Role of innate lymphoid cells in cancer metastasis
Int J Biochem Cell Biol. 2023 Sep 2:106465. doi: 10.1016/j.biocel.2023.106465. Online ahead of print.ABSTRACTMetastatic spread of cancer accounts for most cancer-related deaths. Cancer seeding in secondary organs requires reprogramming of the local stromal and immune landscape, which ultimately supports tumour growth. Yet, the cellular and molecular mechanisms that promote this tumour-permissive environment remain largely unknown. Innate lymphoid cells (ILCs) have recently been shown to modulate the immune response to cancer in multiple ways. Given their tissue-resident nature, ILCs are well placed to respond to local cues...
Source: The International Journal of Biochemistry and Cell Biology - September 4, 2023 Category: Biochemistry Authors: Julia Moreno-Vicente Timotheus Yf Halim Source Type: research

Role of innate lymphoid cells in cancer metastasis
Int J Biochem Cell Biol. 2023 Sep 2:106465. doi: 10.1016/j.biocel.2023.106465. Online ahead of print.ABSTRACTMetastatic spread of cancer accounts for most cancer-related deaths. Cancer seeding in secondary organs requires reprogramming of the local stromal and immune landscape, which ultimately supports tumour growth. Yet, the cellular and molecular mechanisms that promote this tumour-permissive environment remain largely unknown. Innate lymphoid cells (ILCs) have recently been shown to modulate the immune response to cancer in multiple ways. Given their tissue-resident nature, ILCs are well placed to respond to local cues...
Source: The International Journal of Biochemistry and Cell Biology - September 4, 2023 Category: Biochemistry Authors: Julia Moreno-Vicente Timotheus Yf Halim Source Type: research

Role of innate lymphoid cells in cancer metastasis
Int J Biochem Cell Biol. 2023 Sep 2:106465. doi: 10.1016/j.biocel.2023.106465. Online ahead of print.ABSTRACTMetastatic spread of cancer accounts for most cancer-related deaths. Cancer seeding in secondary organs requires reprogramming of the local stromal and immune landscape, which ultimately supports tumour growth. Yet, the cellular and molecular mechanisms that promote this tumour-permissive environment remain largely unknown. Innate lymphoid cells (ILCs) have recently been shown to modulate the immune response to cancer in multiple ways. Given their tissue-resident nature, ILCs are well placed to respond to local cues...
Source: The International Journal of Biochemistry and Cell Biology - September 4, 2023 Category: Biochemistry Authors: Julia Moreno-Vicente Timotheus Yf Halim Source Type: research

CircABPD1 Alleviates Oxidative Lung Injury of Bronchopulmonary Dysplasia Through Regulating miR-330-3p /HIF1 α Axis
Int J Biochem Cell Biol. 2023 Sep 1:106464. doi: 10.1016/j.biocel.2023.106464. Online ahead of print.ABSTRACTIn the NICU, bronchopulmonary dysplasia (BPD) is a concerning common respiratory complication in preterm and low birth-weight infants. Clinical studies have confirmed that human milk has an important nutritional role for children with BPD, therefore, dentification of beneficial components in human milk that prevent BPD is urgently needed. Our previous work showed that human milk exosomes (HM-Exos) could inhibit apoptosis of alveolar type II epithelial cells (AT II), and the circular RNA (circRNA)-circABPD1 were high...
Source: The International Journal of Biochemistry and Cell Biology - September 3, 2023 Category: Biochemistry Authors: Huimin Li Ke Ma Heng Dou Linjie Liu Yun Qian Shushu Li Jingjing Chen Shuping Han Xiaoqi Gu Jing Yin Source Type: research

CircABPD1 Alleviates Oxidative Lung Injury of Bronchopulmonary Dysplasia Through Regulating miR-330-3p /HIF1 α Axis
Int J Biochem Cell Biol. 2023 Sep 1:106464. doi: 10.1016/j.biocel.2023.106464. Online ahead of print.ABSTRACTIn the NICU, bronchopulmonary dysplasia (BPD) is a concerning common respiratory complication in preterm and low birth-weight infants. Clinical studies have confirmed that human milk has an important nutritional role for children with BPD, therefore, dentification of beneficial components in human milk that prevent BPD is urgently needed. Our previous work showed that human milk exosomes (HM-Exos) could inhibit apoptosis of alveolar type II epithelial cells (AT II), and the circular RNA (circRNA)-circABPD1 were high...
Source: The International Journal of Biochemistry and Cell Biology - September 3, 2023 Category: Biochemistry Authors: Huimin Li Ke Ma Heng Dou Linjie Liu Yun Qian Shushu Li Jingjing Chen Shuping Han Xiaoqi Gu Jing Yin Source Type: research

