The International Journal of Biochemistry and Cell Biology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Tumor necrosis factor α-induced protein 8-like-2 controls microglia phenotype via metabolic reprogramming in BV2 microglial cells and responses to neuropathic pain
This study reveals that TNFAIP8L2 plays a critical role in neuropathic pain, providing important insights into glucose metabolic reprogramming and microglial phenotypic transition, which indicates that TNFAIP8L2 may be used as a potential drug target for the prevention of neuropathic pain.PMID:38309648 | DOI:10.1016/j.biocel.2024.106541 (Source: The International Journal of Biochemistry and Cell Biology)
Source: The International Journal of Biochemistry and Cell Biology - February 3, 2024 Category: Biochemistry Authors: Yeqi Li Cui Yin Jinhong Jiang Huan Yang Feifei Zhang Yanhong Xing Wuyang Wang Chen Lu Source Type: research

Exploring Advances in Single Particle CryoEM with Apoferritin: from Blobs to True Atomic Resolution
Int J Biochem Cell Biol. 2024 Jan 31:106536. doi: 10.1016/j.biocel.2024.106536. Online ahead of print.ABSTRACTDeciphering the three-dimensional structures of macromolecules is of paramount importance for gaining insights into their functions and roles in human health and disease. Single particle cryoEM has emerged as a powerful technique that enables direct visualization of macromolecules and their complexes, and through subsequent averaging, achieve near atomic-level resolution. A major breakthrough was recently achieved with the determination of the apoferritin structure at true atomic resolution. In this review, we disc...
Source: The International Journal of Biochemistry and Cell Biology - February 2, 2024 Category: Biochemistry Authors: Gowtham ThambraRajan Premageetha Kutti R Vinothkumar Sucharita Bose Source Type: research

AKT2 deficiency alleviates doxorubicin-induced cardiac injury via alleviating oxidative stress in cardiomyocytes
This study aims to explore the role of AKT serine/threonine kinase 2 (AKT2) in mitigating DOX-induced oxidative stress within the heart through both intracellular and extracellular signaling pathways. Utilizing Akt2 knockout (KO) and Nrf2 KO murine models, alongside neonatal rat cardiomyocytes (NRCMs), we systematically investigate the impact of AKT2 deficiency on DOX-induced cardiac injury. Our findings reveal that DOX administration induces significant oxidative stress, a primary contributor to cardiac injury. Importantly, Akt2 deficiency exhibits a protective effect by alleviating DOX-induced oxidative stress. Mechanist...
Source: The International Journal of Biochemistry and Cell Biology - January 30, 2024 Category: Biochemistry Authors: Jiawen Chen Xiaozhi Xu Yuru Shao Xiaohong Bian Ruiyan Li Yubin Zhang Yibei Xiao Meiling Lu Qizhou Jiang Yuan Zeng Fangrong Yan Junmei Ye Zhe Li Source Type: research

Jun/Fos promotes migration and invasion of hepatocellular carcinoma cells by enhancing BORIS promoter activity
In conclusion, these results suggest that Jun and Fos can promote the development of hepatocellular carcinoma by directly regulating the expression of BORIS. These findings may provide experimental evidence positioning BORIS as a novel target for the clinical intervention of hepatocellular carcinoma.PMID:38281696 | DOI:10.1016/j.biocel.2024.106540 (Source: The International Journal of Biochemistry and Cell Biology)
Source: The International Journal of Biochemistry and Cell Biology - January 28, 2024 Category: Biochemistry Authors: Longjun Xian Yimei Xiong Lu Qin Ling Wei Siqi Zhou Qinda Wang Qiang Fu Mingmei Chen Yang Qin Source Type: research

DNMT1 Y495C mutation interferes with maintenance methylation of imprinting control regions
Int J Biochem Cell Biol. 2024 Jan 26:106535. doi: 10.1016/j.biocel.2024.106535. Online ahead of print.ABSTRACTHereditary Sensory and Autonomic Neuropathy Type 1E (HSAN1E) is a rare autosomal dominant neurological disorder due to missense mutations in DNA methyltransferase 1 (DNMT1). To investigate the nature of the dominant effect, we compared methylomes of transgenic R1wtDnmt1 and R1Dnmt1Y495C mouse embryonic stem cells (mESCs) overexpressing WT and the mutant mouse proteins respectively, with the R1 (wild-type) cells. In case of R1Dnmt1Y495C, 15 out of the 20 imprinting control regions were hypomethylated with transcript...
Source: The International Journal of Biochemistry and Cell Biology - January 28, 2024 Category: Biochemistry Authors: Sumana Choudhury Anuhya Anne Minali Singh John Richard Chaillet Kommu Naga Mohan Source Type: research

