The International Journal of Biochemistry and Cell Biology 
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Int J Biochem Cell Biol. 2023 Nov 11:106494. doi: 10.1016/j.biocel.2023.106494. Online ahead of print.ABSTRACTMicroparticles (MPs) are a heterogeneous subpopulation of extracellular vesicles that originate from the plasma membranes of cells. There is increasing evidence that tumor-derived MPs (T-MPs) play a significant role in tumor progression and immune response in cancer. In our study, we found an increased secretion of MPs in osteosarcoma tissues obtained from metastatic patients. These T-MPs promoted polarization of M2-like macrophages and stimulated the migration and chemoresistance of osteosarcoma cells. Mechanistic...
Source: The International Journal of Biochemistry and Cell Biology - November 13, 2023 Category: Biochemistry Authors: Cui Li Feifan Xiang Yuqi Gong Yi Fu Ge Chen Zhi Wang Zhong Li Daiqing Wei Source Type: research
Tumor-derived microparticles promoted M2-like macrophages polarization to stimulate osteosarcoma progression
Int J Biochem Cell Biol. 2023 Nov 11:106494. doi: 10.1016/j.biocel.2023.106494. Online ahead of print.ABSTRACTMicroparticles (MPs) are a heterogeneous subpopulation of extracellular vesicles that originate from the plasma membranes of cells. There is increasing evidence that tumor-derived MPs (T-MPs) play a significant role in tumor progression and immune response in cancer. In our study, we found an increased secretion of MPs in osteosarcoma tissues obtained from metastatic patients. These T-MPs promoted polarization of M2-like macrophages and stimulated the migration and chemoresistance of osteosarcoma cells. Mechanistic...
Source: The International Journal of Biochemistry and Cell Biology - November 13, 2023 Category: Biochemistry Authors: Cui Li Feifan Xiang Yuqi Gong Yi Fu Ge Chen Zhi Wang Zhong Li Daiqing Wei Source Type: research
Tumor-derived microparticles promoted M2-like macrophages polarization to stimulate osteosarcoma progression
Int J Biochem Cell Biol. 2023 Nov 11:106494. doi: 10.1016/j.biocel.2023.106494. Online ahead of print.ABSTRACTMicroparticles (MPs) are a heterogeneous subpopulation of extracellular vesicles that originate from the plasma membranes of cells. There is increasing evidence that tumor-derived MPs (T-MPs) play a significant role in tumor progression and immune response in cancer. In our study, we found an increased secretion of MPs in osteosarcoma tissues obtained from metastatic patients. These T-MPs promoted polarization of M2-like macrophages and stimulated the migration and chemoresistance of osteosarcoma cells. Mechanistic...
Source: The International Journal of Biochemistry and Cell Biology - November 13, 2023 Category: Biochemistry Authors: Cui Li Feifan Xiang Yuqi Gong Yi Fu Ge Chen Zhi Wang Zhong Li Daiqing Wei Source Type: research
Tumor-derived microparticles promoted M2-like macrophages polarization to stimulate osteosarcoma progression
Int J Biochem Cell Biol. 2023 Nov 11:106494. doi: 10.1016/j.biocel.2023.106494. Online ahead of print.ABSTRACTMicroparticles (MPs) are a heterogeneous subpopulation of extracellular vesicles that originate from the plasma membranes of cells. There is increasing evidence that tumor-derived MPs (T-MPs) play a significant role in tumor progression and immune response in cancer. In our study, we found an increased secretion of MPs in osteosarcoma tissues obtained from metastatic patients. These T-MPs promoted polarization of M2-like macrophages and stimulated the migration and chemoresistance of osteosarcoma cells. Mechanistic...
Source: The International Journal of Biochemistry and Cell Biology - November 13, 2023 Category: Biochemistry Authors: Cui Li Feifan Xiang Yuqi Gong Yi Fu Ge Chen Zhi Wang Zhong Li Daiqing Wei Source Type: research
Tumor protein D52 (isoform 3) induces NF- κB - STAT3 mediated EMT driving neuroendocrine differentiation of prostate cancer cells
In this study, we report that TPD52 expression is positively associated with the emergence of neuroendocrine PCa (NEPC). With overexpression of TPD52 in LNCaP cells, we found neuroendocrine differentiation (NED) of cells in in-vitro and distinct NED features confirmed by NE markers neuron-specific enolase (NSE) and chromogranin A (CHR-A). Further, we investigated the molecular mechanisms involved in TPD52 mediated NED of PCa cells. We found that TPD52 activates the NF- κB - STAT3 axis for the induction of NED in LNCaP cells. Indeed, inhibition of NF-κB - STAT3 attenuated the progression of NED in TPD52 positive LNCaP cel...
