Which Test Is Best? A Cluster-Randomized Controlled Trial of a Risk Calculator and Recommendations on Colorectal Cancer Screening Behaviour in General Practice
Conclusion: An online CRC risk calculator with risk-based screening recommendations increased RAS in high-risk participants and improved screening uptake overall within a 12-month follow-up period. Such tools may be useful for facilitating the uptake of risk-based screening guidelines.Public Health Genomics 2022;25:193 –208 (Source: Public Health Genomics)
Source: Public Health Genomics - October 4, 2022 Category: Genetics & Stem Cells Source Type: research
Which Test Is Best? A Cluster-Randomized Controlled Trial of a Risk Calculator and Recommendations on Colorectal Cancer Screening Behaviour in General Practice
Conclusion: An online CRC risk calculator with risk-based screening recommendations increased RAS in high-risk participants and improved screening uptake overall within a 12-month follow-up period. Such tools may be useful for facilitating the uptake of risk-based screening guidelines.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - October 4, 2022 Category: Genetics & Stem Cells Source Type: research
Knowledge and Attitudes about Privacy and Secondary Data Use among African-Americans Using Direct-to-Consumer Genetic Testing
Conclusion: This study found that African-American consumers of DTC GT had a positive outlook about genetic testing and were open to research and some nonresearch uses, provided that they were able to give informed consent. Participants in this study had little knowledge of company practices regarding secondary uses. Compared to an earlier cohort of European American participants, African-American participants expressed more concerns about medical and law enforcement communities ’ use of data and more reference to community engagement.Public Health Genomics 2022;25:164 –173 (Source: Public Health Genomics)
Source: Public Health Genomics - September 27, 2022 Category: Genetics & Stem Cells Source Type: research
Knowledge and Attitudes about Privacy and Secondary Data Use among African-Americans Using Direct-to-Consumer Genetic Testing
Conclusion: This study found that African-American consumers of DTC GT had a positive outlook about genetic testing and were open to research and some nonresearch uses, provided that they were able to give informed consent. Participants in this study had little knowledge of company practices regarding secondary uses. Compared to an earlier cohort of European American participants, African-American participants expressed more concerns about medical and law enforcement communities ’ use of data and more reference to community engagement.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - September 27, 2022 Category: Genetics & Stem Cells Source Type: research
Diverse Parental Perspectives of the Social and Educational Needs for Expanding Newborn Screening through Genomic Sequencing
Conclusions: Parents anticipate value in expanded NBS through genomic sequencing both for medical and nonmedical/personal utility. In order to successfully implement expanded NBS, prospective parents need more and earlier education about the process. These needs may differ by language and culture. Information needs to be easily accessible and to be curated by appropriate experts and stakeholders, including parents representative of the diversity of the USA.Public Health Genomics 2022;25:185 –192 (Source: Public Health Genomics)
Source: Public Health Genomics - September 15, 2022 Category: Genetics & Stem Cells Source Type: research
Diverse Parental Perspectives of the Social and Educational Needs for Expanding Newborn Screening through Genomic Sequencing
Conclusions: Parents anticipate value in expanded NBS through genomic sequencing both for medical and nonmedical/personal utility. In order to successfully implement expanded NBS, prospective parents need more and earlier education about the process. These needs may differ by language and culture. Information needs to be easily accessible and to be curated by appropriate experts and stakeholders, including parents representative of the diversity of the USA.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - September 15, 2022 Category: Genetics & Stem Cells Source Type: research
Associations between < b > < i > TNFAIP3 < /i > < /b > Polymorphisms and Rheumatoid Arthritis: A Systematic Review and Meta-Analysis Update with Trial Sequential Analysis
Conclusion:TNFAIP3 rs2230926 and rs5029937 polymorphisms are associated with RA susceptibility in European and Asian populations. However, the data were not stratified by parameters such as rheumatoid factor status, disease activity, or environmental variables.Public Health Genomics 2022;25:174 –184 (Source: Public Health Genomics)
Source: Public Health Genomics - September 12, 2022 Category: Genetics & Stem Cells Source Type: research