Discriminatory power of a circulating multi-noncoding RNA panel in acute coronary syndrome subtypes: Towards precision detection
CONCLUSION: The findings underscore the promising potential of the multi-ncRNA panel as a robust tool for early ACS detection, and precise differentiation among ACS subtypes, and as a potential therapeutic target.PMID:38280541 | DOI:10.1016/j.biocel.2024.106531 (Source: The International Journal of Biochemistry and Cell Biology)
Source: The International Journal of Biochemistry and Cell Biology - January 27, 2024 Category: Biochemistry Authors: Sara H A Agwa Sherif Samir Elzahwy Nourhan Hossam Yahia A Yahia Shaimaa Hamady Nadine Sherif Ahmed Elshazly Reham M Darwish Jomana Osama Hashim Mahmoud Ashraf Adly Aya M Abd Elsamee Rania Shamekh Marian Maher Salib Roushdy Marwa Matboli Source Type: research

The role of high mobility group AT-hook 1 in viral infections: Implications for cancer pathogenesis
Int J Biochem Cell Biol. 2024 Jan 24;169:106532. doi: 10.1016/j.biocel.2024.106532. Online ahead of print.ABSTRACTThe crucial role of high mobility group AT-hook 1 (HMGA1) proteins in nuclear processes such as gene transcription, DNA replication, and chromatin remodeling is undeniable. Elevated levels of HMGA1 have been associated with unfavorable clinical outcomes and adverse differentiation status across various cancer types. HMGA1 regulates a diverse array of biological pathways, including tumor necrosis factor-alpha/nuclear factor-kappa B (TNF-α/NF-κB), epidermal growth factor receptor (EGFR), Hippo, Rat sarcoma/extr...
Source: The International Journal of Biochemistry and Cell Biology - January 26, 2024 Category: Biochemistry Authors: Esma'il Akade Shahram Jalilian Source Type: research

To what extent may aminochrome increase the vulnerability of dopaminergic neurons in the context of Parkinson's disease
Int J Biochem Cell Biol. 2024 Mar;168:106528. doi: 10.1016/j.biocel.2024.106528. Epub 2024 Jan 19.ABSTRACTParkinson's disease (PD) is a neurodegenerative disorder that progresses over time and is characterized by preferential reduction of dopaminergic neurons in the substantia nigra. Although the precise mechanisms leading to cell death in neurodegenerative disorders, such as PD, are not fully understood, it is widely accepted that increased oxidative stress may be a prevalent factor contributing to the deterioration of the nigrostriatal dopaminergic fibers in such conditions. Aminochrome, generated from dopamine (DA) meta...
Source: The International Journal of Biochemistry and Cell Biology - January 21, 2024 Category: Biochemistry Authors: Abdeslam Chagraoui Youssef Anouar Philippe De Deurwaerdere Hugo R Arias Source Type: research

Recent advances in the investigation of fusion RNAs and their role in molecular pathology of cancer
Int J Biochem Cell Biol. 2024 Mar;168:106529. doi: 10.1016/j.biocel.2024.106529. Epub 2024 Jan 19.ABSTRACTGene fusions have had a significant role in the development of various types of cancer, oftentimes involved in oncogenic activities through dysregulation of gene expression or signalling pathways. Some cancer-associated chromosomal translocations can undergo backsplicing, resulting in fusion-circular RNAs, a more stable isoform immune to RNase degradation. This stability makes fusion circular RNAs a promising diagnostic biomarker for cancer. While the detection of linear fusion RNAs and their function in certain cancer...
Source: The International Journal of Biochemistry and Cell Biology - January 21, 2024 Category: Biochemistry Authors: Si-Mei Xu Yuning Cheng Harry Fisher Michael Janitz Source Type: research

Sulfasalazine ameliorates lipopolysaccharide-induced acute lung injury by inhibiting oxidative stress and nuclear factor-kappaB pathways
Int J Biochem Cell Biol. 2024 Jan 19;169:106530. doi: 10.1016/j.biocel.2024.106530. Online ahead of print.ABSTRACTAcute lung injury/acute respiratory distress syndrome (ALI/ARDS) has a high mortality rate and incidence of complications. The pathophysiology of ALI/ARDS is still not fully understood. The lipopolysaccharide (LPS)-induced mouse model of ALI has been widely used to study human ALI/ARDS. Sulfasalazine (SASP) has antibacterial and anti-inflammatory effects and is used for treating inflammatory bowel and rheumatic diseases. However, the effect of SASP on LPS-induced ALI in mice has not yet been reported. Therefore...
Source: The International Journal of Biochemistry and Cell Biology - January 21, 2024 Category: Biochemistry Authors: Hai-Peng Cheng Xing-Wen Bao Yong-Yu Luo Yang-Hang Li Yan Zhou Qing-Zhong Hua Yu-Jia Qiu Xin-Yue Liang Yan-Hong Huang Wei Liu Si-Yuan Tang Dan-Dan Feng Chen Li Zi-Qiang Luo Source Type: research