Source: The International Journal of Biochemistry and Cell Biology - November 7, 2023 Category: Biochemistry Authors: K K Sruthi Sirisha Natani Ramesh Ummanni Source Type: research
Tumor protein D52 (isoform 3) induces NF- κB - STAT3 mediated EMT driving neuroendocrine differentiation of prostate cancer cells
In this study, we report that TPD52 expression is positively associated with the emergence of neuroendocrine PCa (NEPC). With overexpression of TPD52 in LNCaP cells, we found neuroendocrine differentiation (NED) of cells in in-vitro and distinct NED features confirmed by NE markers neuron-specific enolase (NSE) and chromogranin A (CHR-A). Further, we investigated the molecular mechanisms involved in TPD52 mediated NED of PCa cells. We found that TPD52 activates the NF- κB - STAT3 axis for the induction of NED in LNCaP cells. Indeed, inhibition of NF-κB - STAT3 attenuated the progression of NED in TPD52 positive LNCaP cel...
Source: The International Journal of Biochemistry and Cell Biology - November 7, 2023 Category: Biochemistry Authors: K K Sruthi Sirisha Natani Ramesh Ummanni Source Type: research
Tumor protein D52 (isoform 3) induces NF- κB - STAT3 mediated EMT driving neuroendocrine differentiation of prostate cancer cells
In this study, we report that TPD52 expression is positively associated with the emergence of neuroendocrine PCa (NEPC). With overexpression of TPD52 in LNCaP cells, we found neuroendocrine differentiation (NED) of cells in in-vitro and distinct NED features confirmed by NE markers neuron-specific enolase (NSE) and chromogranin A (CHR-A). Further, we investigated the molecular mechanisms involved in TPD52 mediated NED of PCa cells. We found that TPD52 activates the NF- κB - STAT3 axis for the induction of NED in LNCaP cells. Indeed, inhibition of NF-κB - STAT3 attenuated the progression of NED in TPD52 positive LNCaP cel...
Source: The International Journal of Biochemistry and Cell Biology - November 7, 2023 Category: Biochemistry Authors: K K Sruthi Sirisha Natani Ramesh Ummanni Source Type: research
Tumor protein D52 (isoform 3) induces NF- κB - STAT3 mediated EMT driving neuroendocrine differentiation of prostate cancer cells
In this study, we report that TPD52 expression is positively associated with the emergence of neuroendocrine PCa (NEPC). With overexpression of TPD52 in LNCaP cells, we found neuroendocrine differentiation (NED) of cells in in-vitro and distinct NED features confirmed by NE markers neuron-specific enolase (NSE) and chromogranin A (CHR-A). Further, we investigated the molecular mechanisms involved in TPD52 mediated NED of PCa cells. We found that TPD52 activates the NF- κB - STAT3 axis for the induction of NED in LNCaP cells. Indeed, inhibition of NF-κB - STAT3 attenuated the progression of NED in TPD52 positive LNCaP cel...
Source: The International Journal of Biochemistry and Cell Biology - November 7, 2023 Category: Biochemistry Authors: K K Sruthi Sirisha Natani Ramesh Ummanni Source Type: research
Tumor protein D52 (isoform 3) induces NF- κB - STAT3 mediated EMT driving neuroendocrine differentiation of prostate cancer cells
In this study, we report that TPD52 expression is positively associated with the emergence of neuroendocrine PCa (NEPC). With overexpression of TPD52 in LNCaP cells, we found neuroendocrine differentiation (NED) of cells in in-vitro and distinct NED features confirmed by NE markers neuron-specific enolase (NSE) and chromogranin A (CHR-A). Further, we investigated the molecular mechanisms involved in TPD52 mediated NED of PCa cells. We found that TPD52 activates the NF- κB - STAT3 axis for the induction of NED in LNCaP cells. Indeed, inhibition of NF-κB - STAT3 attenuated the progression of NED in TPD52 positive LNCaP cel...
Source: The International Journal of Biochemistry and Cell Biology - November 7, 2023 Category: Biochemistry Authors: K K Sruthi Sirisha Natani Ramesh Ummanni Source Type: research
ER-mitochondria contact sites in mitochondrial DNA dynamics, maintenance, and distribution
Int J Biochem Cell Biol. 2023 Nov 4:106492. doi: 10.1016/j.biocel.2023.106492. Online ahead of print.ABSTRACTMitochondria are central cellular metabolic hubs. Their function requires proteins encoded by nuclear DNA, but also mitochondrial DNA (mtDNA) whose maintenance is essential for the proper function of the organelle. Defective mtDNA maintenance and distribution are associated with mitochondrial diseases. mtDNA is organized into nucleo-protein complexes called nucleoids that dynamically move along the mitochondrial network and interact with each other. mtDNA replication and nucleoid distribution is an active process re...
