Parent and Public Interest in Whole-Genome Sequencing
Conclusions: While US adults have varying interest levels in WGS, parents appear to have similar interests in genome testing for themselves and their youngest children. As WGS technology becomes available in the clinic and private market, clinicians should be prepared to discuss WGS risks and benefits with their patients.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - March 6, 2015 Category: Genetics & Stem Cells Source Type: research
Ask Not What Personalized Medicine Can Do for You - Ask What You Can Do for Personalized Medicine
Conclusions: Educating citizens in PM, as proposed in the reports, is important but may not suffice for the adoption of new behaviors and practices by a majority of citizens. Approaches taking into consideration the heterogeneity of backgrounds, abilities, and resources among citizens are needed and include modifying reimbursement and pricing mechanisms, diversifying research, and developing low-cost PM programs.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - March 6, 2015 Category: Genetics & Stem Cells Source Type: research
Rare Disease Registries Classification and Characterization: A Data Mining Approach
Conclusions: These results represent a useful source of information to facilitate the harmonization and interconnection of RDRs in accordance with the different profiles identified. It could help sharing the information between RDRs with similar profiles and, whenever possible, interconnections between registries with different profiles.Public Health Genomics 2015;18:113-122 (Source: Public Health Genomics)
Source: Public Health Genomics - February 7, 2015 Category: Genetics & Stem Cells Source Type: research
Factors Affecting Recall of Different Types of Personal Genetic Information about Alzheimer's Disease Risk: The REVEAL Study
Conclusions: Recall of genotype-specific information is high, but recall of exact risk estimates is lower. Incorrect recall of numeric risk may lead to distortions in understanding risk. Further research is needed to determine how best to communicate different types of genetic risk information to patients, particularly to those with lower educational levels and lower numeracy. Health-care professionals should be aware that each type of genetic risk information may be differentially interpreted and retained by patients and that some patient subgroups may have more problems with recall than others.Public Health Genomics (Sou...
Source: Public Health Genomics - January 23, 2015 Category: Genetics & Stem Cells Source Type: research
A One-Page Summary Report of Genome Sequencing for the Healthy Adult
We describe the design and delivery of a clinical genome sequencing report, including a one-page summary suitable for interpretation by primary care physicians. To illustrate our preliminary experience with this report, we summarize the genomic findings from 10 healthy participants in a study of genome sequencing in primary care.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - January 20, 2015 Category: Genetics & Stem Cells Source Type: research
A New Approach to Assessing Affect and the Emotional Implications of Personal Genomic Testing for Common Disease Risk
Conclusions: While (Source: Public Health Genomics)
Source: Public Health Genomics - January 20, 2015 Category: Genetics & Stem Cells Source Type: research
Premarital Screening for Hemoglobinopathies: Experience of a Single Center in Kurdistan, Iraq
Conclusions: Financial support would have increased opting for PND by high-risk couples. Further reduction in affected birth rates could be achieved by including parallel antenatal screening programs to cover those married before the initiation of the premarital program and improving the public health education and counseling programs.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - January 20, 2015 Category: Genetics & Stem Cells Source Type: research
Author Index / Subject Index Vol. 17, No. 5-6, 2014
Public Health Genomics 2014;17:320 (Source: Public Health Genomics)
Source: Public Health Genomics - December 12, 2014 Category: Genetics & Stem Cells Source Type: research
Title Page / Table of Contents
Public Health Genomics 2014;17:241-244 (Source: Public Health Genomics)
Source: Public Health Genomics - December 12, 2014 Category: Genetics & Stem Cells Source Type: research
Contents Vol. 17, 2014
Public Health Genomics 2014;17:I-IV (Source: Public Health Genomics)
Source: Public Health Genomics - December 12, 2014 Category: Genetics & Stem Cells Source Type: research
DataSHIELD: An Ethically Robust Solution to Multiple-Site Individual-Level Data Analysis
Conclusion: DataSHIELD can provide an innovative and robust solution for addressing commonly encountered ethics-related data-sharing concerns.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - December 12, 2014 Category: Genetics & Stem Cells Source Type: research
Genome-Wide Association Studies in Africans and African Americans: Expanding the Framework of the Genomics of Human Traits and Disease
Genomic research is one of the tools for elucidating the pathogenesis of diseases of global health relevance and paving the research dimension to clinical and public health translation. Recent advances in genomic research and technologies have increased our understanding of human diseases, genes associated with these disorders, and the relevant mechanisms. Genome-wide association studies (GWAS) have proliferated since the first studies were published several years ago and have become an important tool in helping researchers comprehend human variation and the role genetic variants play in disease. However, the need to expan...
Source: Public Health Genomics - November 26, 2014 Category: Genetics & Stem Cells Source Type: research
Prevalence and Correlates of Receiving and Sharing High-Penetrance Cancer Genetic Test Results: Findings from the Health Information National Trends Survey
Conclusions: We identified several novel psychosocial correlates of sharing genetic information. Health professionals may use this information to identify patients less likely to share information with at-risk family members.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - November 25, 2014 Category: Genetics & Stem Cells Source Type: research
Transfusion-Dependent Thalassemia in Northern Sarawak: A Molecular Study to Identify Different Genotypes in the Multi-Ethnic Groups and the Importance of Genomic Sequencing in Unstudied Populations
Conclusion: The Filipino β-deletion was the most common gene defect observed. Homozygosity for the Filipino β-deletion appears to be unique to the Malays in Sarawak. Genomic sequencing is an essential tool to detect rare genetic variants in the study of new populations.Public Health Genomics (Source: Public Health Genomics)
Source: Public Health Genomics - November 18, 2014 Category: Genetics & Stem Cells Source Type: research
An Index of Barriers for the Implementation of Personalised Medicine and Pharmacogenomics in Europe
Conclusions: Challenges in the above-mentioned areas can and must be successfully tackled if we are to create a healthier Europe through PM. In order to create an environment in which PM can thrive for the patients' best outcomes, there is an urgent need for systematic actions to remove as many barriers as possible. (Source: Public Health Genomics)
Source: Public Health Genomics - November 15, 2014 Category: Genetics & Stem Cells Source Type: research