Associations between < b > < i > TNFAIP3 < /i > < /b > Polymorphisms and Rheumatoid Arthritis: A Systematic Review and Meta-Analysis Update with Trial Sequential Analysis
Conclusion:TNFAIP3 rs2230926 and rs5029937 polymorphisms are associated with RA susceptibility in European and Asian populations. However, the data were not stratified by parameters such as rheumatoid factor status, disease activity, or environmental variables.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - September 12, 2022 Category: Genetics & Stem Cells Source Type: research
Communicating Precision Medicine Research: Multidisciplinary Teams and Diverse Communities
Conclusion: The precision medicine research definition and case examples can be used as planning tools to establish a shared understanding of the scope of precision medicine research across multidisciplinary teams and with the diverse communities in which precision medicine research will take place. This shared understanding is vital for successful and equitable progress in precision medicine.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - August 23, 2022 Category: Genetics & Stem Cells Source Type: research
Evaluating the Effectiveness of a Telehealth Cancer Genetics Program: A < b > < i > BRCA < /i > < /b > Pilot Study
Conclusions: TheBRCA founder mutation rate in a low-risk AJ population was significantly lower than the previously established AJ rate of 1 in 40. It was also determined that a telehealth model for a cancer genetics program is effective and acceptable to the population tested. This study established interest in broader cancer genetic testing through a telehealth platform and suggested that testing may be successful in the Jewish community at a national level and potentially in other populations, provided that patient education and genetic counseling are adequately incorporated.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - August 9, 2022 Category: Genetics & Stem Cells Source Type: research
Screening of Serum miRNAs as Diagnostic Biomarkers for Lung Cancer Using the Minimal-Redundancy-Maximal-Relevance Algorithm and Random Forest Classifier Based on a Public Database
Conclusion: By and large, the 5 feature miRNAs screened here were anticipated to be effective biomarkers for lung cancer.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - August 2, 2022 Category: Genetics & Stem Cells Source Type: research
An Electronic Health Record Tool Increases Genetic Counseling Referral of Individuals at Hereditary Cancer Risk: An Intervention Study
Conclusion: Genetic counseling referral of individuals at hereditary cancer risk was increased by use of an EHR-integrated tool. These findings add evidence for the benefit of clinical decision support for cancer genetic risk screening in primary care.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - July 27, 2022 Category: Genetics & Stem Cells Source Type: research
“A Gift to My Family for Their Future”: Attitudes about Genetic Research Participation
Conclusions: To promote broad participation in genetic research, it is important that recruitment materials address the primary motivators for genetic research participation, including altruism and the potential use of results for personal decision-making. Study materials should also address concerns about possible misuse of genetic information and fears over potential data breaches.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - May 11, 2022 Category: Genetics & Stem Cells Source Type: research
A Case-Control Study of the Luteinizing Hormone Level in Luteinizing Hormone Receptor Gene (rs2293275) Polymorphism in Polycystic Ovarian Syndrome Females
Conclusion: LHCGR (rs2293275) GA and GG genetic variants could modulate the hormonal levels of PCOS LH levels and the LH/FSH ratio and associated with hirsutism, oligomenorrhea, BMI, and LH/FSH ratio as risk factors.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - March 29, 2022 Category: Genetics & Stem Cells Source Type: research
Translational Science, DNA Commercialization, and Informed Consent: The Need for Specific Terminology, Insights from a Review of H3Africa Projects
In the past decade, there has been an acceleration in genomic research, its applications, and its translation into healthcare products and services for the benefit of public health. These advances are critical to realizing the potential of genomic research for facilitating improved health and disease prevention, diagnosis, and treatment. Despite its tremendous opportunities, the dynamic and increasingly global landscape of genomic research commercialization has been accompanied by a variety of ethical challenges and concerns. The potential for unauthorized use of DNA samples from African people to develop a DNA chip amplif...
Source: Public Health Genomics - January 25, 2022 Category: Genetics & Stem Cells Source Type: research