Source: The International Journal of Biochemistry and Cell Biology - November 6, 2023 Category: Biochemistry Authors: Hema Saranya Ilamathi Marc Germain Source Type: research
ER-mitochondria contact sites in mitochondrial DNA dynamics, maintenance, and distribution
Int J Biochem Cell Biol. 2023 Nov 4:106492. doi: 10.1016/j.biocel.2023.106492. Online ahead of print.ABSTRACTMitochondria are central cellular metabolic hubs. Their function requires proteins encoded by nuclear DNA, but also mitochondrial DNA (mtDNA) whose maintenance is essential for the proper function of the organelle. Defective mtDNA maintenance and distribution are associated with mitochondrial diseases. mtDNA is organized into nucleo-protein complexes called nucleoids that dynamically move along the mitochondrial network and interact with each other. mtDNA replication and nucleoid distribution is an active process re...
Source: The International Journal of Biochemistry and Cell Biology - November 6, 2023 Category: Biochemistry Authors: Hema Saranya Ilamathi Marc Germain Source Type: research
Talin mechanotransduction in disease
Int J Biochem Cell Biol. 2023 Oct 30:106490. doi: 10.1016/j.biocel.2023.106490. Online ahead of print.ABSTRACTTalin protein (Talin 1/2) is a mechanosensitive cytoskeleton protein. The unique structure of the Talin plays a vital role in transmitting mechanical forces. Talin proteins connect the extracellular matrix to the cytoskeleton by linking to integrins and actin, thereby mediating the conversion of mechanical signals into biochemical signals and influencing disease progression as potential diagnostic indicators, therapeutic targets, and prognostic indicators of various diseases. Most studies in recent years have confi...
Source: The International Journal of Biochemistry and Cell Biology - November 1, 2023 Category: Biochemistry Authors: Yingzi Wang Haozhong Huang Huimin Weng Chunsen Jia Liao Bin Long Yang Fengxu Yu Yongmei Nie Source Type: research
CENPL accelerates cell proliferation, cell cycle, apoptosis, and glycolysis via the MEK1/2-ERK1/2 pathway in hepatocellular carcinoma
This study aimed to investigate the expression and clinical significance of CENPL in HCC, and explore its involvement in regulating HCC cell proliferation, apoptosis, cell cycle, and glycolysis both in vivo and in vitro. CENPL expression was analyzed in HCC and normal liver tissues using The Cancer Genome Atlas, Gene Expression Omnibus mining, real-time quantitative polymerase chain reaction, and immunohistochemistry. Functional assays were used to assess the role of CENPL in HCC cell proliferation, apoptosis, cell cycle, and glycolysis. The potential pathways underlying the regulatory effects of CENPL, as well as the expr...
Source: The International Journal of Biochemistry and Cell Biology - November 1, 2023 Category: Biochemistry Authors: Kun He Mengyi Xie Weifeng Hong Yonghe Li Yaolin Yin Xiaojin Gao Yi He Yu Chen Chuan You Jingdong Li Source Type: research
Talin mechanotransduction in disease
Int J Biochem Cell Biol. 2023 Oct 30:106490. doi: 10.1016/j.biocel.2023.106490. Online ahead of print.ABSTRACTTalin protein (Talin 1/2) is a mechanosensitive cytoskeleton protein. The unique structure of the Talin plays a vital role in transmitting mechanical forces. Talin proteins connect the extracellular matrix to the cytoskeleton by linking to integrins and actin, thereby mediating the conversion of mechanical signals into biochemical signals and influencing disease progression as potential diagnostic indicators, therapeutic targets, and prognostic indicators of various diseases. Most studies in recent years have confi...
Source: The International Journal of Biochemistry and Cell Biology - November 1, 2023 Category: Biochemistry Authors: Yingzi Wang Haozhong Huang Huimin Weng Chunsen Jia Liao Bin Long Yang Fengxu Yu Yongmei Nie Source Type: research
CENPL accelerates cell proliferation, cell cycle, apoptosis, and glycolysis via the MEK1/2-ERK1/2 pathway in hepatocellular carcinoma
This study aimed to investigate the expression and clinical significance of CENPL in HCC, and explore its involvement in regulating HCC cell proliferation, apoptosis, cell cycle, and glycolysis both in vivo and in vitro. CENPL expression was analyzed in HCC and normal liver tissues using The Cancer Genome Atlas, Gene Expression Omnibus mining, real-time quantitative polymerase chain reaction, and immunohistochemistry. Functional assays were used to assess the role of CENPL in HCC cell proliferation, apoptosis, cell cycle, and glycolysis. The potential pathways underlying the regulatory effects of CENPL, as well as the expr...
Source: The International Journal of Biochemistry and Cell Biology - November 1, 2023 Category: Biochemistry Authors: Kun He Mengyi Xie Weifeng Hong Yonghe Li Yaolin Yin Xiaojin Gao Yi He Yu Chen Chuan You Jingdong Li Source Type: research
