulders, Robert Polenewen, Nicole M.A. Blijlevens, Joop H. Jansen, Hassan Mansouritorghabeh, Einas Elsheikh, Birgit M. Reipert, Peter L. Turecek, James S. O'Donnell, Sanna R. Rijpma, Saskia E.M. Schols Tags: Full Length Article Source Type: research
Anticoagulation in chronic thromboembolic pulmonary hypertension: A systematic review and meta-analysis
Life-long anticoagulation is the recommended management for chronic thromboembolic pulmonary hypertension (CTEPH). Evidence regarding the use of direct oral anticoagulants (DOAC) for CTEPH is yet to be established. We performed a systematic review and meta-analysis to clarify the outcomes of CTEPH in patients who used DOAC or vitamin K antagonists (VKA). (Source: Thrombosis Research)
Source: Thrombosis Research - October 9, 2023 Category: Hematology Authors: Yoshiko Ishisaka, Atsuyuki Watanabe, Hisato Takagi, David Steiger, Toshiki Kuno Source Type: research
Cancer-associated splanchnic vein thrombosis: Clinical features upon diagnosis and short-term outcomes
This study aimed to describe the clinical presentation and short-term outcomes of patients with cancer-associated SVT. (Source: Thrombosis Research)
Source: Thrombosis Research - October 8, 2023 Category: Hematology Authors: Adrian Garcia-Villa, Juan Jos é Criado-Álvarez, María Carnevali, Mario Aramberri, Carme Font, Carmen Diaz-Pedroche Tags: Full Length Article Source Type: research
Low-grade endotoxemia and risk of recurrent thrombosis in primary antiphospholipid syndrome. The multicenter ATHERO-APS study
Low-grade endotoxemia is associated with systemic inflammation, enhanced oxidative stress and cardiovascular events in different clinical settings, but its possible role as “second hit” in patients with primary antiphospholipid syndrome (PAPS) has never been investigated. (Source: Thrombosis Research)
Source: Thrombosis Research - October 7, 2023 Category: Hematology Authors: Tommaso Bucci, Paul R.J. Ames, Vittoria Cammisotto, Chiara Cardamone, Antonio Ciampa, Bianca Mangoni, Massimo Triggiani, Roberto Carnevale, Gregory Y.H. Lip, Daniele Pastori, Pasquale Pignatelli, ATHERO-APS study group Tags: Full Length Article Source Type: research
