ROS-driven structural and functional fibrinogen modifications are reverted by interleukin-6 inhibition in giant cell arteritis

Cranial and extra-cranial vascular events are among the major determinants of morbidity and mortality in Giant Cell Arteritis (GCA). Vascular events seem mostly of inflammatory nature, although the precise pathogenetic mechanisms are still unclear. We investigated the role of oxidation-induced structural and functional fibrinogen modifications in GCA. The effects of the anti-IL6R tocilizumab in counteracting these mechanisms were also assessed.

Source: Thrombosis Research - August 15, 2023 Category: Hematology Authors: Alessandra Bettiol, Flavia Rita Argento, Eleonora Fini, Federica Bello, Gerardo Di Scala, Niccol ò Taddei, Giacomo Emmi, Domenico Prisco, Matteo Becatti, Claudia Fiorillo Source Type: research