Title Page / Table of Contents
Public Health Genomics 2016;19:I-1II (Source: Public Health Genomics)
Source: Public Health Genomics - September 20, 2016 Category: Genetics & Stem Cells Source Type: research
2016 Golden Helix Summer School - Cancer Genomics and Individualized Therapy. 22-26 September 2016, Syros Island, Greece: Abstracts
Public Health Genomics 2016;19:1-11 (Source: Public Health Genomics)
Source: Public Health Genomics - September 20, 2016 Category: Genetics & Stem Cells Source Type: research
Prevalence of Sickle Cell Trait and Reliability of Self-Reported Status among Expectant Parents in Nigeria: Implications for Targeted Newborn Screening
Background/Aims: Sickle cell disease (SCD) is a life-threatening, autosomal recessive blood disorder prevalent in sub-Saharan Africa. We identified the prevalence of sickle cell trait (SCT) among pregnant women and their male partners in Enugu State, Nigeria, and determined the accuracy of self-reported sickle cell status and its reliability for identifying high-risk newborns for targeted screening.Methods: We conducted a nested cohort study of expectant parents enrolled in the Healthy Beginning Initiative (HBI). The HBI is a cluster-randomized trial of a congregation-based approach designed to increase HIV testing. Partic...
Source: Public Health Genomics - September 9, 2016 Category: Genetics & Stem Cells Source Type: research
Let the Individuals Directly Concerned Decide: A Solution to Tragic Choices in Genetic Risk Information
Health-care systems as well as legislators and society seem largely unprepared to face and manage the massive production of genetic risk information. Ethics committees and professional bodies usually do not involve the individuals directly concerned in defining guidelines for genetic risk communication. Therefore, they do not always reflect people's needs and preferences. We argue in this article that we currently experience a cultural shift in medicine where individuals' concerns and preferences regarding genetic risk information are playing a more significant role than before, and that this should have some normative imp...
Source: Public Health Genomics - September 7, 2016 Category: Genetics & Stem Cells Source Type: research
Intellectual Disability in a Birth Cohort: Prevalence, Etiology, and Determinants at the Age of 4 Years
Conclusion: For about 40% of children, ID was attributed to nonbiological factors, suggesting that the rate may be reduced with appropriate interventions early in life.Public Health Genomics 2016;19:290-297 (Source: Public Health Genomics)
Source: Public Health Genomics - September 5, 2016 Category: Genetics & Stem Cells Source Type: research
Knowledge of Genetics and Attitudes toward Genetic Testing among College Students in Saudi Arabia
Conclusion: The knowledge of genetics among college students was higher than has been reported in other studies, and the attitudes toward genetic testing were fairly positive. Genetics educational programs that target youths may improve knowledge of genetics and create a public perception that further supports genetic testing.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - August 19, 2016 Category: Genetics & Stem Cells Source Type: research
Factors Associated with the Use of Gene Expression Profiles in Estrogen Receptor-Positive Early-Stage Breast Cancer Patients: A Nationwide Study
Conclusion: GEP use increased over time and was influenced by patient- and tumor-associated factors as well as by SES.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - August 10, 2016 Category: Genetics & Stem Cells Source Type: research
Is It Desirable that I Must Disclose My Genetic Data to Swiss Private Medical Insurances
Genetic testing has far-reaching consequences, not only in terms of immediate patient management and the wider implications for the patient and their families, but also with respect to disclosure to insurance companies. The focus of this review is the controversial but important topic of the use of genetic data in private medical insurance. We discuss the current legal regulation of genetic data in the context of Swiss insurance, what type(s) of information is relevant to insurance companies, and why ‘genetic exceptionalism' (the notion that genetic data has special status) persists. Furthermore, we discuss the sensitive...
Source: Public Health Genomics - August 4, 2016 Category: Genetics & Stem Cells Source Type: research
Is It Desirable that I Must Disclose My Genetic Data to Swiss Private Medical Insurances?
Genetic testing has far-reaching consequences, not only in terms of immediate patient management and the wider implications for the patient and their families, but also with respect to disclosure to insurance companies. The focus of this review is the controversial but important topic of the use of genetic data in private medical insurance. We discuss the current legal regulation of genetic data in the context of Swiss insurance, what type(s) of information is relevant to insurance companies, and why ‘genetic exceptionalism' (the notion that genetic data has special status) persists. Furthermore, we discuss the sensitive...
Source: Public Health Genomics - August 3, 2016 Category: Genetics & Stem Cells Source Type: research
Media Exposure and Genetic Literacy Skills to Evaluate Angelina Jolie's Decision for Prophylactic Mastectomy
Conclusion: These findings suggest that having higher genetic literacy skills may increase the public's ability to form opinions about clinical applications of genomic discovery. However, repeated media exposure to high-profile stories may artificially inflate confidence among those with low genetic literacy.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - July 18, 2016 Category: Genetics & Stem Cells Source Type: research
Clinician-Reported Barriers to Implementing Breast Cancer Chemoprevention in the UK: A Qualitative Investigation
Conclusions: Barriers to implementing preventive therapy within routine clinical practice are common and could be addressed by engaging all stakeholders during the development of policy documents.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - July 11, 2016 Category: Genetics & Stem Cells Source Type: research
The Sangre Por Salud Biobank: Facilitating Genetic Research in an Underrepresented Latino Community
Conclusion: Collaborative efforts such as the SPS Biobank are critical for ensuring that underrepresented minority populations are included in precision medicine initiatives and biomedical research that seeks to improve human health and reduce the burdens of disease.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - July 4, 2016 Category: Genetics & Stem Cells Source Type: research
Consent Issues in Genetic Research: Views of Research Participants
Conclusion: Understanding research participants' preferences, including their views on the need for re-consent, are critical to the success of the PMI.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - July 4, 2016 Category: Genetics & Stem Cells Source Type: research
Shooting for the Moon or Flying Too Near the Sun? Crossing the Value Rubicon in Precision Cancer Care
In his last two State of the Union addresses, President Barack Obama has focused on the need to deliver innovative solutions to improve human health, through the Precision Medicine Initiative in 2015 and the recently announced Cancer Moonshot in 2016. Precision cancer care has delivered clear patient benefit, but even for high-impact medicines such as imatinib mesylate (Glivec) in chronic myeloid leukaemia, the excitement at the success of this practice-changing clinical intervention has been somewhat tempered by the escalating price of this ‘poster child' for precision cancer medicine (PCM). Recent studies on the costs ...
Source: Public Health Genomics - June 21, 2016 Category: Genetics & Stem Cells Source Type: research
Clinical Trial Data as Public Goods: Fair Trade and the Virtual Knowledge Bank as a Solution to the Free Rider Problem - A Framework for the Promotion of Innovation by Facilitation of Clinical Trial Data Sharing among Biopharmaceutical Companies in the Era of Omics and Big Data
Conclusion: The Virtual Knowledge Bank is a sustainable and self-expanding model for secure and fair clinical trial data sharing that allows for sharing of clinical trial data, while at the same time it increases the innovation capacity of the biopharmaceutical industry.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - May 31, 2016 Category: Genetics & Stem Cells Source Type: research