Using single molecule imaging to explore intracellular heterogeneity
Int J Biochem Cell Biol. 2023 Aug 15;163:106455. doi: 10.1016/j.biocel.2023.106455. Online ahead of print.ABSTRACTDespite more than 100 years of study, it is unclear if the movement of proteins inside the cell is best described as a mosh pit or an exquisitely choreographed dance. Recent studies suggest the latter. Local interactions induce molecular condensates such as liquid-liquid phase separations (LLPSs) or non-liquid, functionally significant molecular aggregates, including synaptic densities, nucleoli, and Amyloid fibrils. Molecular condensates trigger intracellular signaling and drive processes ranging from gene exp...
Source: The International Journal of Biochemistry and Cell Biology - August 16, 2023 Category: Biochemistry Authors: James A Galbraith Catherine G Galbraith Source Type: research

Using single molecule imaging to explore intracellular heterogeneity
Int J Biochem Cell Biol. 2023 Aug 15;163:106455. doi: 10.1016/j.biocel.2023.106455. Online ahead of print.ABSTRACTDespite more than 100 years of study, it is unclear if the movement of proteins inside the cell is best described as a mosh pit or an exquisitely choreographed dance. Recent studies suggest the latter. Local interactions induce molecular condensates such as liquid-liquid phase separations (LLPSs) or non-liquid, functionally significant molecular aggregates, including synaptic densities, nucleoli, and Amyloid fibrils. Molecular condensates trigger intracellular signaling and drive processes ranging from gene exp...
Source: The International Journal of Biochemistry and Cell Biology - August 16, 2023 Category: Biochemistry Authors: James A Galbraith Catherine G Galbraith Source Type: research

Using single molecule imaging to explore intracellular heterogeneity
Int J Biochem Cell Biol. 2023 Aug 15;163:106455. doi: 10.1016/j.biocel.2023.106455. Online ahead of print.ABSTRACTDespite more than 100 years of study, it is unclear if the movement of proteins inside the cell is best described as a mosh pit or an exquisitely choreographed dance. Recent studies suggest the latter. Local interactions induce molecular condensates such as liquid-liquid phase separations (LLPSs) or non-liquid, functionally significant molecular aggregates, including synaptic densities, nucleoli, and Amyloid fibrils. Molecular condensates trigger intracellular signaling and drive processes ranging from gene exp...
Source: The International Journal of Biochemistry and Cell Biology - August 16, 2023 Category: Biochemistry Authors: James A Galbraith Catherine G Galbraith Source Type: research

Using single molecule imaging to explore intracellular heterogeneity
Int J Biochem Cell Biol. 2023 Aug 15;163:106455. doi: 10.1016/j.biocel.2023.106455. Online ahead of print.ABSTRACTDespite more than 100 years of study, it is unclear if the movement of proteins inside the cell is best described as a mosh pit or an exquisitely choreographed dance. Recent studies suggest the latter. Local interactions induce molecular condensates such as liquid-liquid phase separations (LLPSs) or non-liquid, functionally significant molecular aggregates, including synaptic densities, nucleoli, and Amyloid fibrils. Molecular condensates trigger intracellular signaling and drive processes ranging from gene exp...
Source: The International Journal of Biochemistry and Cell Biology - August 16, 2023 Category: Biochemistry Authors: James A Galbraith Catherine G Galbraith Source Type: research

Using single molecule imaging to explore intracellular heterogeneity
Int J Biochem Cell Biol. 2023 Aug 15;163:106455. doi: 10.1016/j.biocel.2023.106455. Online ahead of print.ABSTRACTDespite more than 100 years of study, it is unclear if the movement of proteins inside the cell is best described as a mosh pit or an exquisitely choreographed dance. Recent studies suggest the latter. Local interactions induce molecular condensates such as liquid-liquid phase separations (LLPSs) or non-liquid, functionally significant molecular aggregates, including synaptic densities, nucleoli, and Amyloid fibrils. Molecular condensates trigger intracellular signaling and drive processes ranging from gene exp...
Source: The International Journal of Biochemistry and Cell Biology - August 16, 2023 Category: Biochemistry Authors: James A Galbraith Catherine G Galbraith Source Type: research

