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Iron overload increases the sensitivity of endometriosis stromal cells to ferroptosis via a PRC2-independent function of EZH2
In this study, we examined the impact on ectopic endometrial stromal cells (EESCs) of iron overload and an inducer of ferroptosis. We found that the iron concentration in the ovarian endometriosis was much higher than control samples. Treatment of cultured EESCs with ferric ammonium citrate (FAC) increase the sensitivity to undergo ferroptosis. By analyzing the RNA-seq results, it was discovered that zeste 2 polycomb repressive complex 2 subunit (EZH2) was significantly downregulated in ferroptosis induced EESCs. Moreover, overexpression of EZH2 effectively prevented the induction of ferroptosis. In addition, the activity ...
Source: The International Journal of Biochemistry and Cell Biology - February 28, 2024 Category: Biochemistry Authors: Yong Luo Liping Li Qiwen Hu Ziyu Zhang Faying Liu Yongbao Peng Yang Zou Lina Chen Source Type: research

PLA inhibits TNF- α-induced PANoptosis of prostate cancer cells through metabolic reprogramming
In conclusion, PLA inhibits TNF-α induced panapoptosis of prostate cancer cells through metabolic reprogramming, providing a new idea for targeted treatment of prostate cancer.PMID:38408537 | DOI:10.1016/j.biocel.2024.106554 (Source: The International Journal of Biochemistry and Cell Biology)
Source: The International Journal of Biochemistry and Cell Biology - February 26, 2024 Category: Biochemistry Authors: Yinghui Hao Fangmei Xie Jieyi He Chenqiong Gu Ying Zhao Wenfeng Luo Xiaoyu Song Jian Shen Li Yu Zeping Han Jinhua He Source Type: research

Identification and validation of LINC01322 as a potential prognostic biomarker and oncogene promoting tumor progression in lung adenocarcinoma
Int J Biochem Cell Biol. 2024 Feb 23:106552. doi: 10.1016/j.biocel.2024.106552. Online ahead of print.ABSTRACTOur study identified a novel long noncoding RNA, LINC01322, that acts as an oncogene in lung adenocarcinoma progression. Cytoplasmic and nuclear RNA purification assays indicated that LINC01322 was localized in the cytoplasm and nucleus. Gene set enrichment analysis revealed the involvement of LINC01322 in the regulation of cell proliferation, migration, and the Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway. LINC01322 may promote lung adenocarcinoma proliferation and mig...
Source: The International Journal of Biochemistry and Cell Biology - February 25, 2024 Category: Biochemistry Authors: Lizhong Zeng Ke Mi Lei Peng Haimei Wen Ting Jiao Xin Lyu Tong Jiao Yang Chen Jingyan Yuan Long Zhang Shuanying Yang Source Type: research

The functional significance of circRNA/miRNA/mRNA interactions as a regulatory network in lung cancer biology
Int J Biochem Cell Biol. 2024 Feb 13;169:106548. doi: 10.1016/j.biocel.2024.106548. Online ahead of print.ABSTRACTLung cancer, the leading cause of cancer-related deaths, presents significant challenges to patients due to its poor prognosis. Recent research has increasingly implicated circular RNAs in the development and progression of lung cancer. These circular RNAs have been found to impact various aspects of tumor behavior, including proliferation, metastasis, cell cycle regulation, apoptosis, cancer stem cells, therapy response, and the tumor microenvironment. One of the key mechanisms by which circular RNAs exert the...
Source: The International Journal of Biochemistry and Cell Biology - February 15, 2024 Category: Biochemistry Authors: Shengnan Jia Ling Yu Lihui Wang Liping Peng Source Type: research

S100A4 modulates cell proliferation, apoptosis and fibrosis in the hyperplastic prostate
In conclusion, our novel data demonstrate that S100A4 could play a crucial role in BPH development and may be explored as a new therapeutic target of BPH.PMID:38360265 | DOI:10.1016/j.biocel.2024.106551 (Source: The International Journal of Biochemistry and Cell Biology)
Source: The International Journal of Biochemistry and Cell Biology - February 15, 2024 Category: Biochemistry Authors: Liang Yang Jiang Liu Jing Yin Yan Li Jianmin Liu Daoquan Liu Zhen Wang Michael E DiSanto Weibing Zhang Xinhua Zhang Source Type: research