Variant of uncertain significance Arg866Cys enhances disorderedness of h-BRCA1 (759-1064) region
Int J Biochem Cell Biol. 2024 Mar;168:106527. doi: 10.1016/j.biocel.2024.106527. Epub 2024 Jan 17.ABSTRACTHigh structural flexibility has been reported in the central region of BRCA1, which hinders the structural and functional evaluations of mutations identified in the domain. Additionally, the need to categorize variants of unknown significance (VUS) has increased due to the growth in the number of variants reported in clinical settings. Therefore, unraveling the disease-causing mechanism of VUS identified in different functional domains of BRCA1 is still challenging. The current study uses a multidisciplinary approach t...
Source: The International Journal of Biochemistry and Cell Biology - January 19, 2024 Category: Biochemistry Authors: Neha Mishra Suchita Dubey Anchala Kumari M Quadir Siddiqui Ekaterina Kuligina Ashok K Varma Source Type: research

Blocking the E2F transcription factor 1/high-mobility group box 2 pathway enhances the intervention effects of α-santalol on the malignant behaviors of liver cancer cells
Int J Biochem Cell Biol. 2024 Mar;168:106516. doi: 10.1016/j.biocel.2024.106516. Epub 2024 Jan 12.ABSTRACTIn view of the tumor-inhibiting effect of α-santalol in various cancers and the role of E2F transcription factor 1 (E2F1) as an important target for anticancer research, this study investigates the relation between α-santalol and E2F1, as well as the effect of α-santalol on liver cancer progression and the corresponding mechanism. Concretely, liver cancer cells were treated with different concentrations of α-santalol. The IC50 value of α-santalol was determined using Probit regression analysis. Then, transcription...
Source: The International Journal of Biochemistry and Cell Biology - January 14, 2024 Category: Biochemistry Authors: Hui Wang Min Tang Erli Pei Ying Shen Aili Wang Moubin Lin Source Type: research

The role of α7 nicotinic acetylcholine receptors in post-acute sequelae of covid-19
Int J Biochem Cell Biol. 2024 Mar;168:106519. doi: 10.1016/j.biocel.2024.106519. Epub 2024 Jan 11.ABSTRACTPost-Acute Sequelae of COVID-19 or Long COVID becomes evident some weeks to months following acute COVID-19. Symptoms include cognitive impairment and varying degrees of memory loss with no definitive etiologies or efficacious therapies forthcoming even after four years of the SARS-Cov2 pandemic virus. The aim of this review is to demonstrate the important role of α7 nicotinic acetylcholine receptors in both acute COVID-19 and Long COVID. Evidence presented implicates immune mechanisms stimulated by SARS-Cov-2 S-prote...
Source: The International Journal of Biochemistry and Cell Biology - January 13, 2024 Category: Biochemistry Authors: Maryna Skok Source Type: research

BNIP3 in hypoxia-induced mitophagy: Novel insights and promising target for non-alcoholic fatty liver disease
This study aimed to investigate the expression and the role of BNIP3 in NAFLD under hypoxia, and explore its involvement in regulating NAFLD mitophagy, fatty acid β-oxidation both in vivo and in vitro. BNIP3-mediated mitophagy level was analyzed using real-time quantitative polymerase chain reaction, Western blotting, immunofluorescence and electron microscopy. The role of BNIP3 in fatty acid β-oxidation was evaluated using lipid droplet staining, triglyceride content determination, and cellular energy metabolism. The results showed that compared with the HFD-2200 m, the body weight, inflammatory liver injury, and lipid ...
Source: The International Journal of Biochemistry and Cell Biology - January 12, 2024 Category: Biochemistry Authors: Meiyuan Tian Jing Hou Zhe Liu Zhanquan Li Dengliang Huang Yaogang Zhang Yanyan Ma Source Type: research

Hedgehog signalling in CD4 < sup > + < /sup > T helper cell polarisation
Int J Biochem Cell Biol. 2024 Mar;168:106518. doi: 10.1016/j.biocel.2024.106518. Epub 2024 Jan 11.ABSTRACTCD4+ T cells are critical in orchestrating immune responses against various pathogens and cancer but can also be drivers of autoimmune disease, allergy and pro-tumour responses. Naïve CD4+ T cells polarise into specialised T helper cell subsets with unique effector functions. While the guiding transcription factors and effector molecules of the T helper cell lineages are well understood, the signalling pathways orchestrating the intricate T helper cell polarisation programmes remain poorly understood. Here we review a...
Source: The International Journal of Biochemistry and Cell Biology - January 12, 2024 Category: Biochemistry Authors: Joachim Hanna Maike de la Roche Source Type: research