The International Journal of Biochemistry and Cell Biology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

A global phosphosite-correlated network map of Thousand And One Kinase 1 (TAOK1)
Int J Biochem Cell Biol. 2024 Mar 11:106558. doi: 10.1016/j.biocel.2024.106558. Online ahead of print.ABSTRACTThousand and one amino acid kinase 1 (TAOK1) is a sterile 20 family Serine/Threonine kinase linked to microtubule dynamics, checkpoint signaling, DNA damage response, and neurological functions. Molecular-level alterations of TAOK1 have been associated with neurodevelopment disorders and cancers. Despite their known involvement in physiological and pathophysiological processes, and as a core member of the hippo signaling pathway, the phosphoregulatory network of TAOK1 has not been visualized. Aimed to explore this ...
Source: The International Journal of Biochemistry and Cell Biology - March 13, 2024 Category: Biochemistry Authors: Pahal Priyanka Athira Perunelly Gopalakrishnan Mahammad Nisar Prathik Basthikoppa Shivamurthy Mejo George Levin John Diya Sanjeev Tanuja Yandigeri Sonet D Thomas Ahmad Rafi Shobha Dagamajalu Anoop Kumar G Velikkakath Chandran S Abhinand Saptami Kanekar Th Source Type: research

Naringenin nanoparticles targeting cyclin B1 suppress the progression of rheumatoid arthritis-associated lung cancer by inhibiting fibroblast-to-myofibroblast transition
This study aimed to identify potential molecular targets associated with the progression of rheumatoid arthritis-associated lung cancer and examine the efficacy of naringenin nanoparticles targeting cyclin B1. Mendelian randomizatio analysis revealed that rheumatoid arthritis has a positive correlation with the risk of lung cancer. Cyclin B1 was significantly upregulated in patients with rheumatoid arthritis-associated lung cancer and was significantly overexpressed in synovial tissue fibroblasts. Furthermore, the overexpression of cyclin B1 in rheumatoid arthritis fibroblast-like synoviocytes, which promotes their prolife...
Source: The International Journal of Biochemistry and Cell Biology - March 9, 2024 Category: Biochemistry Authors: Xilong Wang Xiaoyu Zhang Zhipu Liu Na Zhao Xiaohan Li Peng Su Guixi Zheng Xin Zhang Hongxing Wang Yi Zhang Source Type: research

An update on the cell-free DNA-derived methylome as a non-invasive biomarker for coronary artery disease
Int J Biochem Cell Biol. 2024 Feb 28:106555. doi: 10.1016/j.biocel.2024.106555. Online ahead of print.ABSTRACTCardiovascular diseases are the foremost contributor to global mortality, presenting a complex etiology and an expanding array of risk factors. Coronary artery disease characterized by atherosclerotic plaque build-up in the coronary arteries, imposes significant mortality and financial burdens, especially in low- and middle-income nations. The pathogenesis of coronary artery disease involves a multifaceted interplay of genetic, environmental, and epigenetic factors. Epigenetic regulation contributes to the dynamic ...
Source: The International Journal of Biochemistry and Cell Biology - March 1, 2024 Category: Biochemistry Authors: Manoswini Dash Bhawna Mahajan Ghulam Mehdi Dar Parameswar Sahu Sundeep Singh Saluja Source Type: research

The Application of Brain Organoid for Drug Discovery in Mitochondrial Diseases
Int J Biochem Cell Biol. 2024 Feb 27:106556. doi: 10.1016/j.biocel.2024.106556. Online ahead of print.ABSTRACTMitochondrial diseases are difficult to treat due to the complexity and multifaceted nature of mitochondrial dysfunction. Brain organoids are three-dimensional (3D) structures derived from human pluripotent stem cells designed to mimic brain-like development and function. Brain organoids have received a lot of attention in recent years as powerful tools for modeling human diseases, brain development, and drug screening. Screening compounds for mitochondrial diseases using brain organoids could provide a more physio...
Source: The International Journal of Biochemistry and Cell Biology - February 29, 2024 Category: Biochemistry Authors: Kristina Xiao Liang Source Type: research