Role of Metabolic Risk Factors, Family History, and Genetic Polymorphisms (PPAR γ and TCF7L2) on Type 2 Diabetes Mellitus Risk in an Asian Indian Population
Conclusion: This study leads to the conclusion that Asian Indian women population based in Kolkata, India, are ethnically and genetically predisposed to the risk factors of diabetes through FHD, which is reflected in their gestational phase, and it has a significant implication on their birth outcomes.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - March 30, 2021 Category: Genetics & Stem Cells Source Type: research
Genetic Testing in Natural History Studies: A Review of the Regulatory and Legal Landscape
Conclusion: Lack of harmonization of regulations governing NH studies with molecular biomarker collection contributes to the operational complexity of conducting multinational studies in orphan and rare diseases. A set of harmonized international guidelines for these studies would improve efficiency, and this may be on the horizon with the recent adaption of International Conference on Harmonisation (ICH) guideline E18.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - March 23, 2021 Category: Genetics & Stem Cells Source Type: research
Stakeholders ’ Interest and Attitudes toward Genomic Medicine and Pharmacogenomics Implementation in the United Arab Emirates: A Qualitative Study
Conclusions: Implementing the Mendelow ’s model will allow the systematic strategy for implementing genomic medicine in UAE. This can be achieved by engaging the key players (promoters and defenders) as well as engaging and satisfying the latent stakeholder.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - March 17, 2021 Category: Genetics & Stem Cells Source Type: research
Investigation of the Association between 45 Tag SNPs and Type 2 Diabetes Mellitus in Han Chinese Adults: A Prospective Cohort Study
Conclusion: Variants of the PTPRD, CDC123, and MC4R genes were associated with the T2DM incidence in a rural Han Chinese population.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - March 11, 2021 Category: Genetics & Stem Cells Source Type: research
Motivating and Discouraging Factors for Bipolar Patient Participation in Genomic Research
Conclusions: Black/African American participants with bipolar disorder were more likely to express concerns about DNA and biobank research. But while race was a contributing factor to support or opposition to biobanking for bipolar disorder research, more salient was insufficient positive motivation. These results highlight the need to emphasize contemporary safeguards on DNA research and biobanking as an ethical duty and to identify the need for community-based educational interventions to promote a greater understanding of the positive benefits to motivate increased research participation.Public Health Genomics (Source: ...
Source: Public Health Genomics - March 3, 2021 Category: Genetics & Stem Cells Source Type: research
Secondary Data Usage in Direct-to-Consumer Genetic Testing: To What Extent Are Customers Aware and Concerned?
Conclusion: When exposed to new information on secondary uses of data, customers express concerns and a desire to improve consent with transparency, more opt-out options, improved readability, and more information on future uses and potential risks from direct-to-consumer companies. Effective ways to improve readership about the secondary use, risk of use, and protection of customer data should be investigated and the findings implemented by DTC companies to protect public trust in these practices.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - February 26, 2021 Category: Genetics & Stem Cells Source Type: research
Experiences of Latino Participants Receiving Neutral Genomic Screening Results: A Qualitative Study
Discussion: This is one of the first studies to examine the experiences of Latino individuals receiving genomic screening results. Our results suggest that many Latino patients in the US see value in genomic screening and have limited concerns about its potential to cause harm. These results inform ongoing efforts to increase the availability of genomic medicine to underrepresented populations and add to our understanding of sociocultural drivers in the adoption of precision medicine.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - February 16, 2021 Category: Genetics & Stem Cells Source Type: research
Teenagers and Precision Psychiatry: A Window of Opportunity
Conclusion: Educating teenagers about gene-environment interactions may help facilitate the translational efforts of precision psychiatry. Research with teenagers across racial/ethnic groups, especially those with family histories, is needed to better understand the factors that impact teenagers ’ empowerment in psychiatric genomic settings and to identify measures, including the best enablers of empowerment (e.g., educators, parents), which would allow them to reap the benefits of precision psychiatry.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - January 27, 2021 Category: Genetics & Stem Cells Source Type: research
Ethical Aspects of Genotype Disclosure: Perceptions of Participants in a Nutrigenetic Study in Finland
Conclusions: Careful distribution of information before a nutrigenetic study supports understanding and reduces concerns of genetic susceptibility. In Finland, strong basic education is likely to have strengthened the trust in research process.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - January 22, 2021 Category: Genetics & Stem Cells Source Type: research
Contents Vol. 23, 2020
Public Health Genomics 2020;23:I –IV (Source: Public Health Genomics)
Source: Public Health Genomics - January 19, 2021 Category: Genetics & Stem Cells Source Type: research
Impact of Previous Genetic Counseling and Objective Numeracy on Accurate Interpretation of a Pharmacogenetics Test Report
Conclusion: We found that numeracy had a significant impact on correct interpretation of PGx test reports. Because many individuals in the USA have low numeracy levels, it is extremely important that patients do not make their own medication management decision based on the test results and that they consult with their physicians about their PGx testing. The importance of consultation and discussion with providers about results should be emphasized on the test report.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - January 14, 2021 Category: Genetics & Stem Cells Source Type: research
Challenges and Opportunities for Communication about the Role of Genomics in Public Health
Despite growing awareness about the potential for genomic information to improve population health, lingering communication challenges remain in describing the role of genomics in public health programs. Identifying and addressing these challenges provide an important opportunity for appropriate communication to ensure the translation of genomic discoveries for public health benefits. In this commentary, we describe 5 common communication challenges encountered by the Centers for Disease Control and Prevention ’s Office of Genomics and Precision Public Health based on over 20 years of experience in the field. These inclu...
Source: Public Health Genomics - January 14, 2021 Category: Genetics & Stem Cells Source Type: research
Genetic Variation and Evolution of the 2019 Novel Coronavirus
Conclusion: Observations of this study provided evidence of the genetic diversity and rapid evolution of SARS-CoV-2 as well as other human and animal coronaviruses.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - January 6, 2021 Category: Genetics & Stem Cells Source Type: research
Comparative Genome-Wide Characterization of Microsatellites in < b > < i > Candida albicans < /i > < /b > and < b > < i > Candida dubliniensis < /i > < /b > Leading to the Development of Species-Specific Marker
Conclusion: The features of microsatellite distribution in the two species ’ genomes revealed that it is probably not conserved in the genusCandida. Data generated in this article could be used for comparative genome mapping and understanding the distribution of microsatellites and genome structure between these closely related and phenotypically misidentified species and may provide a foundation for the development of a new set of species-specific microsatellite markers. Here, we also report a novel microsatellite-based marker forC. dubliniensis-specific identification.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - January 5, 2021 Category: Genetics & Stem Cells Source Type: research
Screening for < b > < i > GJB2 < /i > < /b > -R143W-Associated Hearing Impairment: Implications for Health Policy and Practice in Ghana
Genetic factors significantly contribute to the burden of hearing impairment (HI) in Ghana as there is a high carrier frequency (1.5%) of the connexin 26 gene founder variantGJB2-R143W in the healthy Ghanaian population.GJB2-R143W mutation accounts for nearly 26% of causes in families segregating congenital non-syndromic HI. With HI associated with high genetic fitness, this indicates that Ghana will likely sustain an increase in the number of individuals living with inheritable HI. There is a universal newborn hearing screening (UNHS) program in Ghana. However, this program does not include genetic testing. Adding genetic...
Source: Public Health Genomics - December 10, 2020 Category: Genetics & Stem Cells Source Type: research
