Comprehension and Data-Sharing Behavior of Direct-To-Consumer Genetic Test Customers
Conclusions: Most of the subjects were able to correctly interpret the test cases, yet a majority did not share their results with a health-care professional. As the market for DTC genetic testing grows, test comprehension will become more critical. Involving more health professionals in this process may be necessary to ensure proper interpretations.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - March 8, 2016 Category: Genetics & Stem Cells Source Type: research
Genomics Politics through Space and Time: The Case of Bioinformatics in Brazil
The emergence of scientific disciplines, as well as the policies aimed to steer them, have geographical implications. This becomes visible in areas such as genomics and related fields. In this paper, the relation between scientific evolution, political decisions and geographical configuration is studied. The recent formation of bioinformatics in Brazil is focused on. The study involves an analysis of data collected on the website of CNPq, a funding agency attached to the Ministry of Science and Technology. Furthermore, I conducted fieldwork in four cities, interviewing 15 bioinformaticians. In the history of Brazilian bioi...
Source: Public Health Genomics - February 19, 2016 Category: Genetics & Stem Cells Source Type: research
What You Don't Know: Improving Family Health History Knowledge among Multigenerational Families of Mexican Origin
Conclusions: Limited FHH knowledge was noted among those born in the US and younger participants, representing a key population to reach with intervention efforts. The intervention effect suggests that ‘less is more', indicating the potential for too much information to limit health education program effectiveness.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - February 9, 2016 Category: Genetics & Stem Cells Source Type: research
Utilizing Genomics through Family Health History with the Theory of Planned Behavior: Prediction of Type 2 Diabetes Risk Factors and Preventive Behavior in an African American Population in Florida
Conclusion: The lack of perceived risk in this population shows the importance of not only knowing one's risk factors but translating those risk factors to a more personalized form that fits into the current lifestyle of the individual in a meaningful way.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - February 5, 2016 Category: Genetics & Stem Cells Source Type: research
Perspectives on Translational Genomics and Public Health in India
It is now recognized worldwide that anticipation and prevention of diseases have significant advantages for the health and healthy ageing of the population. Early recognition of the disease in a vulnerable population such as in children aged 60 years enhances our preparedness for any eventualities and future burden of the diseases to society. It is also recognized that current public health practices alone cannot bring about the desired outcome. When tackling public health-related issues, such problems must be recognized and state-of-the-art principles and innovations from genomic sciences, information technologies, and me...
Source: Public Health Genomics - December 19, 2015 Category: Genetics & Stem Cells Source Type: research
Contents Vol. 18, No. 6, 2015
Public Health Genomics 2015;18:I-IV (Source: Public Health Genomics)
Source: Public Health Genomics - December 16, 2015 Category: Genetics & Stem Cells Source Type: research
Title Page / Table of Contents
Public Health Genomics 2015;18:321-324 (Source: Public Health Genomics)
Source: Public Health Genomics - December 16, 2015 Category: Genetics & Stem Cells Source Type: research
Author and Subject Index Vol. 18, No. 6, 2015
Public Health Genomics 2015;18:396 (Source: Public Health Genomics)
Source: Public Health Genomics - December 16, 2015 Category: Genetics & Stem Cells Source Type: research
Polymorphism of Metallothionein 2A Modifies Lead Body Burden in Workers Chronically Exposed to the Metal
Lead (Pb) is a metal that accumulates in the human body, inducing several adverse health effects. One of the proteins responsible for the distribution of metal in the body is metallothionein (MT), which is expressed by different genes, and it is supposed that genetic variation in the genes that encode MTs may affect the Pb body burden. The present study aimed to evaluate the genetic effects of the polymorphism of MT2A (single nucleotide polymorphism rs10636; C#x2192;G) on blood Pb levels (BLL) of workers from car battery factories who are chronically exposed to the metal. In total, 221 men participated in the study; genomi...
Source: Public Health Genomics - November 24, 2015 Category: Genetics & Stem Cells Source Type: research
Current Status of the Management of Hereditary Breast and Ovarian Cancer in Asia: First Report by the Asian BRCA Consortium
Conclusions: The Asian BRCA Consortium reports the current disparities in genetic services for HBOC in Asia and urges the policy makers, healthcare sectors and researchers to address the limitations in HBOC management.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - November 19, 2015 Category: Genetics & Stem Cells Source Type: research
Mothers' Views on Longer Storage of Neonatal Dried Blood Spots for Specific Secondary Uses
Conclusion: Mothers indicate support of several secondary uses and prolonged storage of DBS but report a low awareness of current storage and secondary use policies. Efforts must be made to involve parents as key stakeholders in DBS policies. This could be achieved through a parent-led advisory structure.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - November 19, 2015 Category: Genetics & Stem Cells Source Type: research
Charting the Course for a New Cancer Clinical Research Culture
The convergence of new biological insights from sequencing, digital technologies and advanced bioinformatics tools are creating new opportunities to advance cancer care for individual patients. Fully realising this potential will require the integration and alignment of multiple stakeholders across the healthcare system. To increase the speed in which personalised medicine discoveries are translated into clinical practice and accessible to patients requires appropriately conducted clinical research with input and usage by patients, healthcare providers, regulatory authorities and policy makers. These stakeholders need to a...
Source: Public Health Genomics - November 19, 2015 Category: Genetics & Stem Cells Source Type: research
Establishing the Evidence Bar for Molecular Diagnostics in Personalised Cancer Care
While personalised cancer medicine holds great promise, targeting therapies to the biological characteristics of patients is limited by the number of validated biomarkers currently available. The implementation of biomarkers has undergone many challenges with few biomarkers reaching cancer patients in the clinic. There have been many biomarkers that have been published and claimed to be therapeutically useful, but few become part of the clinical decision-making process due to technical, validation and market access issues. To reduce this attrition rate, there is a significant need for policy makers and reimbursement agenci...
Source: Public Health Genomics - November 16, 2015 Category: Genetics & Stem Cells Source Type: research
Clinical Trials, Data Protection and Patient Empowerment in the Era of the New EU Regulations
Cancer clinical trials and, in general, cancer clinical research by definition need a multi-modality approach. It is not enough to discover and register new drugs. To get cancer under control requires us to perform complex clinical studies that integrate drugs, companion diagnostics, new or improved surgical procedures and new radiotherapy approaches as well as, most importantly, to integrate all available information. This includes biological material and, of increasing importance, large amounts of data using big data technologies. To personalise treatment, genetic data are more and more frequently used. Therefore, the ge...
Source: Public Health Genomics - November 13, 2015 Category: Genetics & Stem Cells Source Type: research
Integrating Personalized Medicine in the Canadian Environment: Efforts Facilitating Oncology Clinical Research
There is currently a rapid evolution of clinical practices based on the introduction of patient stratification and molecular diagnosis that is likely to improve health outcomes. Building on a strong research base, complemented by strong support from clinicians and health authorities, the oncology field is at the forefront of this evolution. Yet, clinical research is still facing many challenges that need to be addressed in order to conduct necessary studies and effectively translate medical breakthroughs based on personalized medicine into standards of care. Leveraging its universal health care system and on resources deve...
Source: Public Health Genomics - November 13, 2015 Category: Genetics & Stem Cells Source Type: research
