Naringenin nanoparticles targeting cyclin B1 suppress the progression of rheumatoid arthritis-associated lung cancer by inhibiting fibroblast-to-myofibroblast transition
This study aimed to identify potential molecular targets associated with the progression of rheumatoid arthritis-associated lung cancer and examine the efficacy of naringenin nanoparticles targeting cyclin B1. Mendelian randomizatio analysis revealed that rheumatoid arthritis has a positive correlation with the risk of lung cancer. Cyclin B1 was significantly upregulated in patients with rheumatoid arthritis-associated lung cancer and was significantly overexpressed in synovial tissue fibroblasts. Furthermore, the overexpression of cyclin B1 in rheumatoid arthritis fibroblast-like synoviocytes, which promotes their prolife...
Source: The International Journal of Biochemistry and Cell Biology - March 9, 2024 Category: Biochemistry Authors: Xilong Wang Xiaoyu Zhang Zhipu Liu Na Zhao Xiaohan Li Peng Su Guixi Zheng Xin Zhang Hongxing Wang Yi Zhang Source Type: research

Naringenin nanoparticles targeting cyclin B1 suppress the progression of rheumatoid arthritis-associated lung cancer by inhibiting fibroblast-to-myofibroblast transition
This study aimed to identify potential molecular targets associated with the progression of rheumatoid arthritis-associated lung cancer and examine the efficacy of naringenin nanoparticles targeting cyclin B1. Mendelian randomizatio analysis revealed that rheumatoid arthritis has a positive correlation with the risk of lung cancer. Cyclin B1 was significantly upregulated in patients with rheumatoid arthritis-associated lung cancer and was significantly overexpressed in synovial tissue fibroblasts. Furthermore, the overexpression of cyclin B1 in rheumatoid arthritis fibroblast-like synoviocytes, which promotes their prolife...
Source: The International Journal of Biochemistry and Cell Biology - March 9, 2024 Category: Biochemistry Authors: Xilong Wang Xiaoyu Zhang Zhipu Liu Na Zhao Xiaohan Li Peng Su Guixi Zheng Xin Zhang Hongxing Wang Yi Zhang Source Type: research

Naringenin nanoparticles targeting cyclin B1 suppress the progression of rheumatoid arthritis-associated lung cancer by inhibiting fibroblast-to-myofibroblast transition
This study aimed to identify potential molecular targets associated with the progression of rheumatoid arthritis-associated lung cancer and examine the efficacy of naringenin nanoparticles targeting cyclin B1. Mendelian randomizatio analysis revealed that rheumatoid arthritis has a positive correlation with the risk of lung cancer. Cyclin B1 was significantly upregulated in patients with rheumatoid arthritis-associated lung cancer and was significantly overexpressed in synovial tissue fibroblasts. Furthermore, the overexpression of cyclin B1 in rheumatoid arthritis fibroblast-like synoviocytes, which promotes their prolife...
Source: The International Journal of Biochemistry and Cell Biology - March 9, 2024 Category: Biochemistry Authors: Xilong Wang Xiaoyu Zhang Zhipu Liu Na Zhao Xiaohan Li Peng Su Guixi Zheng Xin Zhang Hongxing Wang Yi Zhang Source Type: research

Naringenin nanoparticles targeting cyclin B1 suppress the progression of rheumatoid arthritis-associated lung cancer by inhibiting fibroblast-to-myofibroblast transition
This study aimed to identify potential molecular targets associated with the progression of rheumatoid arthritis-associated lung cancer and examine the efficacy of naringenin nanoparticles targeting cyclin B1. Mendelian randomizatio analysis revealed that rheumatoid arthritis has a positive correlation with the risk of lung cancer. Cyclin B1 was significantly upregulated in patients with rheumatoid arthritis-associated lung cancer and was significantly overexpressed in synovial tissue fibroblasts. Furthermore, the overexpression of cyclin B1 in rheumatoid arthritis fibroblast-like synoviocytes, which promotes their prolife...
Source: The International Journal of Biochemistry and Cell Biology - March 9, 2024 Category: Biochemistry Authors: Xilong Wang Xiaoyu Zhang Zhipu Liu Na Zhao Xiaohan Li Peng Su Guixi Zheng Xin Zhang Hongxing Wang Yi Zhang Source Type: research