Using single molecule imaging to explore intracellular heterogeneity
Int J Biochem Cell Biol. 2023 Aug 15;163:106455. doi: 10.1016/j.biocel.2023.106455. Online ahead of print.ABSTRACTDespite more than 100 years of study, it is unclear if the movement of proteins inside the cell is best described as a mosh pit or an exquisitely choreographed dance. Recent studies suggest the latter. Local interactions induce molecular condensates such as liquid-liquid phase separations (LLPSs) or non-liquid, functionally significant molecular aggregates, including synaptic densities, nucleoli, and Amyloid fibrils. Molecular condensates trigger intracellular signaling and drive processes ranging from gene exp...
Source: The International Journal of Biochemistry and Cell Biology - August 16, 2023 Category: Biochemistry Authors: James A Galbraith Catherine G Galbraith Source Type: research

Using single molecule imaging to explore intracellular heterogeneity
Int J Biochem Cell Biol. 2023 Aug 15;163:106455. doi: 10.1016/j.biocel.2023.106455. Online ahead of print.ABSTRACTDespite more than 100 years of study, it is unclear if the movement of proteins inside the cell is best described as a mosh pit or an exquisitely choreographed dance. Recent studies suggest the latter. Local interactions induce molecular condensates such as liquid-liquid phase separations (LLPSs) or non-liquid, functionally significant molecular aggregates, including synaptic densities, nucleoli, and Amyloid fibrils. Molecular condensates trigger intracellular signaling and drive processes ranging from gene exp...
Source: The International Journal of Biochemistry and Cell Biology - August 16, 2023 Category: Biochemistry Authors: James A Galbraith Catherine G Galbraith Source Type: research

Using single molecule imaging to explore intracellular heterogeneity
Int J Biochem Cell Biol. 2023 Aug 15;163:106455. doi: 10.1016/j.biocel.2023.106455. Online ahead of print.ABSTRACTDespite more than 100 years of study, it is unclear if the movement of proteins inside the cell is best described as a mosh pit or an exquisitely choreographed dance. Recent studies suggest the latter. Local interactions induce molecular condensates such as liquid-liquid phase separations (LLPSs) or non-liquid, functionally significant molecular aggregates, including synaptic densities, nucleoli, and Amyloid fibrils. Molecular condensates trigger intracellular signaling and drive processes ranging from gene exp...
Source: The International Journal of Biochemistry and Cell Biology - August 16, 2023 Category: Biochemistry Authors: James A Galbraith Catherine G Galbraith Source Type: research

Using Single Molecule Imaging to Explore Intracellular Heterogeneity
Int J Biochem Cell Biol. 2023 Aug 14:106455. doi: 10.1016/j.biocel.2023.106455. Online ahead of print.ABSTRACTDespite more than 100 years of study, it is unclear if the movement of proteins inside the cell is best described as a mosh pit or an exquisitely choreographed dance. Recent studies suggest the latter. Local interactions induce molecular condensates such as liquid-liquid phase separations (LLPSs) or non-liquid, functionally significant molecular aggregates, including synaptic densities, nucleoli, and Amyloid fibrils. Molecular condensates trigger intracellular signaling and drive processes ranging from gene express...
Source: The International Journal of Biochemistry and Cell Biology - August 16, 2023 Category: Biochemistry Authors: James A Galbraith Catherine G Galbraith Source Type: research

Using Single Molecule Imaging to Explore Intracellular Heterogeneity
Int J Biochem Cell Biol. 2023 Aug 14:106455. doi: 10.1016/j.biocel.2023.106455. Online ahead of print.ABSTRACTDespite more than 100 years of study, it is unclear if the movement of proteins inside the cell is best described as a mosh pit or an exquisitely choreographed dance. Recent studies suggest the latter. Local interactions induce molecular condensates such as liquid-liquid phase separations (LLPSs) or non-liquid, functionally significant molecular aggregates, including synaptic densities, nucleoli, and Amyloid fibrils. Molecular condensates trigger intracellular signaling and drive processes ranging from gene express...
Source: The International Journal of Biochemistry and Cell Biology - August 16, 2023 Category: Biochemistry Authors: James A Galbraith Catherine G Galbraith Source Type: research