The Ethics of Precision Rationing: Human Genetics and the Need for Debate on Stratifying Access to Medication
Rising prices for new, transformative therapies are challenging health systems around the world, leading many payers and providers to begin rationing access to treatments, even in the countries that have been most resistant to doing so. This is the case for direct-acting antivirals (DAAs) for the treatment of hepatitis C virus (HCV). However, little attention has been paid to the increasing role that human genetics might play in rationing decisions. Researchers have already proposed that genetic markers associated with spontaneous HCV clearance could be used to restrict DAA access for some patients, although treatment woul...
Source: Public Health Genomics - June 9, 2020 Category: Genetics & Stem Cells Source Type: research
Publisher's Note
Public Health Genomics 2020;23:1 (Source: Public Health Genomics)
Source: Public Health Genomics - May 12, 2020 Category: Genetics & Stem Cells Source Type: research
At a Moment ’s Notice: Community Advisory Board Perspectives on Biobank Communication to Supplement Broad Consent
Conclusion:Our findings contribute to the emerging literature on community engagement in biobanking. Additional communication with biobank contributors can serve a variety of value-based objectives to supplement broad consent. Design of communication efforts by biobanks can be improved by CAB members ’ anticipation of the unintended consequences of additional contact with contributors. CAB members’ holistic interpretation of communication efforts suggests that biobank leadership considers all communication options as part of a more comprehensive communications strategy.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - May 12, 2020 Category: Genetics & Stem Cells Source Type: research
The rs2236609 Polymorphism Is Related to Increased Risk Susceptibility of Atrial Fibrillation
Conclusion: Our results showed a significant increase in AF risk in people carrying the A allele, while the G allele might be considered as a protective allele.Public Health Genomics 2020;23:54 –58 (Source: Public Health Genomics)
Source: Public Health Genomics - April 21, 2020 Category: Genetics & Stem Cells Source Type: research
In Different Voices: The Views of People with Disabilities about Return of Results from Precision Medicine Research
Conclusion: Insofar as return of results from PMR may impact translational efforts, it is important to better understand the role of sociomedical marginalization in decisions about return of results from PMR and to develop strategies to address existing barriers.Public Health Genomics 2020;23:42 –53 (Source: Public Health Genomics)
Source: Public Health Genomics - April 15, 2020 Category: Genetics & Stem Cells Source Type: research
Return of Research-Related Genetic Test Results and Genetic Discrimination Concerns: Facilitators and Barriers of Genetic Research Participation in Diverse Groups
Conclusions: Policies that prohibit the return of results and do not address genetic discrimination concerns may contribute to a greater underrepresentation of diverse groups in genetic research.Public Health Genomics 2020;23:59 –68 (Source: Public Health Genomics)
Source: Public Health Genomics - April 14, 2020 Category: Genetics & Stem Cells Source Type: research
Higher Odds of Type 2 Diabetes for Some Blood Groups
Conclusion: According to the results of this study, the odds of type 2 diabetes for people in blood group A was higher than for those in other blood groups. It is recommended that blood group A be considered as a risk factor in the screening of type 2 diabetes.Public Health Genomics 2020;23:37 –41 (Source: Public Health Genomics)
Source: Public Health Genomics - April 6, 2020 Category: Genetics & Stem Cells Source Type: research
Illustrating Cancer Risk: Patient Risk Communication Preferences and Interest regarding a Novel < b > < i > BRCA1/2 < /i > < /b > Genetic Risk Modifier Test
Conclusions: Women withBRCA1/2 mutations could be highly receptive to GRMT, and the minimal amount of necessary information to be included in result risk communication materials includes graphical and verbal estimates of future cancer risk. Findings will inform clinical translation of GRMT in a manner consistent with patients ’ preferences.Public Health Genomics 2020;23:6 –19 (Source: Public Health Genomics)
Source: Public Health Genomics - March 19, 2020 Category: Genetics & Stem Cells Source Type: research
Generic Cost-Effectiveness Models: A Proof of Concept of a Tool for Informed Decision-Making for Public Health Precision Medicine
Conclusion: This proof on concept demonstrates the feasibility of generic models to provide useful PM economic evidence, supporting their use as a pragmatic and timely approach to address a growing need.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - June 12, 2019 Category: Genetics & Stem Cells Source Type: research
Multiple Stakeholder Views on Data Sharing in a Biobank in an Integrated Healthcare Delivery System: Implications for Biobank Governance
Conclusions: The study results were considered in the development of RPGEH data governance and motivated the inclusion of KPNC Community Advisory Panel members and ELSI experts on committees that evaluate data access proposals. Our findings can help inform other biobanks going through similar processes developing data sharing and access policies.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - June 5, 2019 Category: Genetics & Stem Cells Source Type: research
Understanding Factors Associated with Uptake of < b > < i > BRCA1/2 < /i > < /b > Genetic Testing < b > < i > < /i > < /b > among Orthodox Jewish Women in the USA Using a Mixed-Methods Approach
Conclusion: In order to increase the uptake ofBRCA1/2 genetic testing among the Orthodox Jewish population, it is crucial to understand religious and cultural factors, such as stigma and effect on marriageability, and engage religious leaders in raising awareness within the community.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - June 4, 2019 Category: Genetics & Stem Cells Source Type: research
Lifestyle Interventions for Weight Control Modified by Genetic Variation: A Review of the Evidence
Conclusion: Gene-lifestyle interaction studies on the same candidate gene in different populations have reported information which is challenging to interpret. Thus, it is difficult to arrive at a particular model for a strategy on weight management at this point in time. Most of the intervention studies focus on the effect of variants of a single candidate gene on weight loss. Further evidence from large-scale studies is necessary to assess the effect of multiple candidate genes to compute a gene score that could be used in a model intervention programme. Our review suggests that a healthy lifestyle with a balanced diet a...
Source: Public Health Genomics - May 22, 2019 Category: Genetics & Stem Cells Source Type: research
The Creation and Management of Innovations in Healthcare and ICT: The European and African Experience
The purpose of the study was to gain new insights into innovation systems by comparing state-of-the-art of existing approaches of innovation creation and innovation management in healthcare and ICT. It is unique, in that it compares countries in Africa with countries in Europe in order to identify similarities and differences regarding the creation and management of innovations. The main similarity is that early dialogue between different stakeholders was underrepresented during the whole innovation process in all countries. Our results also indicated that the various stakeholders often work in silos. The main difference w...
Source: Public Health Genomics - May 14, 2019 Category: Genetics & Stem Cells Source Type: research
Psychological Impact of Learning < b > < i > CDKN2A < /i > < /b > Variant Status as a Genetic Research Result
Conclusions: Return of IRR in conjunction with cancer prevention counseling led to low levels of test-specific distress and uncertainty among carriers. No other adverse psychological outcomes were observed.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - April 18, 2019 Category: Genetics & Stem Cells Source Type: research
Editorial Commentary on “Psychological Impact of Learning < b > < i > CDKN2A < /i > < /b > Variant Status as a Genetic Research Result ” by Zhu et al.
Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - April 18, 2019 Category: Genetics & Stem Cells Source Type: research
