The international normalised ratio to monitor coagulation factor production during normothermic machine perfusion of human donor livers

Normothermic machine perfusion (NMP) of donor livers allows for new diagnostic and therapeutic strategies. As the liver produces most of the haemostatic proteins, coagulation assays such as the International Normalised Ratio (INR) performed in perfusate may be useful to assess hepatocellular function of donor livers undergoing NMP. However, high concentrations of heparin and low levels of fibrinogen may affect coagulation assays.
Source: Thrombosis Research - Category: Hematology Authors: Tags: Full Length Article Source Type: research