The International Journal of Biochemistry and Cell Biology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Immunosenescence and macrophages: from basics to therapeutics
Int J Biochem Cell Biol. 2023 Oct 20:106479. doi: 10.1016/j.biocel.2023.106479. Online ahead of print.ABSTRACTAgeing decreases the function of the immune system and increases susceptibility to some chronic, infectious, and autoimmune diseases. Senescence cells, which produce senescence-associated secretory phenotypes (SASPs), can activate the innate and adaptive immune responses. Macrophages are among the most abundant innate immune cell types in senescent microenvironments. Senescence-associated macrophages, recruited by SASPs, play a vital role in establishing the essential microenvironments for maintaining tissue homeos...
Source: The International Journal of Biochemistry and Cell Biology - October 22, 2023 Category: Biochemistry Authors: Hongkang Zhu Fanglin Shen Tingting Liao He Qian Yu Liu Source Type: research

Differential Regulation of Fibronectin Expression and Fibrillogenesis by Autocrine TGF- β1 Signaling in Malignant and Benign Mammary Epithelial Cells
Int J Biochem Cell Biol. 2023 Oct 20:106478. doi: 10.1016/j.biocel.2023.106478. Online ahead of print.ABSTRACTRemodeling of the extracellular matrix (ECM) is a key hallmark of cancer progression. A critical component of ECM remodeling is the assembly of the ECM protein fibronectin (FN) into insoluble fibrils, which provide a scaffold for invading vascular endothelial cells and escaping cancer cells, as well as a framework for collagen deposition and oncogenic cytokine tethering. FN fibril assembly is induced by Transforming Growth Factor-β1 (TGF-β1), which was originally identified for its role in malignant transformatio...
Source: The International Journal of Biochemistry and Cell Biology - October 22, 2023 Category: Biochemistry Authors: Michael M Sofroniou Christopher A Lemmon Source Type: research

DNA mismatch repair deficient cancer - Emerging biomarkers of resistance to immune checkpoint inhibition
Int J Biochem Cell Biol. 2023 Oct 18;164:106477. doi: 10.1016/j.biocel.2023.106477. Online ahead of print.ABSTRACTThe DNA mismatch repair pathway is involved in the identification, excision, and repair of base-base mismatches and indel loops in the genome. Mismatch repair deficiency occurs in approximately 20% of all cancers and results in a type of DNA damage called microsatellite instability. In 2017, the immune checkpoint inhibitor, Pembrolizumab, an anti-PD-1 therapy, was approved for use in all unresectable or metastatic tumours that were mismatch repair deficient or had high microsatellite instability regardless of t...
Source: The International Journal of Biochemistry and Cell Biology - October 20, 2023 Category: Biochemistry Authors: Kirsten Brooksbank Sarah A Martin Source Type: research

MMP13 promotes the osteogenic potential of BMP9 by enhancing Wnt/ β-catenin signaling via HIF-1α upregulation in mouse embryonic fibroblasts
Int J Biochem Cell Biol. 2023 Oct 5;164:106476. doi: 10.1016/j.biocel.2023.106476. Online ahead of print.ABSTRACTBone morphogenetic protein 9 (BMP9) has been validated as one of the most potent osteoinduction factors, but its underlying mechanism remains unclear. As a member of the matrix metalloproteinase (MMP) family, MMP13 may be involved in regulating the lineage-specific differentiation of mouse embryonic fibroblasts (MEFs). The goal of this study was to determine whether MMP13 regulates the osteoinduction potential of BMP9 in MEFs, which are multipotent progenitor cells widely used for stem cell biology research. In ...
Source: The International Journal of Biochemistry and Cell Biology - October 6, 2023 Category: Biochemistry Authors: Yue Jiang Lu Liu Yi-Xuan Deng Jie Zhang Ai-Hua Ye Fang-Lin Ye Bai-Cheng He Source Type: research

MMP13 promotes the osteogenic potential of BMP9 by enhancing Wnt/ β-catenin signaling via HIF-1α upregulation in mouse embryonic fibroblasts
Int J Biochem Cell Biol. 2023 Oct 4:106476. doi: 10.1016/j.biocel.2023.106476. Online ahead of print.ABSTRACTBone morphogenetic protein 9 (BMP9) has been validated as one of the most potent osteoinduction factors, but its underlying mechanism remains unclear. As a member of the matrix metalloproteinase (MMP) family, MMP13 may be involved in regulating the lineage-specific differentiation of mouse embryonic fibroblasts (MEFs). The goal of this study was to determine whether MMP13 regulates the osteoinduction potential of BMP9 in MEFs, which are multipotent progenitor cells widely used for stem cell biology research. In vitr...
Source: The International Journal of Biochemistry and Cell Biology - October 6, 2023 Category: Biochemistry Authors: Yue Jiang Lu Liu Yi-Xuan Deng Jie Zhang Ai-Hua Ye Fang-Lin Ye Bai-Cheng He Source Type: research