Understanding of Inheritance and Genetic Variation Assessed through the Use of an Engaging Real-Life Survey
Conclusions: People recognize the basic concepts of heritability but struggle with real-life interpretations and more nuanced concepts of heredity.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - December 8, 2020 Category: Genetics & Stem Cells Source Type: research
Healthcare Professional Clinical Actions following Nutrigenomics Testing in Practice
Conclusion: Early HCP adopters of NGT utilize the test results to provide genetic-based dietary recommendations to patients. Clinical action after NGT currently appears to be driven by HCP years in practice, but HCP personal use of GT may also be a factor.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - December 4, 2020 Category: Genetics & Stem Cells Source Type: research
Association between < b > < i > SIRT6 < /i > < /b > Methylation and Human Longevity in a Chinese Population
Conclusion: The low level ofSIRT6 methylation may be a potential protective factor of Chinese longevity.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - November 25, 2020 Category: Genetics & Stem Cells Source Type: research
Genetics-Related Activities in Everyday Practice of Family Physicians in Slovenia
Conclusions: Slovenian family physicians commonly encounter patients with genetic conditions but are not confident in their ability to carry out basic medical genetic tasks. Therefore, additional education is necessary.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - November 23, 2020 Category: Genetics & Stem Cells Source Type: research
Four Actionable Bottlenecks and Potential Solutions to Translating Psychiatric Genetics Research: An Expert Review
Conclusions: These entwined bottlenecks are examined with one another. Awareness of these bottlenecks can inform stakeholders who work to translate and/or utilize psychiatric genetic information. Potential solutions include utilizing nonlinear translational frameworks as well as a wider array of psychiatric genetic information (e.g., family history and gene-environment interplay) in this area of research, expanding which psychiatric disorders are considered for translation, and when possible, conducting original research. Researchers are urged to consider how their research is translational in the context of the frameworks...
Source: Public Health Genomics - November 4, 2020 Category: Genetics & Stem Cells Source Type: research
< b > < i > CYP24A1 < /i > < /b > rs1570669 Variant Has a Protective Effect against Tumors of the Urinary System
Conclusions:CYP24A1 rs1570669 may play an important role in the susceptibility of tumors of the urinary system and renal cancer.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - October 28, 2020 Category: Genetics & Stem Cells Source Type: research
Misinterpretation of Hereditary Breast Cancer Risk and Its Association with Information Sharing Motives among Women at Low Likelihood of Carrying a < b > < i > BRCA1/2 < /i > < /b > Mutation
Conclusions: As family history-based screening for hereditary breast cancer is broadly implemented, the communication needs of the majority of women who will be unlikely of carrying aBRCA1/2 mutation must be considered. The motives of women who misinterpreted the implications of this result for breast cancer risk suggest the possibility that miscommunication could be spread to the broader family network.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - October 27, 2020 Category: Genetics & Stem Cells Source Type: research
SNPs in Sites for DNA Methylation, Transcription Factor Binding, and miRNA Targets Leading to Allele-Specific Gene Expression and Contributing to Complex Disease Risk: A Systematic Review
Conclusion: The systematic review provides evidence for the interplay between genetic and epigenetic risk factors through allele-specific gene expression in various complex multifactorial diseases.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - September 23, 2020 Category: Genetics & Stem Cells Source Type: research
Merkel Cell Polyomavirus Gene Expression and Mutational Analysis of Large Tumor Antigen in Non-Merkel Cell Carcinoma Tumors of Iranian Patients
Conclusion: Considering the important role of the LT-Ag in the pathogenicity of MCPyV, non-synonymous mutations compared with the reference proteins triggered relevant amino acid substitutions. Overall, the results showed no tumor-associated mutations in the LT-Ag sequence of MCPyVs from positive samples.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - September 23, 2020 Category: Genetics & Stem Cells Source Type: research
Implementing Cancer Genomics in State Health Agencies: Mapping Activities to an Implementation Science Outcome Framework
Conclusion: State health agencies can use the Doyle et al. [Genet Med. 2018;20(9):995 –1003] performance objectives and outcome measures to evaluate proposed and ongoing activities. By demonstrating whether activities result in improved outcomes, state health agencies can build the evidence for the implementation of cancer genomics activities.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - September 17, 2020 Category: Genetics & Stem Cells Source Type: research
Factors Influencing Participation in Biospecimen Research among Parents of Youth with Mental Health Conditions
Conclusions: Participants were eager to participate as long as the research process involved trust, clarity, and flexibility. Future research involving youth with mental health conditions would benefit from implementing multimodal strategies for recruitment and data collection and sharing knowledge gained by the research with study participants.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - July 22, 2020 Category: Genetics & Stem Cells Source Type: research
A Genomic Test for Colorectal Cancer Risk: Is This Acceptable and Feasible in Primary Care?
Conclusions: Genomic testing for CRC risk in primary care is acceptable and likely feasible. Further development of the risk assessment intervention could strengthen the impact on screening behaviour.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - July 20, 2020 Category: Genetics & Stem Cells Source Type: research
Assessing the Intention to Provide Human Genetic Resources: An Explanatory Model
Conclusions: The results of our study provide insights into how to improve people ’s intention to provide human genetic resources. We also proposed ways to protect such resources globally.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - July 17, 2020 Category: Genetics & Stem Cells Source Type: research
Variations in the Referral Pattern for Genetic Counseling of Patients with Early-Onset Breast Cancer: A Population-Based Study in Southern Sweden
Swedish national breast cancer guidelines recommend that all women diagnosed with breast cancer (BC) at the age of 35 years or younger should be referred to their regional oncogenetic clinic for genetic counseling and testing, regardless of family history of cancer. The main objective of this study was to evaluate whether place of residence at BC diagnosis and treating hospital were associated with the fact that not all BC patients diagnosed at ≤35 years in the southern part of Sweden have attended genetic counseling and testing. Between 2000 and 2013, 279 women in the South Swedish Health Care Region were diagnosed with...
Source: Public Health Genomics - July 8, 2020 Category: Genetics & Stem Cells Source Type: research
< b > < i > NT5C2 < /i > < /b > Gene Polymorphisms and the Risk of Coronary Heart Disease
Conclusion: This study reports the association ofNT5C2 gene variants and CHD susceptibility in the Chinese Han population. Especially,NT5C2 rs2148198 was significantly associated with CHD risk in the subgroups of males, hypertension, and diabetes.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - June 15, 2020 Category: Genetics & Stem Cells Source Type: research