An update on the cell-free DNA-derived methylome as a non-invasive biomarker for coronary artery disease
Int J Biochem Cell Biol. 2024 Feb 28:106555. doi: 10.1016/j.biocel.2024.106555. Online ahead of print.ABSTRACTCardiovascular diseases are the foremost contributor to global mortality, presenting a complex etiology and an expanding array of risk factors. Coronary artery disease characterized by atherosclerotic plaque build-up in the coronary arteries, imposes significant mortality and financial burdens, especially in low- and middle-income nations. The pathogenesis of coronary artery disease involves a multifaceted interplay of genetic, environmental, and epigenetic factors. Epigenetic regulation contributes to the dynamic ...
Source: The International Journal of Biochemistry and Cell Biology - March 1, 2024 Category: Biochemistry Authors: Manoswini Dash Bhawna Mahajan Ghulam Mehdi Dar Parameswar Sahu Sundeep Singh Saluja Source Type: research

An update on the cell-free DNA-derived methylome as a non-invasive biomarker for coronary artery disease
Int J Biochem Cell Biol. 2024 Feb 28:106555. doi: 10.1016/j.biocel.2024.106555. Online ahead of print.ABSTRACTCardiovascular diseases are the foremost contributor to global mortality, presenting a complex etiology and an expanding array of risk factors. Coronary artery disease characterized by atherosclerotic plaque build-up in the coronary arteries, imposes significant mortality and financial burdens, especially in low- and middle-income nations. The pathogenesis of coronary artery disease involves a multifaceted interplay of genetic, environmental, and epigenetic factors. Epigenetic regulation contributes to the dynamic ...
Source: The International Journal of Biochemistry and Cell Biology - March 1, 2024 Category: Biochemistry Authors: Manoswini Dash Bhawna Mahajan Ghulam Mehdi Dar Parameswar Sahu Sundeep Singh Saluja Source Type: research

An update on the cell-free DNA-derived methylome as a non-invasive biomarker for coronary artery disease
Int J Biochem Cell Biol. 2024 Feb 28:106555. doi: 10.1016/j.biocel.2024.106555. Online ahead of print.ABSTRACTCardiovascular diseases are the foremost contributor to global mortality, presenting a complex etiology and an expanding array of risk factors. Coronary artery disease characterized by atherosclerotic plaque build-up in the coronary arteries, imposes significant mortality and financial burdens, especially in low- and middle-income nations. The pathogenesis of coronary artery disease involves a multifaceted interplay of genetic, environmental, and epigenetic factors. Epigenetic regulation contributes to the dynamic ...
Source: The International Journal of Biochemistry and Cell Biology - March 1, 2024 Category: Biochemistry Authors: Manoswini Dash Bhawna Mahajan Ghulam Mehdi Dar Parameswar Sahu Sundeep Singh Saluja Source Type: research

An update on the cell-free DNA-derived methylome as a non-invasive biomarker for coronary artery disease
Int J Biochem Cell Biol. 2024 Feb 28:106555. doi: 10.1016/j.biocel.2024.106555. Online ahead of print.ABSTRACTCardiovascular diseases are the foremost contributor to global mortality, presenting a complex etiology and an expanding array of risk factors. Coronary artery disease characterized by atherosclerotic plaque build-up in the coronary arteries, imposes significant mortality and financial burdens, especially in low- and middle-income nations. The pathogenesis of coronary artery disease involves a multifaceted interplay of genetic, environmental, and epigenetic factors. Epigenetic regulation contributes to the dynamic ...
Source: The International Journal of Biochemistry and Cell Biology - March 1, 2024 Category: Biochemistry Authors: Manoswini Dash Bhawna Mahajan Ghulam Mehdi Dar Parameswar Sahu Sundeep Singh Saluja Source Type: research

An update on the cell-free DNA-derived methylome as a non-invasive biomarker for coronary artery disease
Int J Biochem Cell Biol. 2024 Feb 28:106555. doi: 10.1016/j.biocel.2024.106555. Online ahead of print.ABSTRACTCardiovascular diseases are the foremost contributor to global mortality, presenting a complex etiology and an expanding array of risk factors. Coronary artery disease characterized by atherosclerotic plaque build-up in the coronary arteries, imposes significant mortality and financial burdens, especially in low- and middle-income nations. The pathogenesis of coronary artery disease involves a multifaceted interplay of genetic, environmental, and epigenetic factors. Epigenetic regulation contributes to the dynamic ...
Source: The International Journal of Biochemistry and Cell Biology - March 1, 2024 Category: Biochemistry Authors: Manoswini Dash Bhawna Mahajan Ghulam Mehdi Dar Parameswar Sahu Sundeep Singh Saluja Source Type: research

An update on the cell-free DNA-derived methylome as a non-invasive biomarker for coronary artery disease
Int J Biochem Cell Biol. 2024 Feb 28:106555. doi: 10.1016/j.biocel.2024.106555. Online ahead of print.ABSTRACTCardiovascular diseases are the foremost contributor to global mortality, presenting a complex etiology and an expanding array of risk factors. Coronary artery disease characterized by atherosclerotic plaque build-up in the coronary arteries, imposes significant mortality and financial burdens, especially in low- and middle-income nations. The pathogenesis of coronary artery disease involves a multifaceted interplay of genetic, environmental, and epigenetic factors. Epigenetic regulation contributes to the dynamic ...
Source: The International Journal of Biochemistry and Cell Biology - March 1, 2024 Category: Biochemistry Authors: Manoswini Dash Bhawna Mahajan Ghulam Mehdi Dar Parameswar Sahu Sundeep Singh Saluja Source Type: research

