Getting Personal: Accelerating Personalised and Precision Medicine Integration into Clinical Cancer Research and Care in Clinical Trials
Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - November 13, 2015 Category: Genetics & Stem Cells Source Type: research
Personalised and Precision Medicine in Cancer Clinical Trials: Panacea for Progress or Pandora's Box?
This article will address these competing issues, mainly from a European perspective, highlight the problems and challenges to healthcare systems and suggest potential solutions that will ensure that the cost/value rubicon is addressed in a way that allows stakeholders to work together to deliver optimal cost-effective cancer care, the benefits of which can be transferred directly to our patients.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - November 10, 2015 Category: Genetics & Stem Cells Source Type: research
Genetic Testing Awareness and Attitudes among Latinos: Exploring Shared Perceptions and Gender-Based Differences
Conclusions: The results highlight beliefs and barriers that future interventions could target to help ensure that Latinos have adequate understanding of and access to genomic medicine advances.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - November 10, 2015 Category: Genetics & Stem Cells Source Type: research
The Challenges of Precision Oncology Drug Development and Implementation
The drivers of precision medicine are clear: for patients (and physicians) - more options, durable clinical benefit, reduced exposure to non-effective drugs and potential to leverage current scientific and technological advances; for the pharmaceutical industry - the potential to tackle core challenges in discovering and developing better and more efficacious medicines, to reduce rates of attrition in drug development and to reduce development costs; for healthcare systems and payers - improved efficiency through the provision of effective care and avoiding ineffective treatments. Oncology has been at the vanguard, the imp...
Source: Public Health Genomics - November 10, 2015 Category: Genetics & Stem Cells Source Type: research
Decision-Making Process Related to Participation in Phase I Clinical Trials: A Nonsystematic Review of the Existing Evidence
Due to the lack of other treatment options, patient candidates for participation in phase I clinical trials are considered the most vulnerable, and many ethical concerns have emerged regarding the informed consent process used in the experimental design of such trials. Starting with these considerations, this nonsystematic review is aimed at analyzing the decision-making processes underlying patients' decision about whether to participate (or not) in phase I trials in order to clarify the cognitive and emotional aspects most strongly implicated in this decision. Considering that there is no uniform decision calculus and th...
Source: Public Health Genomics - November 4, 2015 Category: Genetics & Stem Cells Source Type: research
Virtual Clinical Trials, an Essential Step in Increasing the Effectiveness of the Drug Development Process
Every patient is different - his/her genomes, environment, disease history and exposure to drugs. Tumours, in particular, are often heterogeneous in their genetic make-up and their response to drugs, both within and between samples. Classic clinical trials basically ignore this complexity or, as in stratified medicine, attempt to reduce it to an analysis of a small number of still enormously heterogeneous patient groups. Medicine, however, is not the only area in which we are faced with such complex ‘n = 1' (every individual case is different) situations. The weather we experience today, characterised by tens of terabyte...
Source: Public Health Genomics - November 4, 2015 Category: Genetics & Stem Cells Source Type: research
Collaborative Crowdsourcing for the Diagnosis of Rare Genetic Syndromes: The DYSCERNE Experience
The big-data revolution is creating a challenge for the provision of services in the health sector to keep pace with the expectations of the general population. Utilization of crowdsourcing can impact positively on the quality, cost and speed of healthcare by involving large sections of professionals and the public and creating novel science within an ethical framework. In 2007, the DYSCERNE project was funded by the European Commission Public Health Executive Agency (EU DG Sanco) aimed at setting up a network of expertise for rare dysmorphic disorders. As part of DYSCERNE, a Dysmorphology Diagnostic System was set up to e...
Source: Public Health Genomics - October 10, 2015 Category: Genetics & Stem Cells Source Type: research
Maternal Telomere Length and Risk of Down Syndrome: Epidemiological Impact of Smokeless Chewing Tobacco and Oral Contraceptive on Segregation of Chromosome 21
Conclusion: Environmental/habitual factors interact with molecular components of the oocyte, which ultimately increases the risk of chromosome 21 nondisjunction and subsequently of giving birth to a child with Down syndrome.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - October 7, 2015 Category: Genetics & Stem Cells Source Type: research
Breast Cancer Survivors' Knowledge of Hereditary Breast and Ovarian Cancer following Genetic Counseling: An Exploration of General and Survivor-Specific Knowledge Items
Conclusion: Knowledge increased following genetic counseling, but the highest total average score at any time was (Source: Public Health Genomics)
Source: Public Health Genomics - September 22, 2015 Category: Genetics & Stem Cells Source Type: research
Exploring the Potential Emotional and Behavioural Impact of Providing Personalised Genomic Risk Information to the Public: A Focus Group Study
Conclusion: Participants recognised the potential for both positive and negative emotional and behavioural impacts related to receiving information on the personalised genomic risk of melanoma.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - September 22, 2015 Category: Genetics & Stem Cells Source Type: research
Stability of Attitudes to the Ethical Issues Raised by the Return of Incidental Genomic Research Findings in Children: A Follow-Up Study
Conclusions: The opinions of parents regarding genomic research remain stable over time. Guidelines on the return of results should incorporate these findings.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - September 10, 2015 Category: Genetics & Stem Cells Source Type: research
Association between a Genetic Variant in the hsa-miR-146a Gene and Cancer Risk: An Updated Meta-Analysis
Conclusion: We conclude that rs2910164 may represent a valuable biomarker associated with the risk of developing specific types of cancer.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - September 4, 2015 Category: Genetics & Stem Cells Source Type: research
Available Tools to Facilitate Early Patient Access to Medicines in the EU and the USA: Analysis of Conditional Approvals and the Implications for Personalized Medicine
Scientific knowledge and our understanding of the human body and diseases have limited any possible treatment tailoring to each patient. The technological advances enabling the integration of various data sets (e.g. ‘-omics', microbiome, epigenetics and environmental exposure) have facilitated a greater understanding of the human body, the molecular basis of disease and all the factors influencing disease onset, progression and response to treatment, thereby ushering in the era of personalized medicine. We evaluate the regulatory approaches available to facilitate early patient access to efficacious and safe compounds in...
Source: Public Health Genomics - August 28, 2015 Category: Genetics & Stem Cells Source Type: research
Using a Historical Lens to Envision the Next Generation of Genomic Translation Research
Conclusion: We make a case for creating new scientific meta-narratives in which discovery and translation research agendas are envisioned as an interdependent enterprise.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - July 28, 2015 Category: Genetics & Stem Cells Source Type: research
European Reference Networks and Guideline Development and Use: Challenges and Opportunities
Conclusion: Member States are at a decisive point in establishing the details to ensure the transparent and effective functioning of ERNs. Producing explicit plans for the development and use of trustworthy guidelines should be an essential part of this effort.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - July 22, 2015 Category: Genetics & Stem Cells Source Type: research
