Temporal Patterns in the Evolutionary Genetic Distance of SARS-CoV-2 during the COVID-19 Pandemic
This study presents distinct patterns of the SARS-CoV-2 mutations across multiple proteins from the aspect of genetic distance. Future investigation shall be conducted to study the effects of accumulative mutations on epidemics characteristics.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - January 5, 2022 Category: Genetics & Stem Cells Source Type: research
Unlocking Access to Broad Molecular Profiling: Benefits, Barriers, and Policy Solutions
Conclusion: Policy proposals that aim to improve equitable patient access to CGP will need to consider new funding models, health technology assessment processes that capture both patient and systemic benefits, and appropriate regulatory standards to determine the quality of genomic profiling tests.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - December 27, 2021 Category: Genetics & Stem Cells Source Type: research
Comparison of a Cancer Family History Collection and Risk Assessment Tool – ItRunsInMyFamily – with Risk Assessment by Health-Care Professionals
Conclusion: The risk assessment provided by ItRuns was highly concordant with that of GC ’s, particularly for at-risk individuals. The use of such technology-based tools improves efficiency and can lead to greater numbers of at-risk individuals accessing genetic counseling, testing, and mutation-based interventions to improve health.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - December 6, 2021 Category: Genetics & Stem Cells Source Type: research
“We-Diseases” and Dyadic Decision-Making Processes: A Critical Perspective
Conclusions of the present critical review suggest to develop a new line of research on dyadic decision-making in the oncological domain, testing the Dyadic Model presented in the study and considering the interdependence of the data with appropriate levels of analysis.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - November 23, 2021 Category: Genetics & Stem Cells Source Type: research
Association between Genetic Polymorphisms of < b > < i > MIR3142HG < /i > < /b > and the Risk of Steroid-Induced Osteonecrosis of the Femoral Head in the Population of Northern China
Conclusion: Our results first confirm that the genetic polymorphism ofMIR3142HG is associated with steroid-induced ONFH susceptibility in Chinese Han population.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - November 17, 2021 Category: Genetics & Stem Cells Source Type: research
Acknowledgement to Reviewers
Public Health Genomics 2021;24:315 (Source: Public Health Genomics)
Source: Public Health Genomics - November 1, 2021 Category: Genetics & Stem Cells Source Type: research
Genetic and Nongenetic Determinants of Variable Warfarin Dose Requirements: A Report from North India
Conclusion: The model explains nearly half of the interindividual variation in warfarin dose in patients with atrial fibrillation and or requiring valve replacement.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - October 21, 2021 Category: Genetics & Stem Cells Source Type: research
Identification of Candidate Genes in Early-Stage Invasive Ductal Carcinoma Patients with High-Risk Mortality Using Genes Commonly Involved in Breast Cancer: A Retrospective Study
Conclusions: This study proposed an integrative approach for the identification of candidate genes for risk assessment of overall survival in these patients through typical survival analysis methods. The 14 candidate genes selected are particularly involved in cell-cycle processes, deoxyribonucleic acid repair, and drug resistance; their mutations were found to be generally associated with disease progression or therapeutic resistance, which is commonly associated with poor overall survival outcomes in IDC.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - October 11, 2021 Category: Genetics & Stem Cells Source Type: research
Altruism as an Explanation for Human Consanguinity
Background: Human inbreeding is a sociobiological puzzle. Despite widespread knowledge of its potential for genetic disorders, human consanguinity remains surprisingly common. The current reasons explaining its continued persistence in today ’s modern world have major shortcomings.Summary: We propose that the Neolithic Agrarian revolution modified the structure of populations. It increased competition for the limited resources in which a larger group had better chances of survival. As a result, small, drifting, socially open bands of hunter-gatherers were transformed into bigger, less mobile, and more powerful kinship gr...
Source: Public Health Genomics - September 23, 2021 Category: Genetics & Stem Cells Source Type: research
People with Cerebral Palsy and Their Family ’s Preferences about Genomics Research
Discussion: The success of genomic research and international data sharing efforts in CP are contingent upon broad support and recruitment. Ongoing consultation and engagement of individuals with CP and their families will facilitate trust and promote increased awareness of genomics in CP that may in turn maximize participant uptake and recruitment.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - September 17, 2021 Category: Genetics & Stem Cells Source Type: research
Psychological Distress and Quality of Life in Participants Undergoing Genetic Testing for Arrhythmogenic Right Ventricular Cardiomyopathy Caused by < b > < i > TMEM43 < /i > < /b > p.S358L: Is It Time to Offer Population-Based Genetic Screening?
Conclusion: Despite some initial anxiety, we show support for PBGS among research subjects who screened negative for theTMEM43 p.S358L variant in NL. These findings have implications for future PBGS programs in the province.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - September 9, 2021 Category: Genetics & Stem Cells Source Type: research
Evaluating Primary Care Providers ’ Readiness for Delivering Genetic and Genomic Services to Underserved Populations
Conclusion: Despite knowledge gaps, respondents recognized the value and need to bring these services to their patients, though would like more education on applying genetics and genomics into their practice, and more training about discussing risk factors associated with race or ethnicity. We provide further evidence of the need for educational resources and standardized guidelines for providers caring for underserved populations to optimize appropriate use and referral of genetic and genomic services and to reduce disparities in care.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - September 7, 2021 Category: Genetics & Stem Cells Source Type: research
Mapping Users ’ Experience of a Family History and Genetic Risk Algorithm Tool in Primary Care
Conclusion: User experience was shown to be a synthesis of obstacles, overcoming them with suggestions for improvements, and exploration of various coping mechanisms that may emerge from dealing with the stressor of “being at risk.”Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - August 31, 2021 Category: Genetics & Stem Cells Source Type: research
“Integrating China in the International Consortium for Personalized Medicine”: The Coordination and Support Action to Foster Collaboration in Personalized Medicine Development between Europe and China
“Integrating China in the International Consortium for Personalized Medicine” (IC2PerMed) is a coordination and support action funded within the Horizon 2020 work program. Following the guidance of the International Consortium for Personalized Medicine (ICPerMed), the project’s overarching aim is to align the European Union and China’s research agendas in the field of personalized medicine (PM) to enable a swift development of PM approaches in the EU with strong leverage upon EU-Chinese collaboration. Living in the COVID-19 era, we are witnessing how the challenges imposed by the pan demic all around the globe ha...
Source: Public Health Genomics - August 13, 2021 Category: Genetics & Stem Cells Source Type: research
Genetic Variation of Glutathione S-Transferase M1 Is Associated with Patients with Ovarian Endometriosis and Endometriosis-Related Primary Infertility
Conclusion: Our results suggest that theGSTM1 polymorphism is not only related to the genetic susceptibility to ovarian endometriosis but also a potential molecular marker of primary infertility in patients with ovarian endometriosis.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - August 12, 2021 Category: Genetics & Stem Cells Source Type: research