The Application of Brain Organoid for Drug Discovery in Mitochondrial Diseases
Int J Biochem Cell Biol. 2024 Feb 27:106556. doi: 10.1016/j.biocel.2024.106556. Online ahead of print.ABSTRACTMitochondrial diseases are difficult to treat due to the complexity and multifaceted nature of mitochondrial dysfunction. Brain organoids are three-dimensional (3D) structures derived from human pluripotent stem cells designed to mimic brain-like development and function. Brain organoids have received a lot of attention in recent years as powerful tools for modeling human diseases, brain development, and drug screening. Screening compounds for mitochondrial diseases using brain organoids could provide a more physio...
Source: The International Journal of Biochemistry and Cell Biology - February 29, 2024 Category: Biochemistry Authors: Kristina Xiao Liang Source Type: research

The Application of Brain Organoid for Drug Discovery in Mitochondrial Diseases
Int J Biochem Cell Biol. 2024 Feb 27:106556. doi: 10.1016/j.biocel.2024.106556. Online ahead of print.ABSTRACTMitochondrial diseases are difficult to treat due to the complexity and multifaceted nature of mitochondrial dysfunction. Brain organoids are three-dimensional (3D) structures derived from human pluripotent stem cells designed to mimic brain-like development and function. Brain organoids have received a lot of attention in recent years as powerful tools for modeling human diseases, brain development, and drug screening. Screening compounds for mitochondrial diseases using brain organoids could provide a more physio...
Source: The International Journal of Biochemistry and Cell Biology - February 29, 2024 Category: Biochemistry Authors: Kristina Xiao Liang Source Type: research

Iron overload increases the sensitivity of endometriosis stromal cells to ferroptosis via a PRC2-independent function of EZH2
In this study, we examined the impact on ectopic endometrial stromal cells (EESCs) of iron overload and an inducer of ferroptosis. We found that the iron concentration in the ovarian endometriosis was much higher than control samples. Treatment of cultured EESCs with ferric ammonium citrate (FAC) increase the sensitivity to undergo ferroptosis. By analyzing the RNA-seq results, it was discovered that zeste 2 polycomb repressive complex 2 subunit (EZH2) was significantly downregulated in ferroptosis induced EESCs. Moreover, overexpression of EZH2 effectively prevented the induction of ferroptosis. In addition, the activity ...
Source: The International Journal of Biochemistry and Cell Biology - February 28, 2024 Category: Biochemistry Authors: Yong Luo Liping Li Qiwen Hu Ziyu Zhang Faying Liu Yongbao Peng Yang Zou Lina Chen Source Type: research

Iron overload increases the sensitivity of endometriosis stromal cells to ferroptosis via a PRC2-independent function of EZH2
In this study, we examined the impact on ectopic endometrial stromal cells (EESCs) of iron overload and an inducer of ferroptosis. We found that the iron concentration in the ovarian endometriosis was much higher than control samples. Treatment of cultured EESCs with ferric ammonium citrate (FAC) increase the sensitivity to undergo ferroptosis. By analyzing the RNA-seq results, it was discovered that zeste 2 polycomb repressive complex 2 subunit (EZH2) was significantly downregulated in ferroptosis induced EESCs. Moreover, overexpression of EZH2 effectively prevented the induction of ferroptosis. In addition, the activity ...
Source: The International Journal of Biochemistry and Cell Biology - February 28, 2024 Category: Biochemistry Authors: Yong Luo Liping Li Qiwen Hu Ziyu Zhang Faying Liu Yongbao Peng Yang Zou Lina Chen Source Type: research

PLA inhibits TNF- α-induced PANoptosis of prostate cancer cells through metabolic reprogramming
In conclusion, PLA inhibits TNF-α induced panapoptosis of prostate cancer cells through metabolic reprogramming, providing a new idea for targeted treatment of prostate cancer.PMID:38408537 | DOI:10.1016/j.biocel.2024.106554 (Source: The International Journal of Biochemistry and Cell Biology)
Source: The International Journal of Biochemistry and Cell Biology - February 26, 2024 Category: Biochemistry Authors: Yinghui Hao Fangmei Xie Jieyi He Chenqiong Gu Ying Zhao Wenfeng Luo Xiaoyu Song Jian Shen Li Yu Zeping Han Jinhua He Source Type: research