High alpha-2-macroglobulin levels are a risk factor for cardiovascular disease events: A Moli-sani cohort study

α2-macroglobulin (α2M) is a versatile endopeptidase inhibitor that plays a role in cell growth, inflammation and coagulation. α2M is an inhibitor of key coagulation enzyme thrombin. Hypercoagulability due to an excess of thrombin production can cause thrombotic events. Therefore, we investigated the association of α2M levels and cardiovascular events in a subset of the general Italian population.

Source: Thrombosis Research - January 6, 2024 Category: Hematology Authors: Romy de Laat-Kremers, Simona Costanzo, Qiuting Yan, Augusto Di Castelnuovo, Amalia De Curtis, Chiara Cerletti, Giovanni de Gaetano, Maria Benedetta Donati, Bas de Laat, Licia Iacoviello, Moli-sani Investigators Tags: Full Length Article Source Type: research